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https://repository.monashhealth.org/monashhealthjspui/handle/1/31818| Title: | Extramedullary relapse of multiple myeloma associated with a shift in secretion from intact immunoglobulin to light chains. | Authors: | Patil S.;Spencer A.;Dawson M.A. | Institution: | (Dawson, Spencer) Department of Haematology and Bone Marrow Transplantation, Alfred Hospital, Commercial Road, Melbourne, Vic. 3181, Australia (Patil, Spencer) Department of Clinical Haematology, Monash Hospital, Clayton Road, Melbourne, Vic. 3168, Australia (Dawson) The Alfred, Commercial Road, Melbourne, Vic. 3181, Australia | Issue Date: | 16-Oct-2012 | Copyright year: | 2007 | Publisher: | Ferrata Storti Foundation (Via G. Belli 4, Pavia 27100, Italy) | Place of publication: | Italy | Publication information: | Haematologica. 92 (1) (pp 143-144), 2007. Date of Publication: January 2007. | Abstract: | Biological therapies in multiple myeloma have heralded a new and exciting era for treatment to combat this disease. However the evolutionary pressures that these drugs place on the microenvironment has resulted in a change in the biological behaviour of this malignancy and novel manifestations of relapsed disease. This is illustrated in our series of three patients showing fulminant relapse of disease with plasmablastic features, an extramedullary predilection and a shift in secretion from intact immunoglobulin to free light chains only. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3324/haematol.10297 | PubMed URL: | 17229655 [http://www.ncbi.nlm.nih.gov/pubmed/?term=17229655] | ISSN: | 0390-6078 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/31818 | Type: | Article | Subjects: | male *multiple myeloma/dt [Drug Therapy] somnolence/si [Side Effect] treatment response Bence Jones protein/ec [Endogenous Compound] cisplatin/cb [Drug Combination] cisplatin/dt [Drug Therapy] clodronic acid/dt [Drug Therapy] cyclophosphamide/cb [Drug Combination] cyclophosphamide/dt [Drug Therapy] dexamethasone/cb [Drug Combination] dexamethasone/dt [Drug Therapy] doxorubicin/cb [Drug Combination] doxorubicin/dt [Drug Therapy] etoposide/cb [Drug Combination] etoposide/dt [Drug Therapy] idarubicin/cb [Drug Combination] idarubicin/dt [Drug Therapy] immunoglobulin heavy chain/ec [Endogenous Compound] immunoglobulin light chain/ec [Endogenous Compound] lenalidomide/dt [Drug Therapy] melphalan/cb [Drug Combination] melphalan/dt [Drug Therapy] pamidronic acid/dt [Drug Therapy] prednisolone/cb [Drug Combination] prednisolone/dt [Drug Therapy] thalidomide/ae [Adverse Drug Reaction] thalidomide/dt [Drug Therapy] vincristine/cb [Drug Combination] zoledronic acid/dt [Drug Therapy] vincristine/dt [Drug Therapy] adult aged article biological therapy cancer chemotherapy cancer relapse case report clinical feature constipation/si [Side Effect] disease activity disease course drug megadose female human low drug dose drug megadose female human low drug dose male *multiple myeloma / *drug therapy somnolence / side effect article aged adult treatment response biological therapy cancer chemotherapy cancer relapse case report clinical feature constipation / side effect disease activity disease course |
Type of Clinical Study or Trial: | Case series or case report |
| Appears in Collections: | Articles |
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