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Title: | Age and follicular phase estradiol are better predictors of pregnancy outcome than luteinizing hormone in menotropin ovulation induction for anovulatory polycystic ovarian syndrome. | Authors: | McCloud P.I.;McQuinn B.;Burger H.G.;Healy D.L.;Kovacs G.T.;McDonald J.;McClure N. | Institution: | (McClure, McDonald, Kovacs, Healy, McCloud, McQuinn, Burger) Monash Medical Centre, Prince Henry's Inst. of Medical Res., 246 Clayton Road, Clayton, Vic. 3168, Australia | Issue Date: | 25-Oct-2012 | Copyright year: | 1993 | Publisher: | Elsevier Inc. (360 Park Avenue South, New York NY 10010, United States) | Place of publication: | United States | Publication information: | Fertility and Sterility. 59 (4) (pp 729-733), 1993. Date of Publication: 1993. | Abstract: | Objective: To examine the relationship of baseline and preovulatory serum E2, P, and LH levels and age with pregnancy outcome in polycystic ovarian syndrome (PCOS) patients undergoing hMG ovulation induction. Design(s): Retrospective analysis of all available data over 2 years. Setting(s): Tertiary referral ovulation induction clinic. Subjects: Forty-four anovulatory PCOS patients with 25 ovulatory nonconception and 50 conception cycles after hMG ovulation induction. Main Outcome Measure(s): Ovulation (midluteal serum P > 25 nmol/L [7.86 ng/mL]); pregnancy (serum beta-hCG > 30 mIU/mL 16 days after ovulating injection); pregnancy outcome: pregnancy termination < 20 weeks' or >=20 weeks' amenorrhea. Result(s): Of the endocrine parameters considered, none was significantly different in nonconceptive and conceptive ovulatory cycles. Miscarriage was associated with low basal serum E2: median value for pregnancies ending <20 weeks, 105 pmol/L (28.6 pg/mL) for >=20 weeks 150 pmol/L (40.9 pg/mL). It was also significantly associated with age. For patients > 29.5 years of age, (29.5 years, population mean age) a baseline E2 <= 140 pmol/L (38.2 pg/mL) had sensitivity 92%, specificity 54%, positive predictive value 65%, and negative predictive value 87% for the prediction of miscarriage. The nature of the previous cycle, the day of the cycle on which therapy commenced, and a past history of miscarriage were not related either to pregnancy outcome or to basal serum E2. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/S0015-0282(16)55850-6 | PubMed URL: | 8458487 [http://www.ncbi.nlm.nih.gov/pubmed/?term=8458487] | ISSN: | 0015-0282 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/34433 | Type: | Article | Subjects: | *chorionic gonadotropin/do [Drug Dose] *chorionic gonadotropin/dt [Drug Therapy] *chorionic gonadotropin/pd [Pharmacology] *estradiol/ec [Endogenous Compound] follitropin/ec [Endogenous Compound] *human menopausal gonadotropin/ad [Drug Administration] *human menopausal gonadotropin/do [Drug Dose] *human menopausal gonadotropin/dt [Drug Therapy] *luteinizing hormone/ec [Endogenous Compound] prasterone sulfate/ec [Endogenous Compound] *progesterone/ec [Endogenous Compound] *anovulation/dt [Drug Therapy] age article clinical article echography female follicular phase hormone blood level human intramuscular drug administration ovary follicle *ovary polycystic disease/di [Diagnosis] *ovary polycystic disease/dt [Drug Therapy] ovulation induction prediction *pregnancy priority journal radioimmunoassay spontaneous abortion *chorionic gonadotropin/ad [Drug Administration] ovary follicle *ovary polycystic disease / *diagnosis / *drug therapy ovulation induction prediction *pregnancy priority journal *anovulation / *drug therapy spontaneous abortion age radioimmunoassay article clinical article echography female follicular phase hormone blood level human intramuscular drug administration |
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