Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/30328
Title: | ANZCCSG BabyBrain99; intensified systemic chemotherapy, second look surgery and involved field radiation in young children with central nervous system malignancy. | Authors: | Hassall T.E.;Cohn R.J.;Sullivan M.J.;Ashley D.M.;Downie P.A.;Wheeler G.C.;Kirby M.L.;Bandopadhayay P.;Rosenfeld J.V. | Institution: | (Bandopadhayay, Rosenfeld, Downie, Ashley) Children's Cancer Centre, Royal Children's Hospital and Monash Medical Centre, Melbourne, Australia (Hassall) Department of Oncology, Royal Children's Hospital, Brisbane, Australia (Wheeler) Peter McCallum Cancer Centre, Melbourne, Australia (Kirby) Women's and Children's Hospital, Adelaide, Australia (Cohn) Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Sydney, Australia (Sullivan) Children's Haematology and Oncology Centre, Canterbury District, New Zealand (Rosenfeld) Department of Surgery, Monash University, Melbourne, Australia (Ashley) Barwon Health Cancer Services, Geelong, Australia | Issue Date: | 6-Oct-2012 | Copyright year: | 2011 | Publisher: | Wiley-Liss Inc. (111 River Street, Hoboken NJ 07030-5774, United States) | Place of publication: | United States | Publication information: | Pediatric Blood and Cancer. 56 (7) (pp 1055-1061), 2011. Date of Publication: 1 July 2011. | Abstract: | Background: ANZCCSG BabyBrain99 is a trial of intensive systemic chemotherapy with dual stem cell supported treatment, second look surgery and involved field radiation for children less than four years of age with malignant central nervous system tumours. Procedure: Following primary resection, treatment included two courses of cisplatin and oral etoposide, a third course of mobilising chemotherapy (vincristine, etoposide, cyclophosphamide) with stem cell harvest, followed by intensive stem cell supported chemotherapy with high dose cyclophosphamide, etoposide and vincristine. Children were evaluated for second resection before proceeding to a second stem cell supported consolidation therapy consisting of melphalan and carboplatin. Patients then received involved field radiation therapy. Result(s): Thirty three children with a range of diagnoses were enrolled. Nine percent of children had metastatic disease at diagnosis. Eighteen children completed treatment including irradiation. At the end of induction the event free survival was 70% (54-86). Forty eight percent of children had a complete response, 18% had stable disease and 3% had a partial response. Five year overall survival was 40% (22-56) and event free survival was 33% (17-50). Children in whom a complete resection were achieved had a significantly superior outcome compared to those children without a complete resection, 5 year EFS 60% (45-75), as compared to 22% (13-30), P-value <0.05. Conclusion(s): BabyBrain99 confirms that intensive stem cell supported chemotherapy can be safely administered to infants with CNS tumours however overall prognosis remains poor. Importantly, the study reinforces a complete surgical resection as an important favourable prognostic indicator. © 2011 Wiley-Liss, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/pbc.22942 | PubMed URL: | 21298769 [http://www.ncbi.nlm.nih.gov/pubmed/?term=21298769] | ISSN: | 1545-5009 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/30328 | Type: | Article | Subjects: | hypokalemia/si [Side Effect] hypomagnesemia/si [Side Effect] hyponatremia/si [Side Effect] hypophosphatemia/si [Side Effect] infant leukopenia/si [Side Effect] male metastasis/co [Complication] multiple cycle treatment overall survival patient safety priority journal *radiation field *second look surgery stem cell transplantation systemic therapy thrombocytopenia/si [Side Effect] treatment outcome treatment response carboplatin/ae [Adverse Drug Reaction] carboplatin/cb [Drug Combination] carboplatin/dt [Drug Therapy] cisplatin/cb [Drug Combination] cisplatin/dt [Drug Therapy] cyclophosphamide/cb [Drug Combination] cyclophosphamide/do [Drug Dose] cyclophosphamide/dt [Drug Therapy] etoposide/cb [Drug Combination] etoposide/do [Drug Dose] etoposide/dt [Drug Therapy] etoposide/po [Oral Drug Administration] melphalan/ae [Adverse Drug Reaction] melphalan/cb [Drug Combination] melphalan/dt [Drug Therapy] vincristine/cb [Drug Combination] vincristine/do [Drug Dose] vincristine/dt [Drug Therapy] prognosis anemia/si [Side Effect] article bone marrow toxicity/si [Side Effect] *cancer chemotherapy cancer patient *central nervous system tumor/dt [Drug Therapy] *central nervous system tumor/rt [Radiotherapy] *central nervous system tumor/su [Surgery] central nervous system tumor/dt [Drug Therapy] child *childhood cancer/dt [Drug Therapy] *childhood cancer/rt [Radiotherapy] *childhood cancer/su [Surgery] childhood cancer/dt [Drug Therapy] clinical article drug megadose event free survival febrile neutropenia/si [Side Effect] female human hypocalcemia/si [Side Effect] female human hypocalcemia / side effect hypokalemia / side effect hypomagnesemia / side effect hyponatremia / side effect hypophosphatemia / side effect infant leukopenia / side effect male metastasis / complication multiple cycle treatment overall survival patient safety priority journal prognosis *radiation field *second look surgery stem cell transplantation systemic therapy thrombocytopenia / side effect treatment outcome treatment response cancer patient *cancer chemotherapy bone marrow toxicity / side effect article *central nervous system tumor / *drug therapy / *radiotherapy / *surgery anemia / side effect central nervous system tumor / drug therapy child *childhood cancer / *drug therapy / *radiotherapy / *surgery childhood cancer / drug therapy clinical article drug megadose event free survival febrile neutropenia / side effect |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.