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Title: | Antiretroviral treatment change among HIV, hepatitis B virus and hepatitis C virus co-infected patients in the Australian HIV Observational Database. | Authors: | Wood H.;Watson K.;Anderson J.;Moore R.;Russell D.;McGovern G.;McNair R.;Lowe K.;Bal J.;Medland N.;Mallal S.;French M.;Skett J.;Moore C.;Petoumenos K.;Ringland C.;Goodman R.;Gotowski M.;Couldwell D.;Lewis L.;Austin D.;Block M.;Quan D.;Gowers A.;Brown K.;Skobalj N.;O'Connor C.;Mitchell M.;Templeton D.;Liang M.T.;Allen D.;Strazdinis B.;Mulhall B.;Mutimer K.;Armishaw J.;Cooper D.;Carr A.;Lacey M.;Pell C.;Rohrsheim R.;Finlayson R.;Richardson R.;Ellis D.;Baker D.;Kidd J.;McFarlane R.;Vale R.;Canavan P.;Law M.;Smith D.;Huffam S.;Savage J.;Morgan S.;Knibbs P.;Rogers G.;Markinson S.;Sullivan C.;Downey F.;Curry M.;Oddy J.;Thompson J.;Ree H.;Magon H.;Sowden D.;Walker A.;Orth D.;Lister G.;Youds D.;Chuah J.;James R.;Frankhauser W.;Dickson B.;Bradford D.;Leamy J.;D'Arcy Evans C.;Reid T.;Laing J.;Woolley I. ;Korman T. ;Padiglione A.;Visvanathan K.;Roth N.;Eu B.;Strecker S.;Mijch A.;Hoy J.;Pierce A.;McCormack C. | Monash Health Department(s): | Infectious Diseases and Clinical Microbiology | Institution: | (Petoumenos, Ringland) National Center in HIV Epidemiology and Clinical Research, The University of New South Wales, Victoria Street, Darlinghurst, NSW 2010, Australia (Goodman, Gotowski) Bligh Street Clinic, Tamworth, NSW, Australia (Couldwell, Lewis) Blue Mountains Sexual Health and HIV Clinic, Katoomba, NSW, Australia (Austin, Block, Quan, Gowers) Holdsworth House General Practice, Darlinghurst, NSW, Australia (Brown, Skobalj) Illawarra Sexual Health, Warrawong, NSW, Australia (O'Connor, Mitchell) Livingstone Road Sexual Health Centre, Marrickville, NSW, Australia (Templeton) Macquarie Sexual Health Center, Dubbo, NSW, Australia (Liang) Nepean Sexual Health and HIV Clinic, Penrith, NSW, Australia (Allen, Strazdinis, Mulhall) Holden Clinic, Gosford, NSW, Australia (Smith, Mutimer, Armishaw) Sexual Health and AIDS Services, Lismore, NSW, Australia (Cooper, Carr, Lacey) St Vincents Hospital, Sydney, NSW, Australia (Pell, Rohrsheim) Sydney Sexual Health Center, Sydney, NSW, Australia (Finlayson, Richardson) Taylor Square Private Clinic, Darlinghurst, NSW, Australia (Ellis) The Medical and Vein Centre, Coffs Harbour, NSW, Australia (Baker, Kidd, McFarlane, Vale) 407 Bourke Street, Surry Hill, NSW, Australia (Canavan, Law, Smith) National Center in HIV Epidemiology and Clinical Research, Darlinghurst, NSW 2010, Australia (Huffam, Savage, Morgan, Knibbs) Communicable Disease Centre, Royal Darwin Hospital, Darwin, North. Territ., Australia (Rogers, Markinson, Sullivan, Downey, Curry, Oddy, Thompson) The Care and Prevention Programme, Adelaide University, Adelaide, SA, Australia (Ree, Magon) AIDS Medical Unit, Brisbane, QLD, Australia (Sowden, Walker) Blackall Terrace Specialist Centre, Blackall Terrace, QLD, Australia (Orth, Lister, Youds) Gladstone Road Medical Centre, Highgate Hill, QLD, Australia (Chuah, James, Frankhauser, Dickson) Gold Coast Sexual Health Clinic, Miami, QLD, Australia (Bradford, Leamy, D'Arcy Evans) Sexual Health Program, Cairns Base Hospital, Cairns, QLD, Australia (Reid, Laing) Melbourne Sexual Health Centre, Carlton, Vic., Australia (Woolley, Korman, Padiglione, Visvanathan) Monash Medical Centre, Clayton, Vic., Australia (Roth, Eu, Strecker, Russell, Wood) Prahran Market Clinic, South Yarra, Vic., Australia (Mijch, Hoy, Pierce, McCormack, Watson) The Alfred Hospital, Prahran, Vic., Australia (Anderson, Moore, Russell, McGovern, McNair, Lowe, Bal) The Carlton Clinic, Carlton, Vic., Australia (Medland) The Centre Clinic, St Kilda, Vic., Australia (Medland) National Association of People with AIDS, East Brunswick, Vic., Australia (Mallal, French, Skett, Moore) Department of Clinical Immunology, Royal Perth Hospital, Perth, WA, Australia | Issue Date: | 17-Oct-2012 | Copyright year: | 2005 | Publisher: | Blackwell Publishing Ltd (9600 Garsington Road, Oxford OX4 2XG, United Kingdom) | Place of publication: | United Kingdom | Publication information: | HIV Medicine. 6 (3) (pp 155-163), 2005. Date of Publication: May 2005. | Abstract: | Objectives: To assess the impact of highly active antiretroviral therapy (HAART) on rates of change of antiretroviral treatment among patients co-infected with hepatitis B virus (HBV) and/or hepatitis C virus (HCV) in the Australian HIV Observational Database (AHOD). Method(s): Analysis was based on 805 of the 2218 patients recruited to the AHOD by March 2003, who had commenced HAART after 1 January 1997, who had recorded test results for HBV surface antigen and anti-HCV antibody, and who had follow-up of more than 3 months. The effect of hepatitis co-infection on the rate of antiretroviral treatment change after commencing HAART was assessed using a random-effect Poisson regression model. Result(s): Among those included in the analyses, the prevalences of HBV and HCV were 4.8% and 12.8%, respectively. The overall rate of combination antiretroviral treatment change was 0.74 combinations per year. Factors independently associated with an increased rate of change of combination antiretroviral treatment were: prior AIDS-defining illness; prior exposure to double combination antiretroviral therapy; and antiretroviral treatment class. Co-infection with HBV and/or HCV was not found to be significantly associated with the rate of combination antiretroviral treatment change. Conclusion(s): While both HBV and HCV co-infections are relatively common in the AHOD, they do not appear to be serious impediments to the treatment of HIV-infected patients. © 2005 British HIV Association. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/j.1468-1293.2005.00280.x | PubMed URL: | 15876281 [http://www.ncbi.nlm.nih.gov/pubmed/?term=15876281] | ISSN: | 1464-2662 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/32288 | Type: | Article | Subjects: | RNA directed DNA polymerase inhibitor/ae [Adverse Drug Reaction] acquired immune deficiency syndrome/co [Complication] acquired immune deficiency syndrome/dt [Drug Therapy] acquired immune deficiency syndrome/et [Etiology] adult article Australia clinical observation comorbidity controlled study data base drug exposure drug withdrawal female follow up *hepatitis B/et [Etiology] Hepatitis B virus *hepatitis C/et [Etiology] Hepatitis C virus highly active antiretroviral therapy human Human immunodeficiency virus *Human immunodeficiency virus infection/dt [Drug Therapy] *Human immunodeficiency virus infection/et [Etiology] liver disease/si [Side Effect] major clinical study male medical assessment medical record patient care prevalence priority journal regression analysis treatment outcome *antiretrovirus agent/ae [Adverse Drug Reaction] *antiretrovirus agent/cb [Drug Combination] *antiretrovirus agent/dt [Drug Therapy] efavirenz/ae [Adverse Drug Reaction] efavirenz/cb [Drug Combination] efavirenz/dt [Drug Therapy] hepatitis B surface antigen/ec [Endogenous Compound] hepatitis C antibody/ec [Endogenous Compound] nevirapine/ae [Adverse Drug Reaction] nevirapine/cb [Drug Combination] nevirapine/dt [Drug Therapy] proteinase inhibitor/ae [Adverse Drug Reaction] proteinase inhibitor/cb [Drug Combination] proteinase inhibitor/dt [Drug Therapy] RNA directed DNA polymerase inhibitor/cb [Drug Combination] RNA directed DNA polymerase inhibitor/dt [Drug Therapy] follow up *hepatitis B / *etiology Hepatitis B virus *hepatitis C / *etiology Hepatitis C virus highly active antiretroviral therapy human Human immunodeficiency virus *Human immunodeficiency virus infection / *drug therapy / *etiology liver disease / side effect major clinical study male medical assessment medical record patient care prevalence priority journal regression analysis article adult acquired immune deficiency syndrome / complication / drug therapy / etiology treatment outcome Australia clinical observation comorbidity controlled study data base drug exposure drug withdrawal female |
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