Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/32278
Title: | Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours. | Authors: | Alexiadis M.;Jobling T. ;McNeilage J.;Fuller P.J. | Institution: | (Fuller, Alexiadis, Jobling, McNeilage) Prince Henry's Institute of Medical Research, Department of Gynaecology Oncology, Monash Medical Centre, Clayton, Vic. 3168, Australia (Fuller) Prince Henry's Institute of Medical Research, PO Box 5152, Clayton, Vic. 3168, Australia | Issue Date: | 17-Oct-2012 | Copyright year: | 2005 | Publisher: | Blackwell Publishing Ltd (9600 Garsington Road, Oxford OX4 2XG, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Clinical Endocrinology. 63 (1) (pp 111-115), 2005. Date of Publication: July 2005. | Abstract: | Objective: The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pituitary hormone stimulation and synthesize steroid hormones. Design(s): To test the hypothesis that seladin-1 may also have a role in the pathogenesis of GCT, we determined the expression of seladin-1 in a cohort of GCT and in mucinous and serous cystadenocarcinomas and in normal ovary. Measurements: Expression was determined by RT-PCR using gene specific primers and probes combined with Southern blot analysis of the PCR products. Result(s): Seladin-1 expression was identified in the normal ovary, mucinous cystadenocarcinomas and serous cystadenocarcinomas of the ovary whereas no expression was observed in the GCT. Conclusion(s): Based on our results, seladin-1 is not expressed in the granulosa cells or at least not in those that give rise to GCT. © 2005 Blackwell Publishing Ltd. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1365-2265.2005.02308.x | PubMed URL: | 15963070 [http://www.ncbi.nlm.nih.gov/pubmed/?term=15963070] | ISSN: | 0300-0664 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/32278 | Type: | Article | Subjects: | clinical article controlled study cystadenocarcinoma female gene control *gene expression gene function *granulosa cell tumor/et [Etiology] human human tissue mucinous carcinoma *ovary tumor/et [Etiology] pathogenesis priority journal *protein localization reverse transcription polymerase chain reaction Southern blotting steroidogenesis upregulation *gene product/ec [Endogenous Compound] unclassified drug *3beta hydroxysteroid delta24 reductase/ec [Endogenous Compound] *seladin 1/ec [Endogenous Compound] adrenal cortex tumor adult aged article human tissue mucinous carcinoma *ovary tumor / *etiology pathogenesis priority journal *protein localization reverse transcription polymerase chain reaction Southern blotting steroidogenesis gene function upregulation *gene expression gene control female cystadenocarcinoma controlled study clinical article article aged adult adrenal cortex tumor *granulosa cell tumor / *etiology human |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.