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https://repository.monashhealth.org/monashhealthjspui/handle/1/30974| Title: | Macrophages and diabetic nephropathy. | Authors: | Tesch G.H. | Institution: | (Tesch) Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia | Issue Date: | 12-Oct-2012 | Copyright year: | 2010 | Publisher: | W.B. Saunders (Independence Square West, Philadelphia PA 19106-3399, United States) | Place of publication: | United States | Publication information: | Seminars in Nephrology. 30 (3) (pp 290-301), 2010. Date of Publication: May 2010. | Abstract: | Evidence from renal biopsies has shown that macrophage accumulation in diabetic kidneys predicts declining renal function, suggesting a pathogenic role for these cells in diabetic nephropathy. Further evidence from animal models has shown that macrophages are the major immune cells infiltrating the kidney in type 1 and type 2 diabetes, and that they contribute to the development of renal injury and sclerosis. This review examines macrophages in human and experimental diabetic nephropathy, exploring the mechanisms of macrophage recruitment and activation, and the process of macrophage-mediated injury in diabetic kidneys. The ability of current therapies and novel anti-inflammatory treatments to reduce macrophage-mediated injury in diabetic kidneys also is considered, which has important implications for the future management of patients with diabetic nephropathy. © 2010 Elsevier Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.semnephrol.2010.03.007 | PubMed URL: | 20620673 [http://www.ncbi.nlm.nih.gov/pubmed/?term=20620673] | ISSN: | 0270-9295 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/30974 | Type: | Article | Subjects: | kidney injury/et [Etiology] *macrophage macrophage activation macrophage function nephrosclerosis/et [Etiology] non insulin dependent diabetes mellitus nonhuman prediction priority journal angiotensin 2 receptor antagonist/dt [Drug Therapy] angiotensin 2 receptor antagonist/pd [Pharmacology] antihypertensive agent/cb [Drug Combination] antihypertensive agent/dt [Drug Therapy] antihypertensive agent/pd [Pharmacology] antioxidant/dt [Drug Therapy] antioxidant/pd [Pharmacology] cell adhesion molecule/ec [Endogenous Compound] cell nucleus receptor/ec [Endogenous Compound] chemokine/ec [Endogenous Compound] dipeptidyl carboxypeptidase inhibitor/dt [Drug Therapy] dipeptidyl carboxypeptidase inhibitor/pd [Pharmacology] eplerenone/dt [Drug Therapy] eplerenone/pd [Pharmacology] gliclazide/dt [Drug Therapy] gliclazide/pd [Pharmacology] hydroxymethylglutaryl coenzyme A reductase inhibitor/dt [Drug Therapy] hydroxymethylglutaryl coenzyme A reductase inhibitor/pd [Pharmacology] mitogen activated protein kinase p38 inhibitor/dt [Drug Therapy] mitogen activated protein kinase p38 inhibitor/pd [Pharmacology] mizoribine/dt [Drug Therapy] mizoribine/pd [Pharmacology] mycophenolic acid 2 morpholinoethyl ester/cb [Drug Combination] mycophenolic acid 2 morpholinoethyl ester/dt [Drug Therapy] mycophenolic acid 2 morpholinoethyl ester/pd [Pharmacology] peroxisome proliferator activated receptor gamma agonist/dt [Drug Therapy] peroxisome proliferator activated receptor gamma agonist/pd [Pharmacology] rapamycin/dt [Drug Therapy] rapamycin/pd [Pharmacology] spironolactone/dt [Drug Therapy] spironolactone/pd [Pharmacology] stress activated protein kinase inhibitor/pd [Pharmacology] unclassified drug monocyte chemotactic protein 1 inhibitor/dt [Drug Therapy] monocyte chemotactic protein 1 inhibitor/pd [Pharmacology] stress activated protein kinase inhibitor/dt [Drug Therapy] article cell infiltration cell proliferation diabetic nephropathy/dt [Drug Therapy] *diabetic nephropathy/dt [Drug Therapy] *diabetic nephropathy/et [Etiology] disease model evidence based medicine human immunocompetent cell insulin dependent diabetes mellitus kidney biopsy kidney failure kidney biopsy kidney failure kidney injury / etiology *macrophage macrophage activation macrophage function nephrosclerosis / etiology non insulin dependent diabetes mellitus cell infiltration prediction priority journal article nonhuman cell proliferation diabetic nephropathy / drug therapy *diabetic nephropathy / *drug therapy / *etiology disease model evidence based medicine human immunocompetent cell insulin dependent diabetes mellitus |
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