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Title: | Ondansetron is not superior to moderate dose metoclopramide in the prevention of post-operative nausea and vomiting after minor gynaecological surgery. | Authors: | Monagle J.;Hewitt M.;Goodchild C.;Barnes R. | Institution: | (Monagle, Barnes, Goodchild, Hewitt) Department of Anaesthesia, Monash Medical Center, Monash University, Clayton, Vic., Australia (Monagle) Department of Anaesthesia, Monash Medical Centre, Block E, 246 Clayton Road, Clayton, Vic. 3168, Australia | Issue Date: | 19-Oct-2012 | Copyright year: | 1997 | Publisher: | Lippincott Williams and Wilkins (250 Waterloo Road, London SE1 8RD, United Kingdom) | Place of publication: | United Kingdom | Publication information: | European Journal of Anaesthesiology. 14 (6) (pp 604-609), 1997. Date of Publication: November 1997. | Abstract: | Peri-operative nausea and vomiting (PONV), remain a considerable problem. Ondansetron is being promoted currently as the drug of choice for the prevention and treatment of PONV. Experiments to investigate efficacy of ondansetron in PONV have been made with placebo or single doses of other drugs, e.g. metoclopramide, and often with different anaesthetic regimes with different emetic potential. This study investigated the relative benefits, in the prevention of PONV, of ondansetron compared with metoclopramide used at a dose higher than used in previous studies. Ninety-six patients undergoing minor gynaecological surgery were randomized to receive either ondansetron 4 mg or metoclopramide 0.4 mg kg-1. The patients were then assessed in the recovery room, in the day ward prior to discharge and the following day for the occurrence of PONV. Emetic symptoms occurred in similar proportions of patients who received ondansetron and metoclopramide. Nausea scores were similar between the groups in the recovery ward and 24-h follow-ups but there were higher post-operative nausea scores in the ondansetron group in the day ward (P = 0.001). There were no significant side effects due to either drug. We conclude that moderate dose metoclopramide is an effective alternative to ondansetron in the control of PONV. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1097/00003643-199711000-00008 | PubMed URL: | 9466096 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9466096] | ISSN: | 0265-0215 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/33915 | Type: | Article | Subjects: | *nausea/pc [Prevention] postoperative complication randomized controlled trial recovery room restlessness/si [Side Effect] scoring system vertigo/si [Side Effect] *vomiting/co [Complication] *vomiting/dt [Drug Therapy] *vomiting/pc [Prevention] ward antiemetic agent/ae [Adverse Drug Reaction] antiemetic agent/ct [Clinical Trial] antiemetic agent/cm [Drug Comparison] antiemetic agent/do [Drug Dose] antiemetic agent/dt [Drug Therapy] *metoclopramide/ae [Adverse Drug Reaction] *metoclopramide/ct [Clinical Trial] *metoclopramide/cm [Drug Comparison] *metoclopramide/do [Drug Dose] *metoclopramide/dt [Drug Therapy] *ondansetron/ae [Adverse Drug Reaction] *ondansetron/ct [Clinical Trial] *ondansetron/cm [Drug Comparison] *ondansetron/dt [Drug Therapy] *gynecologic surgery adult ambulatory surgery article clinical trial controlled clinical trial controlled study drug efficacy female flushing headache/si [Side Effect] human hypertension/si [Side Effect] hypotension/si [Side Effect] major clinical study *nausea/co [Complication] *nausea/dt [Drug Therapy] human hypertension / side effect hypotension / side effect major clinical study *nausea / *complication / *drug therapy / *prevention postoperative complication randomized controlled trial recovery room restlessness / side effect article vertigo / side effect *vomiting / *complication / *drug therapy / *prevention ward ambulatory surgery adult scoring system clinical trial controlled clinical trial controlled study drug efficacy female flushing *gynecologic surgery headache / side effect |
Type of Clinical Study or Trial: | Randomised controlled trial |
Appears in Collections: | Articles |
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