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Title: | Sarcopenia and type 2 diabetes mellitus: A bidirectional relationship. | Authors: | Mesinovic J.;Scott D. ;Ebeling P.R. ;De Courten B. ;Zengin A. | Institution: | (Mesinovic, Zengin, Ebeling, Scott) Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Melbourne, VIC, Australia (De Courten) Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton, Melbourne, VIC, Australia (Ebeling, Scott) Australian Institute for Musculoskeletal Science (AIMSS), Department of Medicine-Western Health, Melbourne Medical School, The University of Melbourne, St Albans, Melbourne, VIC, Australia | Issue Date: | 4-Sep-2019 | Copyright year: | 2019 | Publisher: | Dove Medical Press Ltd. (PO Box 300-008, Albany, Auckland, New Zealand) | Place of publication: | New Zealand | Publication information: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12 (pp 1057-1072), 2019. Date of Publication: 2019. | Journal: | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | Abstract: | The incidence and prevalence of metabolic and musculoskeletal diseases are increasing. Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, inflammation, advanced glycation end-product accumulation and increased oxidative stress. These characteristics can negatively affect various aspects of muscle health, including muscle mass, strength, quality and function through impairments in protein metabolism, vascular and mitochondrial dysfunction, and cell death. Sarcopenia is a term used to describe the age-related loss in skeletal muscle mass and function and has been implicated as both a cause and consequence of T2DM. Sarcopenia may contribute to the development and progression of T2DM through altered glucose disposal due to low muscle mass, and also increased localized inflammation, which can arise through inter-and intramuscular adipose tissue accumulation. Lifestyle modifications are important for improving and maintaining mobility and metabolic health in individuals with T2DM and sarcopenia. However, evidence for the most effective and feasible exercise and dietary interventions in this population is lacking. In this review, we discuss the current literature highlighting the bidirectional relationship between T2DM and sarcopenia, highlight current research gaps and treatments, and provide recommendations for future research.Copyright © 2019 Mesinovic et al. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2147/DMSO.S186600 | ISSN: | 1178-7007 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/36018 | Type: | Review | Subjects: | *sarcopenia/pc [Prevention] cytokine receptor antagonist/dt [Drug Therapy] adipose tissue caloric restriction clinical research diabetic complication/co [Complication] disease association exercise human inflammation insulin resistance insulin treatment microangiopathy/co [Complication] muscle mass muscle strength muscle tissue *non insulin dependent diabetes mellitus/dt [Drug Therapy] *non insulin dependent diabetes mellitus/pc [Prevention] *non insulin dependent diabetes mellitus/th [Therapy] nonhuman oxidative stress physical activity physical performance prophylaxis resistance training review *sarcopenia/dt [Drug Therapy] antidiabetic agent/dt [Drug Therapy] *sarcopenia/th [Therapy] vascular disease/co [Complication] activin/dt [Drug Therapy] advanced glycation end product/ec [Endogenous Compound] prophylaxis resistance training Review *sarcopenia / *drug therapy / *prevention / *therapy vascular disease / complication physical activity oxidative stress nonhuman *non insulin dependent diabetes mellitus / *drug therapy / *prevention / *therapy muscle tissue muscle strength microangiopathy / complication insulin resistance disease association diabetic complication / complication clinical research caloric restriction adipose tissue muscle mass insulin treatment physical performance inflammation human exercise |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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