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Title: | Knowledge gaps and emerging research areas in intrauterine growth restriction-associated brain injury. | Authors: | Baud O.;Shearer I.K.;Walker D.W.;Tolcos M.;Gressens P.;Fleiss B.;Wong F. ;Brownfoot F. | Institution: | (Fleiss, Shearer, Walker, Tolcos) School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia (Fleiss, Baud, Gressens) NeuroDiderot, INSERM, Universite Paris Diderot, Sorbonne Paris Cite, Paris, France (Fleiss, Gressens) Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom (Wong) Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia (Wong) Department of Paediatrics, Monash University, Clayton, VIC, Australia (Wong) Monash Newborn, Monash Children's Hospital, Clayton, VIC, Australia (Brownfoot) Translational Obstetrics Group, Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, Heidelberg, VIC, Australia (Baud) Division of Neonatal Intensive Care, University Hospitals of Geneva, Children's Hospital, University of Geneva, Geneva, Switzerland (Gressens) PremUP, Paris, France | Issue Date: | 10-Jun-2019 | Copyright year: | 2019 | Publisher: | Frontiers Media S.A. (E-mail: info@frontiersin.org) | Place of publication: | Switzerland | Publication information: | Frontiers in Endocrinology. 10 (MAR) (no pagination), 2019. Article Number: 188. Date of Publication: 2019. | Journal: | Frontiers in Endocrinology | Abstract: | Intrauterine growth restriction (IUGR) is a complex global healthcare issue. Concerted research and clinical efforts have improved our knowledge of the neurodevelopmental sequelae of IUGR which has raised the profile of this complex problem. Nevertheless, there is still a lack of therapies to prevent the substantial rates of fetal demise or the constellation of permanent neurological deficits that arise from IUGR. The purpose of this article is to highlight the clinical and translational gaps in our knowledge that hamper our collective efforts to improve the neurological sequelae of IUGR. Also, we draw attention to cutting-edge tools and techniques that can provide novel insights into this disorder, and technologies that offer the potential for better drug design and delivery. We cover topics including: how we can improve our use of crib-side monitoring options, what we still need to know about inflammation in IUGR, the necessity for more human post-mortem studies, lessons from improved integrated histology-imaging analyses regarding the cell-specific nature of magnetic resonance imaging (MRI) signals, options to improve risk stratification with genomic analysis, and treatments mediated by nanoparticle delivery which are designed to modify specific cell functions.Copyright © 2019 Fleiss, Wong, Brownfoot, Shearer, Baud, Walker, Gressens and Tolcos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3389/fendo.2019.00188 | ISSN: | 1664-2392 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/36128 | Type: | Review | Subjects: | developmental disorder BOLD signal brain blood flow brain calcification brain histology *brain injury cardiovascular risk clinical trial (topic) conservative treatment diffusion weighted imaging *disease association disorders of higher cerebral function electroencephalography monitoring fetus outcome functional near-infrared spectroscopy functional neuroimaging genome analysis hemodynamic parameters human hypoxia immunomodulation immunopathology inflammation *intrauterine growth retardation low birth weight malnutrition metabolic disorder *nanomedicine nervous system inflammation neuromonitoring neuropathology nonhuman outcome assessment overnutrition perinatal asphyxia placenta disorder placenta insufficiency postnatal care pregnancy complication pregnancy diabetes mellitus prenatal care review single nucleotide polymorphism small for date infant stillbirth alpha fetoprotein/ec [Endogenous Compound] chorionic gonadotropin/ec [Endogenous Compound] creatine/ec [Endogenous Compound] gamma interferon/ec [Endogenous Compound] indoleamine 2,3 dioxygenase/ec [Endogenous Compound] inhibin A/ec [Endogenous Compound] interleukin 1beta/ec [Endogenous Compound] interleukin 6/ec [Endogenous Compound] leptin/ec [Endogenous Compound] monocyte chemotactic protein 1/ec [Endogenous Compound] nanoparticle placental growth factor/ec [Endogenous Compound] pregnancy associated plasma protein A/ec [Endogenous Compound] tumor necrosis factor/ec [Endogenous Compound] electroencephalograph nuclear magnetic resonance scanner brain sparing autoregulation biochemical analysis blood oxygenation pregnancy complication *brain injury autoregulation biochemical analysis blood oxygenation BOLD signal diffusion weighted imaging developmental disorder conservative treatment clinical trial (topic) cardiovascular risk brain blood flow brain calcification brain histology *disease association disorders of higher cerebral function electroencephalography monitoring fetus outcome functional near-infrared spectroscopy functional neuroimaging genome analysis hemodynamic parameters human hypoxia immunomodulation immunopathology inflammation *intrauterine growth retardation low birth weight malnutrition metabolic disorder *nanomedicine nervous system inflammation neuromonitoring neuropathology nonhuman outcome assessment overnutrition perinatal asphyxia placenta disorder placenta insufficiency postnatal care pregnancy diabetes mellitus prenatal care Review single nucleotide polymorphism small for date infant stillbirth |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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