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Title: | Mycobacterium tuberculosis: Active disease and latent infection in a renal transplant cohort. | Authors: | Trauer J.M.;Williams J.;Mulley W.R.;Rogers B.A.;Jenkin G.A. ;Rafiei N. | Monash Health Department(s): | Infectious Diseases and Clinical Microbiology Nephrology |
Institution: | (Rafiei, Williams, Jenkin, Rogers) Monash Infectious Diseases, Monash Health, Melbourne, VIC, Australia (Mulley) Department of Nephrology, Monash Medical Centre, Melbourne, VIC, Australia (Mulley, Rogers) Department of Medicine, Centre for Inflammatory Diseases, Monash University, Melbourne, VIC, Australia (Trauer) School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia | Issue Date: | 6-Mar-2020 | Copyright year: | 2019 | Publisher: | Blackwell Publishing | Place of publication: | Australia | Publication information: | Nephrology. 24 (5) (pp 569-574), 2019. Date of Publication: 01 May 2019. | Journal: | Nephrology | Abstract: | Aim: Our aim was threefold: first, to determine the incidence of active TB in our cohort, second to investigate the risk factors for active TB and third, to understand current screening practices. The ultimate goal was to use our findings to inform development of local and national guidelines. Method(s): The records of all adult patients who underwent renal transplantation at our centre from 2005 to 2014 were retrospectively reviewed to assess current screening practices, the risks for and burden of active TB. Result(s): A total of 660 individuals underwent renal transplantation during this period, totalling 3647 person years of follow up. Two patients were diagnosed with active TB after renal transplant, resulting in an incidence of 55 per 100 000 person-years. Of 656 transplant recipients, 102 (15.5%) were born in high TB incidence countries and 89 (13.5%) had an interferon gamma release assay (IGRA) at any point. Individuals born in high TB risk countries had a much higher incidence of active TB (353 per 100 000 person-years). Ten individuals had positive IGRA tests, of whom two were treated for active TB, two received chemoprophylaxis and six were not treated. Conclusion(s): In the absence of formal guidelines, IGRA-based screening for LTBI was infrequently performed. Our data suggest that screening and treatment of renal transplant recipients born in high incidence countries is an important preventive measure.Copyright © 2018 Asian Pacific Society of Nephrology | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/nep.13386 | PubMed URL: | 29660203 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29660203] | ISSN: | 1320-5358 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/35395 | Type: | Article | Subjects: | *tuberculosis/co [Complication] night sweat/co [Complication] priority journal retrospective study risk assessment screening *tuberculosis/di [Diagnosis] Mycobacterium tuberculosis test kit isoniazid/dt [Drug Therapy] *tuberculosis/pc [Prevention] *tuberculosis/ep [Epidemiology] *tuberculosis/dt [Drug Therapy] adult article birthplace chemoprophylaxis cohort analysis coughing/co [Complication] disease burden female fever/co [Complication] follow up graft recipient high risk population human incidence infection risk interferon gamma release assay *kidney graft kidney transplantation major clinical study male middle aged tuberculosis/co night sweat/co screening tuberculosis Mycobacterium tuberculosis test kit isoniazid tuberculosis birthplace chemoprophylaxis coughing/co disease burden fever/co graft recipient high risk infection risk interferon gamma release assay kidney graft kidney transplantation night sweat / complication adult Article birthplace chemoprophylaxis cohort analysis coughing / complication disease burden female fever / complication follow up graft recipient high risk population human male priority journal retrospective study major clinical study kidney transplantation incidence middle aged *kidney graft screening *tuberculosis / *complication / *diagnosis / *drug therapy / *epidemiology / *prevention interferon gamma release assay infection risk risk assessment |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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