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https://repository.monashhealth.org/monashhealthjspui/handle/1/31335| Title: | Population-based surveillance for scedosporiosis in Australia: Epidemiology, disease manifestations and emergence of Scedosporium aurantiacum infection. | Authors: | McGregor A.;Cooley L.;Cox E.;Franklin C.;Korman T.;Morrissey O.;Spelman D.;Speed B.;Boan P.;Dyer J.;Gardam D.;McLennan D.;Murray R.;Pryce T.;Heath C.H.;Slavin M.A.;Sorrell T.C.;Handke R.;Harun A.;Phillips M.;Nguyen Q.;Delhaes L.;Ellis D.;Meyer W.;Chen S.C.A.;Collignon P.;Benn R.;Chambers I.;Dennis N.;DeWit D.;Ferguson J.;Gosbell I.;Gottlieb T.;Halliday C.;Holland J.;Kesson A.;Lawrence R.;Marriott D.;Newton P.;Palasanthrian P.;Pickles R.;Pritchard B.;Tierney L.;Tomasotos V.;Vaz R.;Weeks K.;Currie B.;Allworth A.;Coulter C.;Faoagali J.;Johnson B.;Looke D.;McCormack J.;Nimmo G.;O'Kane G.;Playford E.G.;Robson J.;Rowlands K.;Shaw D. | Institution: | (Heath) Department of Microbiology and Infectious Diseases, Royal Perth Hospital, University of Western Australia, Perth, WA, Australia (Slavin) Centre for Clinical Research Excellence in Infectious Diseases, Royal Melbourne Hospital, Melbourne, VIC, Australia (Sorrell, Chen) Centre for Infectious Diseases and Microbiology, Westmead Hospital, Darcy Road, Westmead, NSW 2145, Australia (Handke, Ellis) Mycology Unit, Women's and Children's Hospital, Adelaide, SA, Australia (Harun, Meyer, Chen) Molecular Mycology Research Laboratory, University of Sydney, Westmead Hospital, Sydney, NSW, Australia (Phillips) Western Australian Institute for Medical Research, Royal Perth Hospital, University of Western Australia, Perth, WA, Australia (Nguyen) Department of Microbiology and Infectious Diseases, St Vincent's Hospital, Sydney, NSW, Australia (Delhaes) Mycology Laboratory EA3609, Institute Pasteur, Lille, France (Collignon) The Canberra Hospital, Canberra, ACT, Australia (Benn) Royal Prince Alfred Hospital, Sydney, NSW, Australia (Chambers) Douglass Hanly Moir Pathology, Sydney, NSW, Australia (Dennis, Newton) Wollongong Hospital, Wollongong, NSW, Australia (DeWit) Gosford Hospital, Gosford, NSW, Australia (Ferguson, Tierney) John Hunter Hospital, New Lambton Heights, NSW, Australia (Gosbell, Tomasotos) Liverpol Hospital, Sydney, NSW, Australia (Gottlieb) Concord Hospital, Sydney, NSW, Australia (Halliday) Westmead Hospital, Westmead, NSW, Australia (Holland) Mayne Laverty Pathology, Sydney, NSW, Australia (Kesson) New Children's Hospital, Sydney, NSW, Australia (Lawrence) St George Hospital, Sydney, NSW, Australia (Marriott) St Vincent's Hospital, Sydney, NSW, Australia (Palasanthrian) Sydney Children's Hospital, Sydney, NSW, Australia (Pritchard, Weeks) Royal North Shore Hospital, St Leonards, NSW, Australia (Vaz) Orange Base Hospital, Orange, NSW, Australia (Currie) Royal Darwin Hospital, Darwin, NT, Australia (Allworth, Faoagali) Royal Brisbane Hospital, Brisbane, QLD, Australia (Coulter, O'Kane) The Prince Charles Hospital, Chermside, QLD, Australia (Johnson, Looke, Nimmo, Playford) Princess Alexandra Hospital, Woolloongabba, QLD, Australia (McCormack) The Mater Adult Hospital, Brisbane, QLD, Australia (Robson) Sullivan and Nicolaides Pathology, Brisbane, QLD, Australia (Rowlands, Shaw) Royal Adelaide Hospital, Adelaide, SA, Australia (Cooley, McGregor) Royal Hobart Hospital, Hobart, TAS, Australia (Cox) Launceston General Hospital, Launceston, TAS, Australia (Slavin, Franklin, Morrissey, Spelman) Alfred Hospital, Melbourne, VIC, Australia (Korman) Monash Medical Centre, Clayton, VIC, Australia (Speed) Austin Hospital, Melbourne, VIC, Australia (Boan, Gardam, Murray, Pryce) Royal Perth Hospital, Perth, WA, Australia (Dyer, McLennan) Fremantle Hospital, Fremantle, WA, Australia | Issue Date: | 14-Oct-2012 | Copyright year: | 2009 | Publisher: | Blackwell Publishing Ltd (9600 Garsington Road, Oxford OX4 2XG, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Clinical Microbiology and Infection. 15 (7) (pp 689-693), 2009. Date of Publication: 2009. | Abstract: | Australia-wide population-based surveillance for scedosporiosis identified 180 cases, with 118 (65.6%) cases of colonization and 62 (34.4%) cases of infection. Predisposing factors for isolation of Scedosporium spp. included chronic lung disease in 37.8% and malignancy in 21.7% of cases. Predictors of invasive disease (n = 62) included haematological stem cell transplantation (n = 7), leukaemia (n = 16) and diabetes mellitus (n = 8). Of 183 phenotypically-speciated isolates, 75 (41%) were Scedosporium prolificans (risk factors: haematologic cancer (n = 17), neutropaenia (n = 14)) and 108 (59%) had Scedosporium apiospermum/Pseudallescheria boydii phenotype [risk factor: diabetes (n = 15)]. Scedosporium prolificans (p 0.01) and leukaemia (p 0.03) independently predicted death. Epidemiological and antifungal susceptibility profiles of Scedosporium aurantiacum (prevalence >=15.8%) and S. apiospermum were similar. No patient with S aurantiacum infection (n = 6) died. This is the first description of clinical features associated with S. aurantiacum. © 2009 The Authors Journal compilation © 2009 European Society of Clinical Microbiology and Infectious Diseases. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1469-0691.2009.02802.x | PubMed URL: | 19549223 [http://www.ncbi.nlm.nih.gov/pubmed/?term=19549223] | ISSN: | 1198-743X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/31335 | Type: | Article |
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