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https://repository.monashhealth.org/monashhealthjspui/handle/1/31857| Title: | Anti-CD20 antibody in thrombotic thrombocytopenic purpura refractory to plasma exchange. | Authors: | Chow K.V.;Hogan C.;Nicholls K.;Branley P.;Carroll R.;Becker G. | Institution: | (Chow, Carroll, Nicholls, Becker) Department of Nephrology, Royal Melbourne Hospital, Melbourne, Vic., Australia (Hogan) Department of Haematology, Royal Melbourne Hospital, Melbourne, Vic., Australia (Branley) Monash Medical Centre, Royal Melbourne Hospital, Melbourne, Vic., Australia (Nicholls, Becker, Hogan) University of Melbourne, Melbourne, Vic., Australia (Nicholls) Department of Nephrology, Royal Melbourne Hospital, Grattan Street, Parkville, Vic. 3050, Australia | Issue Date: | 16-Oct-2012 | Copyright year: | 2007 | Publisher: | Blackwell Publishing (550 Swanston Street, Carlton South VIC 3053, Australia) | Place of publication: | Australia | Publication information: | Internal Medicine Journal. 37 (5) (pp 329-332), 2007. Date of Publication: May 2007. | Abstract: | Thrombotic thrombocytopenic purpura is a rare condition characterized by microangiopathic haemolytic anaemia, thrombocytopenia, altered neurology, renal impairment and fever. While plasma exchange has reduced mortality from more than 90% to between 10 and 30%, a proportion of cases fail to respond. Rituximab may be efficacious in the management of refractory cases of thrombotic thrombocytopenic purpura. We present two cases in which rituximab was used with successful outcomes. Treatment resulted in resolution of severe clinical and haematological abnormalities in both patients. There has been no relapse after 16 months follow up. Our experience supports the use of rituximab in difficult cases of TTP. Ongoing evaluation of its use is in progress at our institution. © 2007 The Authors. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1445-5994.2007.01338.x | PubMed URL: | 17504282 [http://www.ncbi.nlm.nih.gov/pubmed/?term=17504282] | ISSN: | 1444-0903 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/31857 | Type: | Article | Subjects: | clinical feature drug efficacy epileptic state/co [Complication] epileptic state/dt [Drug Therapy] female human hypertension male *plasmapheresis refractory thrombocytopenia/dt [Drug Therapy] refractory thrombocytopenia/th [Therapy] single drug dose *thrombotic thrombocytopenic purpura/di [Diagnosis] *thrombotic thrombocytopenic purpura/dt [Drug Therapy] *thrombotic thrombocytopenic purpura/th [Therapy] treatment outcome anticonvulsive agent/dt [Drug Therapy] immunoglobulin/dt [Drug Therapy] immunoglobulin/iv [Intravenous Drug Administration] *rituximab/dt [Drug Therapy] vincristine/dt [Drug Therapy] priority journal adult article case report male *plasmapheresis priority journal refractory thrombocytopenia / drug therapy / therapy single drug dose *thrombotic thrombocytopenic purpura / *diagnosis / *drug therapy / *therapy treatment outcome clinical feature drug efficacy article adult case report epileptic state / complication / drug therapy female human hypertension |
Type of Clinical Study or Trial: | Case series or case report |
| Appears in Collections: | Articles |
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