Shared heritability and functional enrichment across six solid cancers.

Fletcher O.; Tardon A.; Taylor J.A.; Teare M.D.; Teixeira M.R.; Terry M.B.; Terry K.L.; Thibodeau S.N.; Thomassen M.; Bjorge L.; Tischkowitz M.; Toland A.E.; Torres D.; Townsend P.A.; Travis R.C.; Tung N.; Tworoger S.S.; Ulrich C.M.; Usmani N.; Vachon C.M.; Van Nieuwenhuysen E.; Vega A.; Aguado-Barrera M.E.; Wang Q.; Webb P.M.; Weinberg C.R.; Weinstein S.; Weissler M.C.; Weitzel J.N.; West C.M.L.; White E.; Whittemore A.S.; Wichmann H.-E.; Wiklund F.; Winqvist R.; Wolk A.; Woll P.; Woods M.; Wu A.H.; Wu X.; Yannoukakos D.; Zheng W.; Zienolddiny S.; Ziogas A.; Zorn K.K.; Lane J.M.; Saxena R.; Thomas D.; Hung R.J.; Diergaarde B.; McKay J.; Peters U.; Hsu L.; Garcia-Closas M.; Eeles R.A.; Chenevix-Trench G.; Brennan P.J.; Haiman C.A.; Simard J.; Easton D.F.; Gruber S.B.; Pharoah P.D.P.; Price A.L.; Pasaniuc B.; Amos C.I.; Kraft P.; Lindstrom S.; Chen C.; Anton-Culver H.; Antoniou A.C.; Antonenkova N.N.; Arnold S.M.; Jiang X.; Finucane H.K.; Schumacher F.R.; Schmit S.L.; Tyrer J.P.; Han Y.; Michailidou K.; Lesseur C.; Kuchenbaecker K.B.; Dennis J.; Conti D.V.; Casey G.; Gaudet M.M.; Huyghe J.R.; Albanes D.; Aldrich M.C.; Andrew A.S.; Andrulis I.L.; Aronson K.J.; Arun B.K.; Bandera E.V.; Barkardottir R.B.; Barnes D.R.; Batra J.; Beckmann M.W.; Benitez J.; Benlloch S.; Berchuck A.; Berndt S.I.; Bickeboller H.; Bien S.A.; Blomqvist C.; Boccia S.; Bogdanova N.V.; Bojesen S.E.; Bolla M.K.; Brauch H.; Brenner H.; Brenton J.D.; Brook M.N.; Brunet J.; Brunnstrom H.; Buchanan D.D.; Burwinkel B.; Butzow R.; Cadoni G.; Caldes T.; Caligo M.A.; Campbell I.; Campbell P.T.; Cancel-Tassin G.; Cannon-Albright L.; Campa D.; Caporaso N.; Carvalho A.L.; Chan A.T.; Chang-Claude J.; Chanock S.J.; Christiani D.C.; Claes K.B.M.; Claessens F.; Clements J.; Collee J.M.; Correa M.C.; Couch F.J.; Cox A.; Cunningham J.M.; Cybulski C.; Czene K.; Daly M.B.; deFazio A.; Devilee P.; Diez O.; Gago-Dominguez M.; Donovan J.L.; Dork T.; Duell E.J.; Dunning A.M.; Dwek M.; Eccles D.M.; Edlund C.K.; Edwards D.R.V.; Ellberg C.; Evans D.G.; Fasching P.A.; Ferris R.L.; Liloglou T.; Figueiredo J.C.; Fortner R.T.; Fostira F.; Franceschi S.; Friedman E.; Gallinger S.J.; Ganz P.A.; Garber J.; Garcia-Saenz J.A.; Gayther S.A.; Giles G.G.; Godwin A.K.; Goldberg M.S.; Goldgar D.E.; Goode E.L.; Goodman M.T.; Goodman G.; Grankvist K.; Greene M.H.; Gronberg H.; Gronwald J.; Guenel P.; Hakansson N.; Hall P.; Hamann U.; Hamdy F.C.; Hamilton R.J.; Hampe J.; Haugen A.; Heitz F.; Herrero R.; Hillemanns P.; Hoffmeister M.; Hogdall E.; Hong Y.-C.; Hopper J.L.; Houlston R.; Hulick P.J.; Hunter D.J.; Huntsman D.G.; Idos G.; Imyanitov E.N.; Ingles S.A.; Isaacs C.; Jakubowska A.; James P.; Jenkins M.A.; Johansson M.; John E.M.; Joshi A.D.; Kaneva R.; Karlan B.Y.; Kelemen L.E.; Kuhl T.; Khaw K.-T.; Khusnutdinova E.; Kibel A.S.; Kiemeney L.A.; Kim J.; Kjaer S.K.; Knight J.A.; Kogevinas M.; Kote-Jarai Z.; Koutros S.; Kristensen V.N.; Kupryjanczyk J.; Lacko M.; Lam S.; Lambrechts D.; Landi M.T.; Lazarus P.; Le N.D.; Lee E.; Lejbkowicz F.; Lenz H.-J.; Leslie G.; Lessel D.; Lester J.; Levine D.A.; Li L.; Li C.I.; Lindblom A.; Lindor N.M.; Liu G.; Loupakis F.; Lubinski J.; Maehle L.; Maier C.; Mannermaa A.; Marchand L.L.; Margolin S.; May T.; McGuffog L.; Meindl A.; Middha P.; Miller A.; Milne R.L.; MacInnis R.J.; Modugno F.; Montagna M.; Moreno V.; Moysich K.B.; Mucci L.; Muir K.; Mulligan A.M.; Nathanson K.L.; Neal D.E.; Ness A.R.; Neuhausen S.L.; Nevanlinna H.; Newcomb P.A.; Newcomb L.F.; Nielsen F.C.; Nikitina-Zake L.; Nordestgaard B.G.; Nussbaum R.L.; Offit K.; Olah E.; Olama A.A.A.; Olopade O.I.; Olshan A.F.; Olsson H.; Osorio A.; Pandha H.; Park J.Y.; Pashayan N.; Parsons M.T.; Pejovic T.; Penney K.L.; Peters W.H.M.; Phelan C.M.; Phipps A.I.; Plaseska-Karanfilska D.; Pring M.; Prokofyeva D.; Radice P.; Stefansson K.; Ramus S.J.; Raskin L.; Rennert G.; Rennert H.S.; van Rensburg E.J.; Riggan M.J.; Risch H.A.; Risch A.; Roobol M.J.; Rosenstein B.S.; Rossing M.A.; De Ruyck K.; Saloustros E.; Sandler D.P.; Sawyer E.J.; Schabath M.B.; Schleutker J.; Schmidt M.K.; Setiawan V.W.; Shen H.; Siegel E.M.; Sieh W.; Singer C.F.; Slattery M.L.; Sorensen K.D.; Southey M.C.; Spurdle A.B.; Stanford J.L.; Stevens V.L.; Stintzing S.; Stone J.; Sundfeldt K.; Sutphen R.; Swerdlow A.J.; Tajara E.H.; Tangen C.M.

Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/35586

Title:	Shared heritability and functional enrichment across six solid cancers.
Authors:	Fletcher O.;Tardon A.;Taylor J.A.;Teare M.D.;Teixeira M.R.;Terry M.B.;Terry K.L.;Thibodeau S.N.;Thomassen M.;Bjorge L.;Tischkowitz M.;Toland A.E.;Torres D.;Townsend P.A.;Travis R.C.;Tung N.;Tworoger S.S.;Ulrich C.M.;Usmani N.;Vachon C.M.;Van Nieuwenhuysen E.;Vega A.;Aguado-Barrera M.E.;Wang Q.;Webb P.M.;Weinberg C.R.;Weinstein S.;Weissler M.C.;Weitzel J.N.;West C.M.L.;White E.;Whittemore A.S.;Wichmann H.-E.;Wiklund F.;Winqvist R.;Wolk A.;Woll P.;Woods M.;Wu A.H.;Wu X.;Yannoukakos D.;Zheng W.;Zienolddiny S.;Ziogas A.;Zorn K.K.;Lane J.M.;Saxena R.;Thomas D.;Hung R.J.;Diergaarde B.;McKay J.;Peters U.;Hsu L.;Garcia-Closas M.;Eeles R.A.;Chenevix-Trench G.;Brennan P.J.;Haiman C.A.;Simard J.;Easton D.F.;Gruber S.B.;Pharoah P.D.P.;Price A.L.;Pasaniuc B.;Amos C.I.;Kraft P.;Lindstrom S.;Chen C. ;Anton-Culver H.;Antoniou A.C.;Antonenkova N.N.;Arnold S.M.;Jiang X.;Finucane H.K.;Schumacher F.R.;Schmit S.L.;Tyrer J.P.;Han Y.;Michailidou K.;Lesseur C.;Kuchenbaecker K.B.;Dennis J.;Conti D.V.;Casey G.;Gaudet M.M.;Huyghe J.R.;Albanes D.;Aldrich M.C.;Andrew A.S.;Andrulis I.L.;Aronson K.J.;Arun B.K.;Bandera E.V.;Barkardottir R.B.;Barnes D.R.;Batra J.;Beckmann M.W.;Benitez J.;Benlloch S.;Berchuck A.;Berndt S.I.;Bickeboller H.;Bien S.A.;Blomqvist C.;Boccia S.;Bogdanova N.V.;Bojesen S.E.;Bolla M.K.;Brauch H.;Brenner H.;Brenton J.D.;Brook M.N.;Brunet J.;Brunnstrom H.;Buchanan D.D.;Burwinkel B.;Butzow R.;Cadoni G.;Caldes T.;Caligo M.A.;Campbell I.;Campbell P.T.;Cancel-Tassin G.;Cannon-Albright L.;Campa D.;Caporaso N.;Carvalho A.L.;Chan A.T.;Chang-Claude J.;Chanock S.J.;Christiani D.C.;Claes K.B.M.;Claessens F.;Clements J.;Collee J.M.;Correa M.C.;Couch F.J.;Cox A.;Cunningham J.M.;Cybulski C.;Czene K.;Daly M.B.;deFazio A.;Devilee P.;Diez O.;Gago-Dominguez M.;Donovan J.L.;Dork T.;Duell E.J.;Dunning A.M.;Dwek M.;Eccles D.M.;Edlund C.K.;Edwards D.R.V.;Ellberg C.;Evans D.G.;Fasching P.A.;Ferris R.L.;Liloglou T.;Figueiredo J.C.;Fortner R.T.;Fostira F.;Franceschi S.;Friedman E.;Gallinger S.J.;Ganz P.A.;Garber J.;Garcia-Saenz J.A.;Gayther S.A.;Giles G.G.;Godwin A.K.;Goldberg M.S.;Goldgar D.E.;Goode E.L.;Goodman M.T.;Goodman G.;Grankvist K.;Greene M.H.;Gronberg H.;Gronwald J.;Guenel P.;Hakansson N.;Hall P.;Hamann U.;Hamdy F.C.;Hamilton R.J.;Hampe J.;Haugen A.;Heitz F.;Herrero R.;Hillemanns P.;Hoffmeister M.;Hogdall E.;Hong Y.-C.;Hopper J.L.;Houlston R.;Hulick P.J.;Hunter D.J.;Huntsman D.G.;Idos G.;Imyanitov E.N.;Ingles S.A.;Isaacs C.;Jakubowska A.;James P.;Jenkins M.A.;Johansson M.;John E.M.;Joshi A.D.;Kaneva R.;Karlan B.Y.;Kelemen L.E.;Kuhl T.;Khaw K.-T.;Khusnutdinova E.;Kibel A.S.;Kiemeney L.A.;Kim J.;Kjaer S.K.;Knight J.A.;Kogevinas M.;Kote-Jarai Z.;Koutros S.;Kristensen V.N.;Kupryjanczyk J.;Lacko M.;Lam S.;Lambrechts D.;Landi M.T.;Lazarus P.;Le N.D.;Lee E.;Lejbkowicz F.;Lenz H.-J.;Leslie G.;Lessel D.;Lester J.;Levine D.A.;Li L.;Li C.I.;Lindblom A.;Lindor N.M.;Liu G.;Loupakis F.;Lubinski J.;Maehle L.;Maier C.;Mannermaa A.;Marchand L.L.;Margolin S.;May T.;McGuffog L.;Meindl A.;Middha P.;Miller A.;Milne R.L.;MacInnis R.J.;Modugno F.;Montagna M.;Moreno V.;Moysich K.B.;Mucci L.;Muir K.;Mulligan A.M.;Nathanson K.L.;Neal D.E.;Ness A.R.;Neuhausen S.L.;Nevanlinna H.;Newcomb P.A.;Newcomb L.F.;Nielsen F.C.;Nikitina-Zake L.;Nordestgaard B.G.;Nussbaum R.L.;Offit K.;Olah E.;Olama A.A.A.;Olopade O.I.;Olshan A.F.;Olsson H.;Osorio A.;Pandha H.;Park J.Y.;Pashayan N.;Parsons M.T.;Pejovic T.;Penney K.L.;Peters W.H.M.;Phelan C.M.;Phipps A.I.;Plaseska-Karanfilska D.;Pring M.;Prokofyeva D.;Radice P.;Stefansson K.;Ramus S.J.;Raskin L.;Rennert G.;Rennert H.S.;van Rensburg E.J.;Riggan M.J.;Risch H.A.;Risch A.;Roobol M.J.;Rosenstein B.S.;Rossing M.A.;De Ruyck K.;Saloustros E.;Sandler D.P.;Sawyer E.J.;Schabath M.B.;Schleutker J.;Schmidt M.K.;Setiawan V.W.;Shen H.;Siegel E.M.;Sieh W.;Singer C.F.;Slattery M.L.;Sorensen K.D.;Southey M.C.;Spurdle A.B.;Stanford J.L.;Stevens V.L.;Stintzing S.;Stone J.;Sundfeldt K.;Sutphen R.;Swerdlow A.J.;Tajara E.H.;Tangen C.M.
Institution:	(Jiang, Hunter, Price, Kraft) Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States (Jiang) Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels vagen 13, Stockholm 17177, Sweden (Finucane, Christiani, Joshi, Mucci, Tworoger, Price, Kraft) Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States (Finucane, Lane, Saxena, Price) Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, 75 Ames St, Cambridge, MA 02142, United States (Schumacher) Department of Population and Quantitative Health Sciences, Case Western Reserve University, 10900 Eucid Avenue, Cleveland, OH 44106, United States (Schumacher) Seidman Cancer Center, University Hospitals, Cleveland, OH 44106, United States (Schmit, Siegel) Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr. MRC-CANCONT, Tampa, FL 33612, United States (Schmit) Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr. MRC-CANCONT, Tampa, FL 33612, United States (Tyrer, Dunning, Easton, Pharoah) Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Worts' Causeway, Cambridge CB1 8RN, United Kingdom (Han) Department of Biomedical Data Science, The Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756, United States (Michailidou, Dennis, Antoniou, Barnes, Benlloch, Bolla, Leslie, McGuffog, Olama, Wang, Easton, Pharoah) Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts' Causeway, Cambridge CB1 8RN, United Kingdom (Michailidou) Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, Nicosia 1683, Cyprus (Lesseur) Genetic Epidemiology Group, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon 69008, France (Lesseur, Johansson, Brennan) Section of Genetics, International Agency for Research on Cancer, 150 cours Albert Thomas, Lyon 69008, France (Kuchenbaecker) Division of Psychiatry, University College London, Maple House, 149 Tottenham Court Road, London W1T 7NF, United Kingdom (Kuchenbaecker) UCL Genetics Institute, University College London, Gower Street, London WC1E 6BT, United Kingdom (Conti, Idos, Ingles, Haiman) Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 48109, United States (Casey) Public Health Sciences, University of Virginia, P.O. Box 800717, Charlottesville, VA 22908, United States (Casey) Center for Public Health Genomics, University of Virginia, P.O. Box 800717, Charlottesville, VA 22908, United States (Gaudet, Campbell, Stevens) Epidemiology Research Program, American Cancer Society, 250 Williams Street NW, Atlanta, GA 30303, United States (Huyghe, Bien, Newcomb, Newcomb, Phipps, Stanford, Ulrich, Hsu, Lindstrom) Public Health Sciences Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109-1024, United States (Albanes, Berndt, Caporaso, Chanock, Weinstein, Garcia-Closas) Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Dr, Rockville, MD 20850, United States (Aldrich) Department of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, 609 Oxford House, Nashville, TN 37232, United States (Andrew) Department of Neurology, Dartmouth-Hitchcock Medical Center, 7927 Rubin Building, Room 860, One Medical Center Drive, Lebanon, NH 3756, United States (Andrulis) Fred ALitwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G1X5, Canada (Andrulis) Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON M5S1A8, Canada (Anton-Culver, Ziogas) Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, 224 Irvine Hall, Irvine, CA 92617, United States (Antonenkova, Bogdanova) NNAlexandrov Research Institute of Oncology and Medical Radiology, Settlement of Lesnoy-2, Minsk 223040, Belarus (Arnold) Markey Cancer Center, University of Kentucky, 800 Rose Street, cc445, Lexington, KY 40508, United States (Aronson) Department of Public Health Sciences, and Cancer Research Institute, Queen's University, 10 Stuart Street, Kingston, ON K7L 3N6, Canada (Arun) Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, 1155 Pressler St, Houston, TX 77030, United States (Bandera) Cancer Prevention and Control Program, Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, Room 5568, New Brunswick, NJ 08903, United States (Barkardottir) Department of Pathology, Landspitali University Hospital, Hringbraut, Reykjavik 101, Iceland (Barkardottir) BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Vatnsmyrarvegi 16, Reykjavik 101, Iceland (Batra, Clements) Australian Prostate Cancer Research Centre-Qld, Translational Research Institute, 37 Kent St, Woolloongabba, QLD 4102, Australia (Batra, Clements) Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia (Beckmann, Fasching) Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen Nuremberg, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Universitaetsstrasse 21-23, Erlangen 91054, Germany (Benitez, Osorio) Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernandez Almagro, 3, Madrid 28029, Spain (Benitez, Kogevinas, Osorio, Vega) Biomedical Network on Rare Diseases (CIBERER), AvMonforte de Lemos, 3-5Pabellon 11Planta 0, Madrid 28029, Spain (Benlloch, Brook, Kote-Jarai, Swerdlow, Eeles) Division of Genetics and Epidemiology, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, United Kingdom (Berchuck, Riggan) Department of Obstetrics and Gynecology, Duke University Medical Center, 25171 Morris Bldg, Durham, NC 27710, United States (Bickeboller) Department of Genetic Epidemiology, University Medical Center Goettingen, Humboldtallee 32, Goettingen 37073, Germany (Bien, Newcomb) School of Public Health, University of Washington, 1959 NE Pacific Street, Health Science Buidling, F-350, Seattle, WA 98195, United States (Blomqvist) Department of Oncology, Helsinki University Hospital, University of Helsinki, Haartmaninkatu 4, Helsinki 00290, Finland (Blomqvist) Department of Oncology, Orebro University Hospital, Orebro 70185, Sweden (Boccia, Cadoni) Fondazione Policlinico Universitario AGemelli IRCCS, Roma 00168, Italy (Boccia, Cadoni) Universita Cattolica del Sacro Cuore, Roma 00168, Italy (Bogdanova) Department of Radiation Oncology, Hannover Medical School, Carl-Neuberg-Strase 1, Hannover 30625, Germany (Bogdanova, Dork, Hillemanns) Gynaecology Research Unit, Hannover Medical School, Carl-Neuberg-Strase 1, Hannover 30625, Germany (Bojesen, Nordestgaard) Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev 2730, Denmark (Bojesen, Nordestgaard) Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev Ringvej 75, Herlev 2730, Denmark (Bojesen, Nordestgaard) Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen 2200, Denmark (Brauch) DrMargarete Fischer-Bosch-Institute of Clinical Pharmacology, Auerbachstr112, Stuttgart 70376, Germany (Brauch) University of Tubingen, Geschwister-Scholl-Platz, Tubingen 72074, Germany (Brauch, Brenner) German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany (Brenner, Hoffmeister) Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany (Brenner) Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Im Neuenheimer Feld 280, Heidelberg 69120, Germany (Brenton, Neal) Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, United Kingdom (Brunet) Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigacio Biomedica de Girona), Catalan Institute of Oncology, CIBERONC, AvFranca s/n, Girona 17007, Spain (Brunnstrom) Clinical Sciences, Lund University, Box 117, Lund 221 00, Sweden (Brunnstrom) Department of Genetics and Pathology, Division of Laboratory Medicine, Lund 221 85, Sweden (Buchanan, Jenkins) University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, VIC 3010, Australia (Buchanan) Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, VIC 3010, Australia (Buchanan) Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, VIC 3010, Australia (Burwinkel) Department of Obstetrics and Gynecology, University of Heidelberg, Im Neuenheimer Feld 440, Heidelberg 69120, Germany (Burwinkel) Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany (Butzow) Department of Pathology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki 4th floor, Haartmaninkatu 8, Helsinki 00029, Finland (Caldes, Garcia-Saenz) Medical Oncology Department, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria San Carlos (IdISSC), Centro Investigacion Biomedica en Red de Cancer (CIBERONC), Calle del Prof Martin Lagos, Madrid 28040, Spain (Caligo) Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, via Roma 67, Pisa 56126, Italy (Campbell) Peter MacCallum Cancer Center, 305 Grattan Street, Melbourne, VIC 3000, Australia (Campbell, James) Sir Peter MacCallum Department of Oncology, The University of Melbourne, 305 Grattan Street, Melbourne, VIC 3000, Australia (Cancel-Tassin) Sorbonne Universite, GRC Ndegree5 ONCOTYPE-URO, Tenon Hospital, Paris 75020, France (Cancel-Tassin) CeRePP, Tenon Hospital, Paris 75020, France (Cannon-Albright) Division of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT 84112, United States (Cannon-Albright) George EWahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT 84112, United States (Campa, Chang-Claude, Fortner, Middha) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany (Campa) Department of Biology, University of Pisa, Pisa 56126, Italy (Carvalho) Molecular Oncology Research Center, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331, Barretos, SP 784-400, Brazil (Carvalho) Head and Neck Surgery Department, Barretos Cancer Hospital, Pio XII, 1331, Antenor Duarte Villela St, Barretos, SP 14784-400, Brazil (Chan) Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States (Chan, Penney) Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, United States (Chang-Claude) Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Martinistrase 52, Hamburg 20246, Germany (Chen, Rossing) Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, United States (Claes) Centre for Medical Genetics, Ghent University, De Pintelaan 185, Gent 9000, Belgium (Claessens) Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven 3000, Belgium (Collee) Department of Clinical Genetics, Erasmus University Medical Center, Wytemaweg 80, Rotterdam, CN 3015, Netherlands (Correa) University of Puerto Rico Medical Sciences Campus and Comprehensive Cancer Center, San Juan, PR 00936, United States (Couch, Cunningham, Thibodeau) Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First StSW, Rochester, MN 55905, United States (Cox) Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom (Cybulski, Gronwald, Jakubowska, Lubinski) International Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, ulUnii Lubelskiej 1, Szczecin 71-252, Poland (Czene, Gronberg, Hall, Wiklund) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska Univ Hospital, Stockholm 171 76, Sweden (Daly) Department of Clinical Genetics, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, United States (deFazio) Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, 176 Hawkesbury Rd, Sydney, NSW 2145, Australia (deFazio) Department of Gynaecological Oncology, Westmead Hospital, Hawkesbury Rd & Darcy Rd, Sydney, NSW 2145, Australia (Devilee) Department of Pathology, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, Netherlands (Devilee) Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden 2333 ZA, Netherlands (Diez) Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Passeig de la Vall d'Hebron 119-129, Barcelona 08035, Spain (Gago-Dominguez) Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Travesia da Choupana S/N, Santiago de Compostela 15706, Spain (Gago-Dominguez) Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, La Jolla, CA 92037, United States (Donovan) School of Social and Community Medicine, University of Bristol, Bristol BS8 1TH, United Kingdom (Duell) Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), AvGran Via 199-203, L'Hospitalet de Llobregat, Barcelona 08908, Spain (Dwek) Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, 309 Regent Street, London W1B 2HW, United Kingdom (Eccles) Cancer 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[Ovid has truncated this field to avoid Excel character limitations]
Issue Date:	28-Feb-2019
Copyright year:	2019
Publisher:	Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom)
Place of publication:	United Kingdom
Publication information:	Nature Communications. 10 (1) (no pagination), 2019. Article Number: 431. Date of Publication: 01 Dec 2019.
Journal:	Nature Communications
Abstract:	Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 x 10-8), breast and ovarian cancer (rg = 0.24, p = 7 x 10-5), breast and lung cancer (rg = 0.18, p =1.5 x 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 x 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.Copyright © 2019, The Author(s).
DOI:	http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41467-018-08054-4
PubMed URL:	30683880 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30683880]
ISSN:	2041-1723 (electronic)
URI:	https://repository.monashhealth.org/monashhealthjspui/handle/1/35586
Type:	Article
Appears in Collections:	Articles

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