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Conference/Presentation Title: | Evaluation of cardiovascular function in women with a history of pre-eclampsia: A systematic review and meta-analysis. | Authors: | Gerche A.L.;Mol B. ;Costa F.;Palmer K. ;Wallace E.;Reddy M. ;Wright L.;Rolnik D.;Li W. | Monash Health Department(s): | Obstetrics and Gynaecology (Monash Women's) | Institution: | (Reddy, Rolnik, Li, Mol, Costa, Wallace, Palmer) Department of Obstetrics and Gynaecology, Monash University (Reddy, Rolnik, Palmer) Monash Women's, Monash Health (Wright, Gerche) Baker Heart and Diabetes Institute (Gerche) Department of Cardiology, St Vincent's Hospital (Costa) Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo | Presentation/Conference Date: | 29-Apr-2020 | Copyright year: | 2019 | Publisher: | Blackwell Publishing | Publication information: | Australian and New Zealand Journal of Obstetrics and Gynaecology. Conference: Annual Scientifi c Meeting of the Royal Australian and New Zealand College of Obstetricians and Gynaecologists, RANZCOG 2019. Melbourne, VIC Australia. 59 (Supplement 1) (pp 39), 2019. Date of Publication: October 2019. | Journal: | Australian and New Zealand Journal of Obstetrics and Gynaecology | Abstract: | Introduction: Women with a history of pre-eclampsia are at increased risk of lifelong cardiovascular morbidity and mortality. However, the underlying mechanisms of disease association, and the ideal method of monitoring this high-risk group remains unclear. The aim of this study is to determine whether women with a history of pre-eclampsia show clinical or subclinical cardiovascular changes when evaluated by echocardiography. Method(s): A systematic search of MEDLINE, EMBASE and CINAHL databases was performed to identify studies that examined cardiovascular function in women with a history of pre-eclampsia, in comparison to those with a history of normotensive pregnancies. Result(s): In the 27 included studies, there was significant heterogeneity in the outcome measures and varying quality between studies. We found no statistically significant differences between exposed and non-exposed women with regard to left ventricular ejection fraction, isovolumetric relaxation time or deceleration time. Women with a history of pre-eclampsia demonstrated a higher left ventricular mass index and relative wall thickness with a mean difference of 4.25 g/m2 (95%CI 2.08,6.42) and 0.03 (95%CI 0.01, 0.05), respectively. In comparison to the non-exposed population they also demonstrated a lower E/A and a higher E/e' ratio with a mean difference of-0.08 (95%CI-0.15,-0.01) and 0.84 (95%CI 0.41, 1.27), respectively. Discussion(s): In comparison to women with a normotensive pregnancy, women with a history of pre-eclampsia demonstrate a trend towards altered cardiac structure and function. Further studies with larger sample sizes, and consistent echocardiograph reporting are required to assess the role of echocardiography in monitoring this high-risk group. | Conference Start Date: | 2019-10-13 | Conference End Date: | 2019-10-16 | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/ajo.13067 | ISSN: | 1479-828X | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/36419 | Type: | Conference Abstract | Subjects: | deceleration echocardiograph echocardiography Embase female *heart left ventricle ejection fraction heart left ventricle mass heart ventricle remodeling high risk population human Medline outcome assessment adult pregnancy relaxation time risk assessment sample size structure activity relation systematic review thickness Cinahl *preeclampsia conference abstract controlled study deceleration echocardiograph echocardiography heart left ventricle ejection fraction heart left ventricle mass heart ventricle reing high risk pregnancy relaxation time structure activity relation thickness preeclampsia human Medline outcome assessment *preeclampsia pregnancy relaxation time risk assessment sample size structure activity relation systematic review thickness female echocardiography echocardiograph deceleration controlled study conference abstract Embase *heart left ventricle ejection fraction heart left ventricle mass heart ventricle remodeling high risk population Cinahl adult |
Type of Clinical Study or Trial: | Systematic review and/or meta-analysis |
Appears in Collections: | Conferences |
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