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Title: | Low blood selenium concentrations in schizophrenic patients on clozapine. | Authors: | Vaddadi G.;Vaddadi K.S.;Soosai E. | Institution: | (Vaddadi) Department of Psychological Medicine, Monash University, Monash Medical Centre, 246 Clayton Road, Clayton, Vic. 3168, Australia (Soosai) Clayton Comm. Mental Health Service, 270 Clayton Road, Clayton, Vic. 3168, Australia (Vaddadi) Austin/Repatriation Medical Centre, Studley Road, Heidelberg, Vic. 3084, Australia | Issue Date: | 17-Oct-2012 | Copyright year: | 2003 | Publisher: | Blackwell Publishing Ltd (9600 Garsington Road, Oxford OX4 2XG, United Kingdom) | Place of publication: | United Kingdom | Publication information: | British Journal of Clinical Pharmacology. 55 (3) (pp 307-309), 2003. Date of Publication: 01 Mar 2003. | Abstract: | Aims: To compare plasma and red-cell selenium concentrations of schizophrenic patients treated with clozapine, with healthy controls and patients with mood disorders. Method(s): Plasma and red-cell selenium concentrations were measured in random venous blood samples from four groups: mood disorder (n = 36), schizophrenics treated with clozapine (n = 54), schizophrenics not treated with clozapine (n = 41) and a healthy control group (n = 56). Assays were performed by an independent laboratory that was blinded to the patient groups and specializes in estimating trace metal concentrations. Result(s): Selenium concentrations in plasma and red cells were found to be significantly lower in schizophrenic patients treated with clozapine as compared with all other groups. Conclusion(s): Selenium is an essential antioxidant. Its deficiency has been implicated in myocarditis and cardiomyopathy. Low selenium concentrations in clozapine-treated patients may be important in the pathogenesis of life threatening cardiac side-effects associated with clozapine. Further clinical studies are being conducted to explore this important clinical observation and its therapeutic implications. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1046/j.1365-2125.2003.01773.x | PubMed URL: | 12630982 [http://www.ncbi.nlm.nih.gov/pubmed/?term=12630982] | ISSN: | 0306-5251 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/32693 | Type: | Article | Subjects: | *schizophrenia/dt [Drug Therapy] selenium deficiency/si [Side Effect] trace metal blood level *clozapine/ae [Adverse Drug Reaction] *clozapine/do [Drug Dose] *clozapine/dt [Drug Therapy] *clozapine/pd [Pharmacology] *selenium/cr [Drug Concentration] myocarditis/si [Side Effect] adult agranulocytosis/si [Side Effect] article blood sampling cardiomyopathy/si [Side Effect] catecholamine metabolism dietary intake female human major clinical study male oxidative stress priority journal risk benefit analysis *schizophrenia/di [Diagnosis] major clinical study myocarditis / side effect oxidative stress priority journal risk benefit analysis *schizophrenia / *diagnosis / *drug therapy selenium deficiency / side effect adult male trace metal blood level agranulocytosis / side effect article blood sampling cardiomyopathy / side effect catecholamine metabolism dietary intake female human |
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