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https://repository.monashhealth.org/monashhealthjspui/handle/1/37224| Title: | TGF-beta: Master regulator of inflammation and fibrosis. | Authors: | Koff J.;Stewart A.G.;Thomas B. | Institution: | (Stewart) Department of Pharmacology and Therapeutics, The University of Melbourne, Melbourne, VIC, Australia (Stewart) Lung Health Research Centre, The University of Melbourne, Melbourne, VIC, Australia (Stewart) ARC Centre for Personalized Therapeutics Technologies, Australia (Thomas) Monash Lung and Sleep, Monash Medical Centre, Melbourne, VIC, Australia (Thomas) Department of Medicine, Monash University, Melbourne, VIC, Australia (Thomas) Department of Molecular and Translational Sciences, Monash University, Melbourne, VIC, Australia (Thomas) Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Melbourne, VIC, Australia (Koff) Pulmonary, Critical Care and Sleep Medicine, Yale University, New Haven, CT, United States | Issue Date: | 27-Nov-2018 | Copyright year: | 2018 | Publisher: | Blackwell Publishing | Place of publication: | Australia | Publication information: | Respirology. 23 (12) (pp 1096-1097), 2018. Date of Publication: December 2018. | Journal: | Respirology | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/resp.13415 | ORCID: | Stewart, Alastair G.; ORCID: http://orcid.org/0000-0002-2271-5942 | Link to associated publication: | Click here for full text options | PubMed URL: | 30284753 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30284753] | ISSN: | 1323-7799 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/37224 | Type: | Note | Subjects: | gene targeting human *inflammation inhibition kinetics mesenchyme cell negative feedback note positive feedback priority journal promoter region protein phosphorylation regulatory T lymphocyte respiratory tract disease/dt [Drug Therapy] TGF beta signaling cyclic AMP/ec [Endogenous Compound] cyclic AMP dependent protein kinase/ec [Endogenous Compound] cystic fibrosis transmembrane conductance regulator/ec [Endogenous Compound] glucocorticoid/dt [Drug Therapy] glucocorticoid/pd [Pharmacology] microRNA 145/ec [Endogenous Compound] mitogen activated protein kinase/ec [Endogenous Compound] prostaglandin E2 protein serine threonine kinase inhibitor/pd [Pharmacology] Smad2 protein/ec [Endogenous Compound] Smad3 protein/ec [Endogenous Compound] Smad4 protein/ec [Endogenous Compound] *transforming growth factor beta/ec [Endogenous Compound] transforming growth factor beta receptor 1/ec [Endogenous Compound] TGF beta gene signal transduction asthma/et [Etiology] chronic obstructive lung disease/et [Etiology] *cystic fibrosis disease exacerbation disease severity DNA polymorphism DNA responsive element enzyme activation epithelial mesenchymal transition extracellular matrix fibrogenesis fibrosing alveolitis gene expression regulation gene expression regulation gene targeting human *inflammation inhibition kinetics mesenchyme cell negative feedback Note positive feedback priority journal promoter region protein phosphorylation disease exacerbation respiratory tract disease / drug therapy signal transduction TGF beta signaling *cystic fibrosis chronic obstructive lung disease / etiology asthma / etiology regulatory T lymphocyte disease severity DNA polymorphism DNA responsive element enzyme activation epithelial mesenchymal transition extracellular matrix fibrogenesis fibrosing alveolitis |
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