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Title: | Associations between embryo grading and congenital malformations in IVF/ICSI pregnancies. | Authors: | Abel K.;Vollenhoven B. ;Osianlis T.;Finch S.;Healey M. | Monash Health Department(s): | Obstetrics and Gynaecology (Monash Women's) | Institution: | (Abel, Healey) Department of Obstetrics and Gynaecology, The Royal Women's Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia (Healey, Vollenhoven) Monash IVF, 252-256 Clayton Road, Clayton, VIC 3168, Australia (Healey) Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, VIC 3010, Australia (Finch) Statistical Consulting Centre, School of Mathematics and Statistics, The University of Melbourne, 139 Barry Street, Carlton, VIC 3053, Australia (Osianlis, Vollenhoven) Department of Obstetrics and Gynaecology, Monash University, Wellington Road, Clayton, VIC 3800, Australia (Vollenhoven) Women's Programme, Monash Health, 246 Clayton Road, Clayton, VIC 3168, Australia | Issue Date: | 8-Jan-2020 | Copyright year: | 2019 | Publisher: | Elsevier Ltd | Place of publication: | United Kingdom | Publication information: | Reproductive BioMedicine Online. 39 (6) (pp 981-989), 2019. Date of Publication: December 2019. | Journal: | Reproductive BioMedicine Online | Abstract: | Research question: Does the quality of transferred embryos have an impact on the rate of congenital malformations in IVF/intracytoplasmic sperm injection (ICSI)-conceived babies? Design: Retrospective cohort study involving 6637 pregnancies of >=20 weeks' gestation from women undergoing embryo transfer with a single Day 5 embryo at a private multisite IVF clinic between 2005 and 2015. Embryos were classified as good quality (n = 5537) or poor quality (n = 1100) based on an internal grading system of morphological parameters; malformation rates were compared. Result(s): In pregnancies proceeding to delivery (>=20 weeks' gestation), poor quality embryos were associated with increased odds of at least one anomaly (adjusted odds ratio [OR] 1.33, 95% confidence interval [CI] 1.03-1.71), major anomalies (adjusted OR 1.42, 95% CI 1.05-1.91), musculoskeletal anomalies (adjusted OR 2.09, 95% CI 1.35-3.22), particularly talipes (adjusted OR 2.88, 95% CI 1.33-6.25), and the International Classification of Diseases (ICD) classification 'Other congenital malformations' (adjusted OR 2.34, 95% CI 1.13-4.34). Furthermore, for pregnancies >=9 weeks' gestation, poor embryos had more than double the odds of chromosomal anomalies than good embryos (adjusted OR 2.33, 95% CI 1.30-4.18, P = 0.005). Conclusion(s): This is the first study to compare the rates of individual congenital malformations for good and poor quality embryos. It provides insight into potential risks of transferring poor quality embryos. In pregnancies >=20 weeks' gestation, poor quality Day 5 embryos are associated with major malformations, at least one anomaly, musculoskeletal anomalies, talipes and the ICD classification 'Other congenital malformations'. In pregnancies >=9 weeks' gestation, poor quality Day 5 embryos are associated with chromosomal anomalies.Copyright © 2019 Reproductive Healthcare Ltd. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.rbmo.2019.07.035 | PubMed URL: | 31606300 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31606300] | ISSN: | 1472-6483 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/35471 | Type: | Article | Subjects: | hypospadias/cn [Congenital Disorder] ICD-10 *in vitro fertilization major clinical study Mongolian spot/cn [Congenital Disorder] neural tube defect/cn [Congenital Disorder] obstetric delivery polydactyly/cn [Congenital Disorder] pregnancy retrospective study *single embryo transfer skin hemangioma/cn [Congenital Disorder] stillbirth syndactyly/cn [Congenital Disorder] umbilical hernia/cn [Congenital Disorder] *intracytoplasmic sperm injection abdominal wall hernia/cn [Congenital Disorder] ankyloglossia/cn [Congenital Disorder] article cleft lip palate/cn [Congenital Disorder] cohort analysis *congenital malformation controlled study cryptorchism/cn [Congenital Disorder] diaphragm hernia/cn [Congenital Disorder] disease association embryo female foot malformation/cn [Congenital Disorder] hip dysplasia/cn [Congenital Disorder] human hydrocephalus/cn [Congenital Disorder] hydronephrosis/cn [Congenital Disorder] hypospadias ICD-10 in vitro fertilization Mongolian spot neural tube defect obstetric delivery polydactyly pregnancy single embryo transfer skin hemangioma stillbirth syndactyly umbilical hernia intracytoplasmic sperm injection abdominal wall hernia ankyloglossia cleft lip palate congenital malformation cryptorchism diaphragm hernia embryo foot malformation hip dysplasia hydrocephalus hydronephrosis female foot malformation / congenital disorder hip dysplasia / congenital disorder human hydrocephalus / congenital disorder hydronephrosis / congenital disorder hypospadias / congenital disorder ICD-10 *in vitro fertilization *intracytoplasmic sperm injection major clinical study Mongolian spot / congenital disorder neural tube defect / congenital disorder obstetric delivery polydactyly / congenital disorder pregnancy retrospective study *single embryo transfer skin hemangioma / congenital disorder stillbirth ankyloglossia / congenital disorder umbilical hernia / congenital disorder abdominal wall hernia / congenital disorder syndactyly / congenital disorder Article cleft lip palate / congenital disorder cohort analysis *congenital malformation controlled study cryptorchism / congenital disorder diaphragm hernia / congenital disorder disease association embryo |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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