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Title: | Genes on the X chromosome are important in undiagnosed mental retardation. | Authors: | Tonge B.;Turner G.;Partington M.;Mowat D.;Einfeld S. | Institution: | (Partington, Mowat, Turner) Hunter Genetics, Hunter Area Health Service, Newcastle, NSW, Australia (Tonge) Centre for Developmental Psychiatry, Monash Medical Centre, Monash University, Clayton, Vic., Australia (Partington) Hunter Genetics, PO Box 84, Waratah, NSW 2298, Australia | Issue Date: | 19-Oct-2012 | Copyright year: | 2000 | Publisher: | Wiley-Liss Inc. (111 River Street, Hoboken NJ 07030-5774, United States) | Place of publication: | United States | Publication information: | American Journal of Medical Genetics. 92 (1) (pp 57-61), 2000. Date of Publication: 01 May 2000. | Abstract: | The clinical genetic diagnosis was reviewed in 429 subjects with intellectual disability in the Australian Child and Adolescent Development (ACAD) study of behavioural problems. With minor differences, the overall 'general distribution by causation' was similar to that to that found by the Consensus Conference of the American College of Medical Genetics in 1995. There was a significant male excess in the whole series which was shown to reside in those with 'autism,' those with undiagnosed nonsyndromic mental retardation (NSMR) and those with X-linked monogenic disorders. It is argued that a substantial proportion of undiagnosed NSMR is caused by genes on the X chromosome. Some of the practical problems of assigning individuals to diagnostic groups are discussed. (C) 2000 Wiley-Liss, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/%28SICI%291096-8628%2820000501%2992:1%3C57 | PubMed URL: | 10797424 [http://www.ncbi.nlm.nih.gov/pubmed/?term=10797424] | ISSN: | 0148-7299 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/33316 | Type: | Article |
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