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Title: | Surveillance of life-long antibiotics-A cross-sectional cohort study assessing patient attitudes and understanding of long-term antibiotic consumption. | Authors: | Streitberg R.;Woolley I. ;Korman T. ;Lau J.S.Y.;Bhatt S.;Bryant M. | Monash Health Department(s): | Infectious Diseases and Clinical Microbiology | Institution: | (Lau, Korman, Woolley) Center for Inflammatory Diseases, Monash University, Clayton, Victoria 3168, Australia (Lau, Bhatt, Bryant, Korman, Woolley) Monash Infectious Diseases, Monash Health, Clayton, Victoria 3168, Australia (Streitberg, Korman) Monash Pathology, Monash Health, Clayton, Victoria 3168, Australia | Issue Date: | 30-Oct-2019 | Copyright year: | 2019 | Publisher: | Australasian College for Infection Prevention and Control | Place of publication: | Australia | Publication information: | Infection, Disease and Health. 24 (4) (pp 179-186), 2019. Date of Publication: November 2019. | Abstract: | Background: Some patients receive long-term or life-long antibiotics for suppression of infections deemed otherwise incurable. Little is known about the consequences of this strategy. We aimed to explore patients' attitudes towards and knowledge concerning prolonged antibiotic therapy. Method(s): A cross-sectional cohort pilot study of outpatients on long-term antibiotics was performed. Surveys were conducted at our healthcare network in Victoria, Australia between April and December 2015. Microbiological screening for multi-resistant organisms (MRO) was also performed. Result(s): Heterogeneity was noted in the prescribed antibiotics and documented indications, with rifampicin and fusidic acid for suppression of prosthetic joint infection the most common regimen and indication. 41% (12/29) of participants reported side-effects attributed to their antibiotics, but 72% (21/29) still declared complete adherence to their prescribed regimen. 76% (22/29) of participants stated that they would cease their long-term antibiotics based on medical advice. 19/29 (66%) participants consented to microbiological screening and 4 were found to be colonised with MROs. They had spent more days as an inpatient in the preceding 12 months than the screened participants who were not colonised. Conclusion(s): Participants in this study had a good understanding of their infection and the indications for their long-term antibiotic therapy, and were adherent to this therapy despite many experiencing side-effects attributed to their antibiotics. Patients who are prescribed life-long antibiotics can be carriers of multi-resistant organisms, but both the drivers of this resistance, and the broader impact of colonisation with MRO in this population is unclear.Copyright © 2019 | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.idh.2019.05.002 | PubMed URL: | 31229453 [http://www.ncbi.nlm.nih.gov/pubmed/?term=31229453] | ISSN: | 2468-0451 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/36029 | Type: | Article | Subjects: | clinical assessment *antibiotic agent/pv [Special Situation for Pharmacovigilance] cefalexin/pv [Special Situation for Pharmacovigilance] adult aged antibiotic therapy article bacterial colonization blood vessel graft body weight gain chronic osteomyelitis/dt [Drug Therapy] clinical article cohort analysis cross-sectional study diarrhea/si [Side Effect] drug indication *drug surveillance program *drug use female graft infection/dt [Drug Therapy] hospital patient human male medication compliance mycotic aneurysm/dt [Drug Therapy] nausea and vomiting/si [Side Effect] outpatient *patient attitude patient compliance pilot study prosthesis infection/dt [Drug Therapy] prosthetic valve endocarditis/dt [Drug Therapy] Staphylococcus aureus infection/dt [Drug Therapy] stomach discomfort/si [Side Effect] surgical infection/dt [Drug Therapy] thrush/si [Side Effect] urinary tract infection/dt [Drug Therapy] very elderly Victoria amoxicillin plus clavulanic acid/dt [Drug Therapy] amoxicillin plus clavulanic acid/pv [Special Situation for Pharmacovigilance] *antibiotic agent/ae [Adverse Drug Reaction] *antibiotic agent/dt [Drug Therapy] ciprofloxacin/pv [Special Situation for Pharmacovigilance] clindamycin/pv [Special Situation for Pharmacovigilance] cotrimoxazole/pv [Special Situation for Pharmacovigilance] doxycycline/pv [Special Situation for Pharmacovigilance] flucloxacillin/pv [Special Situation for Pharmacovigilance] fusidic acid/dt [Drug Therapy] fusidic acid/pv [Special Situation for Pharmacovigilance] nitrofurantoin/pv [Special Situation for Pharmacovigilance] penicillin derivative/pv [Special Situation for Pharmacovigilance] pristinamycin/dt [Drug Therapy] pristinamycin/pv [Special Situation for Pharmacovigilance] rifampicin/dt [Drug Therapy] rifampicin/pv [Special Situation for Pharmacovigilance] joint prosthesis clinical assessment cohort analysis cross-sectional study diarrhea / side effect drug indication *drug surveillance program *drug use female graft infection / drug therapy hospital patient human male medication compliance mycotic aneurysm / drug therapy nausea and vomiting / side effect outpatient *patient attitude patient compliance pilot study prosthesis infection / drug therapy prosthetic valve endocarditis / drug therapy stomach discomfort / side effect surgical infection / drug therapy thrush / side effect urinary tract infection / drug therapy very elderly Victoria Staphylococcus aureus infection / drug therapy adult aged antibiotic therapy Article bacterial colonization blood vessel graft body weight gain chronic osteomyelitis / drug therapy clinical article |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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