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Title: | NOACs Now Mainstream for the Use of Anticoagulation in Non-Valvular Atrial Fibrillation in Australia. | Authors: | Bittinger L.;Pol D.;Curtis C.;Ramkumar S. | Institution: | (Pol, Ramkumar, Bittinger) Monash Heart, Monash Medical Centre, Melbourne, Vic, Australia (Curtis) West Gippsland Hospital, Melbourne, Vic, Australia | Issue Date: | 15-Mar-2019 | Copyright year: | 2019 | Publisher: | Elsevier Ltd | Place of publication: | United Kingdom | Publication information: | Heart Lung and Circulation. 28 (4) (pp e40-e42), 2019. Date of Publication: April 2019. | Journal: | Heart Lung and Circulation | Abstract: | The management of stroke risk in patients with non-valvular atrial fibrillation has changed over the past few years. This change has occurred due to the introduction of novel oral anticoagulants (NOACs) such as apixaban, rivaroxaban and dabigatran for the management of non-valvular atrial fibrillation. These agents have shown comparable stroke risk reduction to warfarin in large international multicentre trials [1-3]. This has changed the clinical practice of many treating physicians since their introduction from 2011 to 2013. The purpose of this review was to highlight the now mainstream use of NOAC administration in preference to warfarin, by comparing the trends in the number of prescriptions filled since all three forms of oral anti-coagulant became available in 2013. These agents are being increasingly prescribed due to their ease of use compared to warfarin, which not only requires ongoing monitoring due to narrow therapeutic range but also has many drug and food interactions. Since November 2015, NOACs have become the mainstream choice for anticoagulation in atrial fibrillation likely given their ease of use compared to warfarin. The use of each anticoagulant remains divergent with the use of warfarin continuing to decrease.Copyright © 2018 | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.hlc.2018.03.010 | PubMed URL: | 29861320 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29861320] | ISSN: | 1443-9506 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/35758 | Type: | Article | Subjects: | *Australia cerebrovascular accident/dt [Drug Therapy] cerebrovascular accident/pc [Prevention] deep vein thrombosis/dt [Drug Therapy] drug surveillance program food drug interaction human anticoagulant therapy article *atrial fibrillation/dt [Drug Therapy] lung embolism/dt [Drug Therapy] prescription priority journal treatment indication trend study *anticoagulant agent/cm [Drug Comparison] *anticoagulant agent/dt [Drug Therapy] *anticoagulant agent/po [Oral Drug Administration] apixaban/cm [Drug Comparison] apixaban/dt [Drug Therapy] apixaban/po [Oral Drug Administration] dabigatran/cm [Drug Comparison] dabigatran/dt [Drug Therapy] dabigatran/po [Oral Drug Administration] rivaroxaban/cm [Drug Comparison] rivaroxaban/dt [Drug Therapy] rivaroxaban/po [Oral Drug Administration] warfarin/cm [Drug Comparison] warfarin/dt [Drug Therapy] warfarin/po [Oral Drug Administration] lung embolism / drug therapy prescription trend study treatment indication priority journal anticoagulant therapy Article *atrial fibrillation / *drug therapy *Australia cerebrovascular accident / drug therapy / prevention deep vein thrombosis / drug therapy drug surveillance program food drug interaction human |
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