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Conference/Presentation Title: | In vitro maturation (IVM) versus in vitro fertilization (IVF) in women with high antral follicle count (AFC): a randomized controlled trial (NCT03405701). | Authors: | Vuong L.N.;Wang R.;Norman R.J.;Gilchrist R.B.;Smitz J.;Mol B.W. ;Le A.H.;Pham T.D.;Giang N.H.;Phung T.H.;Dang V.Q.;Ho T.M.;Ho V.N.A. | Institution: | (Vuong) University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh, Vietnam (Ho, Ho, Dang, Phung, Giang, Le, Pham) HOPE Research Center, Ho Chi Minh, Vietnam (Wang, Norman) The University of Adelaide, Robinson Research Institute, Adelaide, SA, Australia (Gilchrist) School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, Australia (Smitz) Follicle Biology Laboratory, Vrije Universiteit Brussel, Brussels, Belgium (Mol) Monash University, Monash Medical Centre, Department of Obstetrics and Gynaecology, Melbourne, VIC, Australia | Presentation/Conference Date: | 19-Sep-2019 | Copyright year: | 2019 | Publisher: | Elsevier Inc. | Publication information: | Fertility and Sterility. Conference: 75th Scientific Congress of the American Society for Reproductive Medicine. Philadelphia United States. 112 (3 Supplement) (pp e435-e436), 2019. Date of Publication: September 2019. | Abstract: | Objective: IVM has been proposed as an alternative to IVF for women at increased risk of ovarian hyperstimulation syndrome (OHSS) due to a high antral follicle count (AFC) and/or polycystic ovary syndrome (PCOS). Here, we compare the effectiveness and safety of one IVM and one IVF cycle in women with infertility and high AFC. Design(s): A single-center noninferiority randomized controlled trial (NCT03405701) in Vietnam. Material(s) and Method(s): Women scheduled for assisted reproductive technology (ART) with an AFC>=24 were randomized (1:1 ratio) to IVM or IVF. In the IVM group, oocyte pick-up was performed 42 hours after the last injection of highly purified human menopausal gonadotropin (hp-hMG) 150 IU/day; all oocytes were cultured in capacitation pre-maturation medium for 24 h and then transferred to maturation culture for 30 h. Women allocated to IVF underwent ovarian stimulation using a hp-hMG/gonadotropin releasing hormone (GnRH) antagonist protocol and oocytes were retrieved 36 h after GnRH agonist trigger. In both groups, mature oocytes were fertilized using intracytoplasmic sperm injection, and all embryos were frozen on day 3; <=2 embryos were transferred in a subsequent frozen cycle. The primary outcome was live birth after first embryo transfer of the started treatment cycle. The planned sample size was 546, assuming an expected live birth rate of 45% in the IVF group, a noninferiority margin of -10%, 90% power and 15% loss to follow-up. While follow-up for live birth is ongoing, we report ongoing pregnancy in this abstract. Result(s): Between January 2018 and December 2018, we randomized 546 women (273 in each group). Baseline characteristics were comparable (mean age 30 years, BMI 22 kg/m2). The ongoing pregnancy rates after the first embryo transfer were 38% and 46%, respectively (difference -8.1% [-16.7%, 0.6%]). Other fertility outcomes after first embryo transfer were also not statistically significant between the groups (Table). All laboratory outcomes favoured IVF over IVM: oocytes retrieved (19.8 vs 14.1), MII oocytes (15.7 vs 8.9), maturation rate (79% vs 64%), fertilized oocytes (13.7 vs 7.3), top-quality embryos (7.9 vs 3.2), and freezable embryos (7.6 vs 4.0) were significantly higher in the IVF vs IVM group (all p<0.001). Conclusion(s): Among women undergoing ART with an AFC>=24, IVM did not result in significantly lower ongoing pregnancy rates than IVF. Live birth data will be available by October 2019. [Figure presented]Copyright © 2019 | Conference Start Date: | 2019-10-12 | Conference End Date: | 2019-10-16 | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.fertnstert.2019.08.015 | ISSN: | 0015-0282 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/36542 | Type: | Conference Abstract | Subjects: | Viet Nam endogenous compound gonadorelin gonadorelin agonist gonadorelin antagonist human menopausal gonadotropin conference abstract comparative effectiveness adult *antral follicle count body mass controlled study drug safety embryo *embryo transfer female follow up human human cell *in vitro fertilization infertility therapy intracytoplasmic sperm injection live birth major clinical study oocyte outcome assessment ovary hyperstimulation ovary polycystic disease ovulation induction pregnancy rate randomized controlled trial sample size spermatozoon capacitation infertility therapy intracytoplasmic sperm injection live birth major clinical study oocyte outcome assessment ovary hyperstimulation ovary polycystic disease ovulation induction pregnancy rate randomized controlled trial sample size spermatozoon capacitation Viet Nam controlled study comparative effectiveness body mass *antral follicle count adult drug safety embryo *embryo transfer female follow up human human cell *in vitro fertilization |
Type of Clinical Study or Trial: | Randomised controlled trial |
Appears in Collections: | Conferences |
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