Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/31593
Title: Stimulation of epithelial repair is a likely mechanism for the action of mifepristone in reducing duration of bleeding in users of progestogen-only contraceptives.
Authors: Kaitu'u-Lino T.J.;Morison N.B.;Salamonsen L.A.;Fraser I.S.
Institution: (Morison, Kaitu'u-Lino, Salamonsen) Prince Henry's Institute, Monash Medical Centre, 246 Clayton Rd., Clayton, VIC 3168, Australia (Kaitu'u-Lino) Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC 3168, Australia (Fraser) Sydney Centre for Reproductive Health Research, FPA Health, Ashfield, NSW 2131, Australia
Issue Date: 17-Oct-2012
Copyright year: 2008
Publisher: BioScientifica Ltd. (Euro House, 22 Apex Court, Woodlands, Bradley Stoke, Bristol BS32 4JT, United Kingdom)
Place of publication: United Kingdom
Publication information: Reproduction. 136 (2) (pp 267-274), 2008. Date of Publication: August 2008.
Abstract: Many women using progestogen (P)-only contraceptives experience uterine bleeding problems. In clinical trials, a single low dose of mifepristone, given to Implanon users at the beginning of a bleeding episode reduced the number of bleeding days by - 50% compared with controls. In this study, a single dose of mifepristone was administered to etonogestrel (ENG)-exposed pseudo-pregnant mice, 5 days after artificial decidualization was induced when the endometrium showed signs of bleeding. Control mice received vehicle alone. Mice were culled 12-, 18-, 24- and 48-h post-treatment. In the continued presence of ENG, a single dose of mifepristone stimulated tissue breakdown followed by very rapid repair: most treated tissues were fully restored to the pre-decidualized state by 48 h post-treatment. During repair, proliferating cells (Ki67 immunostained) were localized to a band of cells around the basal area in breaking down tissues and to the repairing luminal epithelium and glands. Progesterone receptor-positive cells were largely localized to the basal area of the breaking down tissue in treated mice compared with decidual cells in controls. Oestrogen receptor-positive cells were observed in the repairing luminal epithelium and glands compared with the decidua and the basal region in control tissues. It is concluded that mifepristone treatment stimulates rapid restoration of luminal epithelial integrity: such action may be a key event in reducing the number of bleeding days observed in women using Implanon who were treated with a single dose of mifepristone. © 2008 Society for Reproduction and Fertility.
DOI: http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1530/REP-08-0076
PubMed URL: 18499709 [http://www.ncbi.nlm.nih.gov/pubmed/?term=18499709]
ISSN: 1470-1626
URI: https://repository.monashhealth.org/monashhealthjspui/handle/1/31593
Type: Article
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