Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness.

Engel C.; Schmutzler R.K.; Schuster H.; Senter L.; Seynaeve C.M.; Shah P.D.; Sharma P.; Shin V.Y.; Silvestri V.; Simard J.; Singer C.F.; Skytte A.-B.; Snape K.; Solano A.R.; Soucy P.; Southey M.C.; Spurdle A.B.; Steele L.; Steinemann D.; Stoppa-Lyonnet D.; Stradella A.; Sunde L.; Sutter C.; Tan Y.Y.; Teixeira M.R.; Teo S.H.; Thomassen M.; Tibiletti M.G.; Tischkowitz M.; Tognazzo S.; Toland A.E.; Tommasi S.; Torres D.; Toss A.; Trainer A.H.; Tung N.; Van Asperen C.J.; Van Der Baan F.H.; Van Der Kolk L.E.; Van Der Luijt R.B.; Van Hest L.P.; Varesco L.; Varon-Mateeva R.; Viel A.; Vierstrate J.; Villa R.; Von Wachenfeldt A.; Wagner P.; Wang-Gohrke S.; Wappenschmidt B.; Weitzel J.N.; Wieme G.; Yadav S.; Yannoukakos D.; Yoon S.-Y.; Zanzottera C.; Zorn K.K.; D'Amico A.V.; Freedman M.L.; Pomerantz M.M.; Chenevix-Trench G.; Antoniou A.C.; Neuhausen S.L.; Ottini L.; Nielsen H.R.; Rebbeck T.R.; Patel V.L.; Busch E.L.; Friebel T.M.; Cronin A.; Leslie G.; McGuffog L.; Adlard J.; Agata S.; Agnarsson B.A.; Ahmed M.; Aittom K.; Alducci E.; Andrulis I.L.; Arason A.; Arnold N.; Artioli G.; Arver B.; Auber B.; Azzollini J.; Balmana J.; Barkardottir R.B.; Barnes D.R.; Barroso A.; Barrowdale D.; Belotti M.; Benitez J.; Bertelsen B.; Blok M.J.; Bodrogi I.; Bonadona V.; Bonanni B.; Bondavalli D.; Boonen S.E.; Borde J.; Borg A.; Bradbury A.R.; Brady A.; Brewer C.; Brunet J.; Buecher B.; Buys S.S.; Cabezas-Camarero S.; Caldes T.; Caliebe A.; Caligo M.A.; Calvello M.; Campbell I.G.; Carnevali I.; Carrasco E.; Chan T.L.; Chu A.T.W.; Chung W.K.; Claes K.B.M.; Cook J.; Cortesi L.; Couch F.J.; Daly M.B.; Damante G.; Darder E.; Davidson R.; De La Hoya M.; Della Puppa L.; Dennis J.; Diez O.; Ding Y.C.; Ditsch N.; Domchek S.M.; Donaldson A.; Dworniczak B.; Easton D.F.; Eccles D.M.; Eeles R.A.; Ehrencrona H.; Ejlertsen B.; Evans D.G.; Faivre L.; Faust U.; Feliubadalo L.; Foretova L.; Fostira F.; Fountzilas G.; Frost D.; Garcia-Barberan V.; Garre P.; Gauthier-Villars M.; Geczi L.; Gehrig A.; Gerdes A.-M.; Gesta P.; Giannini G.; Glendon G.; Godwin A.K.; Goldgar D.E.; Greene M.H.; Gutierrez-Barrera A.M.; Hahnen E.; Hamann U.; Hauke J.; Herold N.; Hogervorst F.B.L.; Honisch E.; Hopper J.L.; Hulick P.J.; Izatt L.; Jager A.; James P.; Janavicius R.; Jensen U.B.; Jensen T.D.; Johannsson O.Th.; John E.M.; Joseph V.; Kang E.; Kast K.; Kiiski J.I.; Kim S.-W.; Kim Z.; Ko K.-P.; Konstantopoulou I.; Kramer G.; Krogh L.; Kruse T.A.; Kwong A.; Larsen M.; Lasset C.; Lautrup C.; Lazaro C.; Lee J.; Lee J.W.; Lee M.H.; Lemke J.; Lesueur F.; Liljegren A.; Lindblom A.; Llovet P.; Lopez-Fernandez A.; Lopez-Perolio I.; Lorca V.; Loud J.T.; Ma E.S.K.; Mai P.L.; Manoukian S.; Mari V.; Martin L.; Matricardi L.; Mebirouk N.; Medici V.; Meijers-Heijboer H.E.J.; Meindl A.; Mensenkamp A.R.; Miller C.; Gomes D.M.; Montagna M.; Mooij T.M.; Moserle L.; Mouret-Fourme E.; Mulligan A.M.; Nathanson K.L.; Navratilova M.; Nevanlinna H.; Niederacher D.; Cilius Nielsen F.C.; Nikitina-Zake L.; Offit K.; Olah E.; Olopade O.I.; Ong K.-R.; Osorio A.; Ott C.-E.; Palli D.; Park S.K.; Parsons M.T.; Pedersen I.S.; Peissel B.; Peixoto A.; Perez-Segura P.; Peterlongo P.; Petersen A.H.; Porteous M.E.; Pujana M.A.; Radice P.; Ramser J.; Rantala J.; Rashid M.U.; Rhiem K.; Rizzolo P.; Robson M.E.; Rookus M.A.; Rossing C.M.; Ruddy K.J.; Santos C.; Saule C.; Scarpitta R.

Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/29381

Title:	Association of genomic domains in BRCA1 and BRCA2 with prostate cancer risk and aggressiveness.
Authors:	Engel C.;Schmutzler R.K.;Schuster H.;Senter L.;Seynaeve C.M.;Shah P.D.;Sharma P.;Shin V.Y.;Silvestri V.;Simard J.;Singer C.F.;Skytte A.-B.;Snape K.;Solano A.R.;Soucy P.;Southey M.C.;Spurdle A.B.;Steele L.;Steinemann D.;Stoppa-Lyonnet D.;Stradella A.;Sunde L.;Sutter C.;Tan Y.Y.;Teixeira M.R.;Teo S.H.;Thomassen M.;Tibiletti M.G.;Tischkowitz M.;Tognazzo S.;Toland A.E.;Tommasi S.;Torres D.;Toss A.;Trainer A.H.;Tung N.;Van Asperen C.J.;Van Der Baan F.H.;Van Der Kolk L.E.;Van Der Luijt R.B.;Van Hest L.P.;Varesco L.;Varon-Mateeva R.;Viel A.;Vierstrate J.;Villa R.;Von Wachenfeldt A.;Wagner P.;Wang-Gohrke S.;Wappenschmidt B.;Weitzel J.N.;Wieme G.;Yadav S.;Yannoukakos D.;Yoon S.-Y.;Zanzottera C.;Zorn K.K.;D'Amico A.V.;Freedman M.L.;Pomerantz M.M.;Chenevix-Trench G.;Antoniou A.C.;Neuhausen S.L.;Ottini L.;Nielsen H.R.;Rebbeck T.R.;Patel V.L.;Busch E.L.;Friebel T.M.;Cronin A.;Leslie G.;McGuffog L.;Adlard J.;Agata S.;Agnarsson B.A.;Ahmed M.;Aittom K.;Alducci E.;Andrulis I.L.;Arason A.;Arnold N.;Artioli G.;Arver B.;Auber B.;Azzollini J.;Balmana J.;Barkardottir R.B.;Barnes D.R.;Barroso A.;Barrowdale D.;Belotti M.;Benitez J.;Bertelsen B.;Blok M.J.;Bodrogi I.;Bonadona V.;Bonanni B.;Bondavalli D.;Boonen S.E.;Borde J.;Borg A.;Bradbury A.R.;Brady A.;Brewer C.;Brunet J.;Buecher B.;Buys S.S.;Cabezas-Camarero S.;Caldes T.;Caliebe A.;Caligo M.A.;Calvello M.;Campbell I.G.;Carnevali I.;Carrasco E.;Chan T.L.;Chu A.T.W.;Chung W.K.;Claes K.B.M.;Cook J.;Cortesi L.;Couch F.J.;Daly M.B.;Damante G.;Darder E.;Davidson R.;De La Hoya M.;Della Puppa L.;Dennis J.;Diez O.;Ding Y.C.;Ditsch N.;Domchek S.M.;Donaldson A.;Dworniczak B.;Easton D.F.;Eccles D.M.;Eeles R.A.;Ehrencrona H.;Ejlertsen B.;Evans D.G.;Faivre L.;Faust U.;Feliubadalo L.;Foretova L.;Fostira F.;Fountzilas G.;Frost D.;Garcia-Barberan V.;Garre P.;Gauthier-Villars M.;Geczi L.;Gehrig A.;Gerdes A.-M.;Gesta P.;Giannini G.;Glendon G.;Godwin A.K.;Goldgar D.E.;Greene M.H.;Gutierrez-Barrera A.M.;Hahnen E.;Hamann U.;Hauke J.;Herold N.;Hogervorst F.B.L.;Honisch E.;Hopper J.L.;Hulick P.J.;Izatt L.;Jager A.;James P.;Janavicius R.;Jensen U.B.;Jensen T.D.;Johannsson O.Th.;John E.M.;Joseph V.;Kang E.;Kast K.;Kiiski J.I.;Kim S.-W.;Kim Z.;Ko K.-P.;Konstantopoulou I.;Kramer G.;Krogh L.;Kruse T.A.;Kwong A.;Larsen M.;Lasset C.;Lautrup C.;Lazaro C.;Lee J. ;Lee J.W.;Lee M.H.;Lemke J.;Lesueur F.;Liljegren A.;Lindblom A.;Llovet P.;Lopez-Fernandez A.;Lopez-Perolio I.;Lorca V.;Loud J.T.;Ma E.S.K.;Mai P.L.;Manoukian S.;Mari V.;Martin L.;Matricardi L.;Mebirouk N.;Medici V.;Meijers-Heijboer H.E.J.;Meindl A.;Mensenkamp A.R.;Miller C.;Gomes D.M.;Montagna M.;Mooij T.M.;Moserle L.;Mouret-Fourme E.;Mulligan A.M.;Nathanson K.L.;Navratilova M.;Nevanlinna H.;Niederacher D.;Cilius Nielsen F.C.;Nikitina-Zake L.;Offit K.;Olah E.;Olopade O.I.;Ong K.-R.;Osorio A.;Ott C.-E.;Palli D.;Park S.K.;Parsons M.T.;Pedersen I.S.;Peissel B.;Peixoto A.;Perez-Segura P.;Peterlongo P.;Petersen A.H.;Porteous M.E.;Pujana M.A.;Radice P.;Ramser J.;Rantala J.;Rashid M.U.;Rhiem K.;Rizzolo P.;Robson M.E.;Rookus M.A.;Rossing C.M.;Ruddy K.J.;Santos C.;Saule C.;Scarpitta R.
Monash Health Department(s):	Monash University - School of Clinical Sciences at Monash Health
Institution:	(Patel, D'Amico) Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, MA, United States (Busch, Friebel, Rebbeck) Harvard T.H. Chan School of Public Health, Boston, MA, United States (Busch) Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States (Friebel, Cronin, Freedman, Pomerantz, Rebbeck) Dana-Farber Cancer Institute, Boston, MA, United States (Leslie, McGuffog, Barnes, Barrowdale, Dennis, Easton, Frost, Antoniou) Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (Adlard) Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom (Agata, Alducci, Matricardi, Montagna, Moserle, Tognazzo) Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy (Agnarsson, Arason, Barkardottir) Department of Pathology, Landspitali University Hospital, Reykjavik 101, Iceland (Agnarsson) School of Medicine, University of Iceland, Reykjavik, Iceland (Ahmed) North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom (Aittom) Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (Andrulis, Glendon) Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada (Andrulis) Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada (Arason, Barkardottir) BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, Iceland (Arnold) Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany (Artioli) ULSS 3 Serenissima, U.O.C. Oncologia ed Ematologia Oncologica, Mirano, Venice, Italy (Arver, Liljegren, Von Wachenfeldt) Department of Oncology, Karolinska Institutet, Stockholm, Sweden (Auber) Institute of Human Genetics, Hannover Medical School, Hannover, Germany (Azzollini, Manoukian, Peissel, Villa, Zanzottera) Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori di Milano, Milan, Italy (Balmana, Carrasco, Lopez-Fernandez) High Risk and Cancer Prevention Group, Vall d'Hebron Institute of Oncology, University Hospital Vall d'Hebron, Barcelona, Spain (Barroso) Human Genetics Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain (Belotti, Buecher, Gauthier-Villars, Lesueur, Mebirouk, Mouret-Fourme, Saule, Stoppa-Lyonnet) Service de Gen etique, Institut Curie, Paris, France (Benitez, Osorio) Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain (Benitez, Osorio) Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain (Bertelsen, Cilius Nielsen, Rossing) Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (Blok) Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, Netherlands (Bodrogi, Geczi) Department of Chemotherapy, National Institute of Oncology, Budapest, Hungary (Bonadona, Lasset) Unite de Prevention et d'Epidemiologie Gen etique, Centre Leon Berard, Lyon, France (Bonanni, Bondavalli, Calvello) Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS, Milan, Italy (Boonen) Clinical Genetic Unit, Department of Paediatrics, Zealand University Hospital, Roskilde, Denmark (Borde, Hauke, Herold, Larsen, Rhiem) Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany (Borde, Hahnen, Hauke, Herold, Larsen, Rhiem, Schmutzler, Wappenschmidt) Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany (Borde, Hahnen, Hauke, Herold, Larsen, Rhiem, Schmutzler, Wappenschmidt) Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany (Borg) Department of Oncology, Lund University, Ska ne University Hospital, Lund, Sweden (Bradbury, Domchek, Nathanson, Shah) Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States (Brady) North West Thames Regional Genetics Service, Kennedy Galton Centre, North West London Hospitals NHS Trust, Middlesex, United Kingdom (Brewer) Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, United Kingdom (Brunet, Darder) Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigacio Biomedica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain (Buys) Department of Medicine, Huntsman Cancer Institute, Salt Lake City, UT, United States (Cabezas-Camarero, Perez-Segura) Department of Oncology, Hospital Clinico San Carlos, IdISSC, Madrid, Spain (Caldes, De La Hoya, Garcia-Barberan, Garre, Llovet, Lopez-Perolio, Lorca) Medical Oncology Department, Hospital Cl nico San Carlos, Instituto de Investigacion Sanitaria San Carlos (IdISSC), Centro Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain (Caliebe) Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany (Caligo) Section of Molecular Genetics, Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy (Campbell) Peter MacCallum Cancer Center, Melbourne, VIC, Australia (Campbell, James) Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia (Carnevali, Tibiletti) UO Anatomia Patologica, Ospedale di Circolo-Universita dell'Insubria, Varese, Italy (Chan, Chu, Kwong, Ma) Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Centre, Happy Valley, Hong Kong (Chan, Ma) Department of Pathology, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong (Chung) Departments of Pediatrics and Medicine, Columbia University, New York, NY, United States (Claes, Vierstrate, Wieme) Centre for Medical Genetics, Ghent University, Ghent, Belgium (Cook) Shef-field Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom (Cortesi, Medici, Toss) Department of Oncology and Haematology, University of Modena and Reggio Emilia, Modena, Italy (Couch) Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States (Daly) Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, United States (Damante) Department of Medical and Biological Sciences, University of Udine, Udine, Italy (Davidson) Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom (Della Puppa, Viel) Division of Functional Onco-genomics and Genetics, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy (Diez) Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Barcelona, Spain (Ding, Steele, Neuhausen) Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States (Ditsch, Meindl) Department of Gynecology and Obstetrics, Ludwig Maximilian University of Munich, Munich, Germany (Donaldson) Clinical Genetics Department, St. Michael's Hospital, Bristol, United Kingdom (Dworniczak) Institute of Human Genetics, University of Munster, Munster, Germany (Easton) Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom (Eccles) Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom (Eeles) Oncogenetics Team, Institute of Cancer Research, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom (Ehrencrona) Department of Clinical Genetics, Lund University Hospital, Lund, Sweden (Ejlertsen) Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark (Engel) Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany (Engel) LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany (Evans) Divi-sion of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom (Evans) Manchester Centre for Genomic Medicine, St. Mary's Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (Faivre) Unite d'Oncogen Etique, Centre de Lutte Contre le Cancer, Centre Georges-Francois Leclerc, Dijon, France (Faust) Institute of Medical Genetics and Applied Genomics, University of Tubingen, Tubingen, Germany (Feliubadalo, Lazaro) Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain (Foretova, Navratilova) Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czechia (Fostira, Konstantopoulou, Yannoukakos) Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece (Fountzilas) Second Department of Medical Oncology, EUROMEDICA, General Clinic of Thessaloniki, Aristotle University of Thessaloniki, School of Medicine, Thessaloniki, Greece (Gehrig) Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University of Wurzburg, Wurzburg, Germany (Gerdes) Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark (Gesta) Service Regional Oncogenetique Poitou-Charentes, CH Niort, Niort, France (Giannini, Rizzolo, Silvestri, Ottini) Department of Molecular Medicine, University La Sapienza, Rome, Italy (Godwin) Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS, United States (Goldgar) Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United States (Greene, Loud) Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States (Gutierrez-Barrera) Department of Breast Medical Oncology, Clinical Genetics Program, University of Texas MD Anderson Cancer Center, Houston, TX, United States (Hamann, Rashid, Torres) Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany (Hogervorst) Family Cancer Clinic, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands (Honisch) Department of Gynecology and Obstetrics, University Hospital Dusseldorf, Heinrich-Heine University Dusseldorf, Dusseldorf, Germany (Hopper, Niederacher) Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia (Hulick) Center for Medical Genetics, NorthShore University Health-System, Evanston, IL, United States (Hulick) University of Chicago Pritzker School of Medicine, Chicago, IL, United States (Izatt) Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Coordinating Center, Netherlands Cancer Institute, Amsterdam, Netherlands (Izatt) Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom (Jager, Seynaeve) Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, Netherlands (James, Trainer) Parkville Familial Cancer Centre, Peter MacCallum Cancer Center, Melbourne, VIC, Australia (Janavicius) Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania (Jensen, Sunde) Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark (Jensen, Petersen, Skytte) Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark (Johannsson) Department of Oncology, Landspitali University Hospital, Reykjavik, Iceland (John) Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, United States (Joseph) Clinical Genetics Research Lab., Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, United States (Kang, Offit) Department of Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea (Kast) Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany (Kiiski, Nevanlinna) Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (Kim) Department of Surgery, Daerim Saint Mary's Hospital, Seoul, South Korea (Kim) Department of Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea (Ko) Department of Preventive Medicine, Gacheon University College of Medicine, Incheon, South Korea (Kramer) Department of Urology, Medical University of Vienna, Vienna, Austria (Krogh, Kruse, Thomassen, Nielsen) Department of Clinical Genetics, Odense University Hospital, Odense, Denmark (Kwong, Shin) Department of Surgery, University of Hong Kong, Pok Fu Lam, Hong Kong (Kwong) Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong (Lautrup) Department of Clinical Genetics, Aalborg University Hospital, Aalborg, Denmark (Lee, Lee) Department of Surgery, Soonchunhyang University, College of Medicine, Soonchunhyang University Hospital, Seoul, South Korea (Lee) Department of Surgery, Ulsan University College of Medicine, Asan Medical Center, Seoul, South Korea (Lemke) Institute of Human Genetics, University Hospital Leipzig, Leipzig, Germany (Lesueur, Mebirouk) Genetic Epidemiology of Cancer Team, Inserm U900, Paris, France (Lesueur, Mebirouk) Institut Curie, Paris, France (Lesueur, Mebirouk) Mines ParisTech, Fontainebleau, France (Lindblom) Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden (Lindblom) Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden (Mai) Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States (Mari) Departement d'Hematologie-Oncologie Medicale, Centre Antoine Lacassagne, Nice, France (Martin) Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom (Meijers-Heijboer) Department of Clinical Genetics, VU University Medical Center, Amsterdam, Netherlands (Mensenkamp) Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands (Miller) Department of Clinical Genetics, Alder Hey Hospital, Liverpool, United Kingdom (Gomes) Service de Biologie de la Reproduction, Cytogen Etique et Gen Etique Medicale, CHI Poissy - Saint Germain, Poissy, France (Mooij, Rookus, Van Der Baan) Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, Netherlands (Mulligan) Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada (Mulligan) Laboratory Medicine Program, University Health Network, Toronto, ON, Canada (Nikitina-Zake) Latvian Biomedical Research and Study Centre, Riga, Latvia (Offit, Robson) Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United States (Olah) Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary (Olopade) Center for Clinical Cancer Genetics, University of Chicago, Chicago, IL, United States (Ong) West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, United Kingdom (Ott) Institute for Medical Genetics and Human Genetics, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health, Berlin, Germany (Palli) Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy (Park) Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea (Park) Department of Biomedical Sciences, Seoul National University, Graduate School, Seoul, South Korea (Park) Cancer Research Institute, Seoul National University, Seoul, South Korea (Parsons, Spurdle, Chenevix-Trench) Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia (Pedersen) Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark (Peixoto, Santos, Teixeira) Department of Genetics, Portuguese Oncology Institute, Porto, Portugal (Peterlongo) Genome Diagnostics Program, IFOM - the FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy (Porteous) South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, United Kingdom (Pujana) Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain (Radice) Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy (Ramser) Division of Gynaecology and Obstetrics, Klinikum Rechts der Isar der Technischen Universitat Munchen, Munich, Germany (Rantala) Clinical Genetics, Karolinska Institutet, Stockholm, Sweden (Rashid) Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC), Lahore, Pakistan (Ruddy, Yadav) Department of Oncology, Mayo Clinic, Rochester, MN, United States (Scarpitta) Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy (Schuster) Unite d'Oncogen Etique, Centre de Lutte Contre le Cancer Paul Strauss, Strasbourg, France (Senter) Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH, United States (Sharma, Soucy) Department of Internal Medicine, Division of Oncology, University of Kansas Medical Center, Westwood, KS, United States (Simard) Genomics Center, Centre Hospitalier Universitaire de Quebec - Universite Laval, Research Centre, Quebec City, QC, Canada (Singer) Dept. of OB/GYN, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria (Snape) Medical Genetics Unit, St. George's, University of London, London, United Kingdom (Solano) INBIOMED, Faculty of Medicine, CONICET and CEMIC, Department of Clinical Chemistry, Medical Direction, University of Buenos Aires, Buenos Aires, Argentina (Southey) Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (Southey) Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia (Steinemann) Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany (Stoppa-Lyonnet) Department of Tumour Biology, INSERM U830, Paris, France (Stoppa-Lyonnet) Universite Paris Descartes, Paris, France (Stradella) Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, CIBERONC, Barcelona, Spain (Sutter) Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany (Tan) Department of OB/GYN, Medical University of Vienna, Vienna, Austria (Teixeira) Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal (Teo) Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia (Teo) Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia (Tischkowitz) Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, QC, Canada (Tischkowitz) Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom (Toland) Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH, United States (Tommasi) Istituto Nazionale Tumori 'Giovanni Paolo II, Bari, Italy (Torres) Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia (Tung) Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA, United States (Van Asperen) Department of Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands (Van Der Luijt) Department of Medical Genetics, University Medical Center, Utrecht, Netherlands (Van Hest) Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands (Varesco) Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy (Wagner) Department of Women's Health, Tubingen University Hospital, Tubingen, Germany (Wang-Gohrke) Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (Weitzel) Clinical Cancer Genetics, City of Hope, Duarte, CA, United States (Yoon) Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Selangor, Malaysia
Issue Date:	25-Feb-2020
Copyright year:	2020
Publisher:	American Association for Cancer Research Inc.
Place of publication:	United States
Publication information:	Cancer Research. 80 (3) (pp 624-638), 2020. Date of Publication: 01 Feb 2020.
Journal:	Cancer Research
Abstract:	Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 (BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 30 region of BRCA2 (c.7914) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001c.7913 [HR 1/4 1.78; 95% confidence interval (CI), 1.25-2.52; P 1/4 0.001], as well as elevated risk of Gleason 8 prostate cancer (HR 1/4 3.11; 95% CI, 1.63-5.95; P 1/4 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR 1/4 2.83; 95% CI, 1.71-4.68; P 1/4 0.00004) and elevated risk of Gleason 8 prostate cancer (HR 1/4 4.95; 95% CI, 2.12-11.54; P 1/4 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer.Copyright © 2020 American Association for Cancer Research.
DOI:	http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1158/0008-5472.CAN-19-1840
PubMed URL:	31723001 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31723001]
ISSN:	0008-5472
URI:	https://repository.monashhealth.org/monashhealthjspui/handle/1/29381
Type:	Article
Subjects:	gene structure BRCA2 protein/ec [Endogenous Compound] BRCA1 protein/ec [Endogenous Compound] tumor suppressor gene tumor invasion prostate cancer priority journal male human heterozygosity cancer diagnosis cancer grading cancer risk cohort analysis disease severity genetic association Gleason score germ line genetic risk article gene structure BRCA2 protein BRCA1 protein tumor suppressor gene tumor invasion prostate cancer heterozygosity cancer cancer grading cancer risk genetic association Gleason score germ line genetic risk human genetic association genetic risk germ line Gleason score heterozygosity tumor suppressor gene tumor invasion prostate cancer priority journal male Article cancer diagnosis cancer grading cancer risk cohort analysis disease severity gene structure
Type of Clinical Study or Trial:	Observational study (cohort, case-control, cross sectional or survey)
Appears in Collections:	Articles

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