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Title: | Curtailing PCOS. | Authors: | Pena A.S.;Teede H.J. ;Witchel S.F. | Monash Health Department(s): | Endocrinology Diabetes and Vascular Medicine |
Institution: | (Witchel) Department of Pediatrics, Division of Pediatric Endocrinology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States (Teede) Department of Endocrinology and Diabetes, Monash Health, Clayton, VIC, Australia (Teede) Monash Centre for Health Research and Implementation, School of Public Health and Preventative Medicine, Monash University, Clayton, VIC, Australia (Pena) Discipline of Paediatrics, The University of Adelaide-Robinson Research Institute, North Adelaide, SA, Australia | Issue Date: | 23-Jan-2020 | Copyright year: | 2020 | Publisher: | Springer Nature | Place of publication: | United States | Publication information: | Pediatric Research. 87 (2) (pp 353-361), 2020. Date of Publication: 01 Jan 2020. | Journal: | Pediatric Research | Abstract: | Polycystic ovary syndrome (PCOS), characterized by hormonal imbalance and ovarian dysfunction, often starts during adolescence. Inconsistent diagnostic criteria, variable provider knowledge, and lack of consensus pose specific challenges for the care of women with PCOS. These factors encourage inaccurate diagnosis with both under and overdiagnosis. This unfavorable diagnostic experience exasperates affected women and limits timely opportunities for intervention to minimize associated comorbidities, especially during the transition from pediatric to adult care. Recognition of these issues in the care of adolescents and women with PCOS inspired the development of the International Evidence-Based PCOS Guidelines, which emphasize the prevention, screening, and treatment of PCOS across the reproductive lifespan. The Guidelines and accompanying meta-analyses focus on three major categories of associated comorbidities: (1) reproductive; (2) metabolic; and (3) psychological. With the exception of infertility, this article considers common manifestations and comorbidities associated with PCOS throughout the lifecycle. Healthy lifestyle interventions with prevention of excess weight gain comprise the primary intervention for all comorbidities. Hence, early identification of girls "at risk" for PCOS and those with PCOS is a priority. Extensive guidelines for provider and patient education aim to decrease the medical, psychosocial, and economic burdens attributable to PCOS and its associated comorbidities.Copyright © 2019, International Pediatric Research Foundation, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41390-019-0615-1 | PubMed URL: | 31627209 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31627209] | ISSN: | 0031-3998 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/35462 | Type: | Review | Subjects: | eating disorder adolescence amenorrhea anovulation anxiety disorder attributable risk body mass body weight gain cancer risk comorbidity depression endometrium cancer environmental factor epigenetics evidence based practice female infertility healthy lifestyle hirsutism human hyperandrogenism hyperglycemia impaired glucose tolerance insulin resistance maternal obesity meta analysis metabolic disorder mother fetus relationship non insulin dependent diabetes mellitus ovary insufficiency *ovary polycystic disease/di [Diagnosis] pathophysiology patient education physical disease by body function practice guideline pregnancy complication pregnancy diabetes mellitus priority journal psychological aspect quality of life review risk factor skin disease sleep disordered breathing transition to adult care androgen/ec [Endogenous Compound] estrogen/ec [Endogenous Compound] insulin/ec [Endogenous Compound] eating disorder adolescence amenorrhea anovulation anxiety disorder attributable risk body mass body weight gain cancer risk depression endometrium cancer environmental factor epigenetics evidence based practice infertility healthy lifestyle hirsutism hyperandrogenism hyperglycemia impaired glucose tolerance insulin resistance maternal obesity metabolic disorder mother fetus relationship non insulin dependent diabetes mellitus ovary insufficiency ovary polycystic disease pathophysiology patient education physical disease by body function practice guideline pregnancy pregnancy diabetes mellitus psychological aspect quality of life skin disease sleep disordered breathing transition to care androgen estrogen insulin comorbidity depression eating disorder endometrium cancer environmental factor epigenetics evidence based practice female infertility healthy lifestyle skin disease hirsutism human hyperandrogenism hyperglycemia impaired glucose tolerance insulin resistance maternal obesity meta analysis metabolic disorder mother fetus relationship non insulin dependent diabetes mellitus ovary insufficiency *ovary polycystic disease / *diagnosis pathophysiology patient education physical disease by body function practice guideline pregnancy diabetes mellitus sleep disordered breathing transition to adult care risk factor Review quality of life pregnancy complication adolescence amenorrhea anovulation anxiety disorder attributable risk body mass body weight gain cancer risk psychological aspect priority journal |
Type of Clinical Study or Trial: | Systematic review and/or meta-analysis |
Appears in Collections: | Articles |
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