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https://repository.monashhealth.org/monashhealthjspui/handle/1/36922| Title: | Anti-CD20 monoclonal antibodies: reviewing a revolution. | Authors: | Opat S. ;Casan J.M.L.;Wong J.;Northcott M.J. | Institution: | (Casan, Wong, Opat) Haematology Department, Monash Health, Melbourne, Australia (Northcott) Rheumatology Department, Monash Health, Melbourne, Australia (Northcott, Opat) School of Clinical Sciences, Monash University, Melbourne, Australia | Issue Date: | 22-Jun-2019 | Copyright year: | 2018 | Publisher: | Taylor and Francis Inc. (325 Chestnut St, Suite 800, Philadelphia PA 19106, United States) | Place of publication: | United States | Publication information: | Human Vaccines and Immunotherapeutics. 14 (12) (pp 2820-2841), 2018. Date of Publication: 02 Dec 2018. | Journal: | Human Vaccines and Immunotherapeutics | Abstract: | Since the inception of rituximab in the 1990s, anti-CD20 monoclonal antibodies have revolutionised the treatment of B cell hematological malignancies and have become a cornerstone of modern gold-standard practice. Additionally, the potent efficacy of these agents in depleting the B cell compartment has been used in the management of a broad array of autoimmune diseases. Multiple iterations of these agents have been investigated and are routinely used in clinical practice. In this review, we will discuss the physiology of CD20 and its attractiveness as a therapeutic target, as well as the pharmacology, pre-clinical and clinical data for the major anti-CD20 monoclonal antibodies: rituximab, obinutuzumab and ofatumumab.Copyright © 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1080/21645515.2018.1508624 | PubMed URL: | 30096012 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30096012] | ISSN: | 2164-5515 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/36922 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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