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DC Field | Value | Language |
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dc.contributor.author | Segelov E. | en |
dc.contributor.author | Waring P.M. | en |
dc.contributor.author | Tejpar S. | en |
dc.contributor.author | Khasraw M. | en |
dc.contributor.author | Van Hazel G.A. | en |
dc.contributor.author | Simes J. | en |
dc.contributor.author | Gebski V.J. | en |
dc.contributor.author | Desai J. | en |
dc.contributor.author | Shapiro J.D. | en |
dc.contributor.author | Thavaneswaran S. | en |
dc.contributor.author | Underhill C.R. | en |
dc.contributor.author | Robledo K.P. | en |
dc.contributor.author | Karapetis C.S. | en |
dc.contributor.author | Day F.L. | en |
dc.contributor.author | Nott L.M. | en |
dc.contributor.author | Jefford M. | en |
dc.contributor.author | Chantrill L.A. | en |
dc.contributor.author | Pavlakis N. | en |
dc.contributor.author | Tebbutt N.C. | en |
dc.contributor.author | Price T.J. | en |
dc.date.accessioned | 2021-05-14T12:39:39Z | en |
dc.date.available | 2021-05-14T12:39:39Z | en |
dc.date.copyright | 2018 | en |
dc.date.created | 20181128 | en |
dc.date.issued | 2018-11-28 | en |
dc.identifier.citation | Clinical Colorectal Cancer. 17 (4) (pp 313-319), 2018. Date of Publication: December 2018. | en |
dc.identifier.issn | 1533-0028 | en |
dc.identifier.uri | https://repository.monashhealth.org/monashhealthjspui/handle/1/37234 | en |
dc.description.abstract | Most unresectable metastatic colon cancer remains incurable, with a median survival of less than 3 years. Molecularly targeted therapies have recently been developed; in particular, monoclonal antibodies against the epidermal growth factor receptor, which are efficacious in 40% to 60% of chemotherapy-resistant patients with wild-type KRAS. This study shows that cetuximab plus irinotecan, compared with cetuximab alone, increases the response rate and delays progression in irinotecan-resistant RAS wild-type colorectal cancer. Background(s): The Irinotecan Cetuximab Evaluation and Cetuximab Response Evaluation (ICECREAM) study assessed the efficacy of cetuximab monotherapy compared with cetuximab combined with chemotherapy for quadruple wild-type (KRAS, NRAS, BRAF, or P13KCA exon 20) metastatic colorectal cancer. Patients and Methods: Patients were enrolled in an open-label, multicenter, phase II trial and randomly assigned to cetuximab 400 mg/m2, then 250 mg/m2 cetuximab weekly, with or without irinotecan 180 mg/m2 every 2 weeks. The primary endpoint was 6-month progression-free survival; secondary endpoints were response rate, overall survival, toxicity, and quality of life. Result(s): From 2012 to 2016, 48 patients were recruited. Two were ineligible, and 2 were not evaluable for response. Characteristics were balanced, except gender (male, 62% vs. 72%) and primary sidedness (left, 95% vs. 68%). For cetuximab compared with cetuximab-irinotecan, progression-free survival was 14% versus 41% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P =.008); response rate was 10% (2 partial responses) versus 38% (1 complete, 8 partial); P =.04. Grade 3 to 4 toxicities were less with cetuximab monotherapy (23% vs. 50%); global and specific quality of life scores did not differ. Conclusion(s): In comparison with cetuximab alone, cetuximab plus irinotecan increases the response rate and delays progression in irinotecan-resistant RAS wild-type colorectal cancer. This echoes data from molecularly unselected patients.Copyright © 2018 | en |
dc.language | English | en |
dc.language | en | en |
dc.publisher | Elsevier Inc. (E-mail: usjcs@elsevier.com) | en |
dc.relation.ispartof | Clinical Colorectal Cancer | en |
dc.title | Cetuximab Alone or With Irinotecan for Resistant KRAS-, NRAS-, BRAF- and PIK3CA-wild-type Metastatic Colorectal Cancer: The AGITG Randomized Phase II ICECREAM Study. | en |
dc.type | Article | en |
dc.identifier.affiliation | Oncology | - |
dc.type.studyortrial | Randomised controlled trial | - |
dc.identifier.doi | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.clcc.2018.06.002 | en |
dc.publisher.place | United States | en |
dc.identifier.orcid | Jefford, Michael; ORCID: http://orcid.org/0000-0002-8792-7807 Price, Timothy. J.; ORCID: http://orcid.org/0000-0002-3922-2693 | en |
dc.identifier.pubmedid | 30463680 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30463680] | en |
dc.identifier.source | 2000893879 | en |
dc.identifier.institution | (Shapiro) Cabrini Haematology and Oncology Centre, Cabrini Hospital and Monash University, Malvern, Victoria, Australia (Thavaneswaran, Robledo, Khasraw, Simes, Gebski) National Health and Medical Research Council Clinical Trials Centre, University of Sydney, Camperdown, New South Wales, Australia (Underhill) Albury-Wodonga Regional Cancer Centre and University of New South Wales, East Albury, New South Wales, Australia (Karapetis) Department of Medical Oncology, Flinders Medical Centre and Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, South Australia, Australia (Day) Department of Medical Oncology, Calvary Mater Newcastle Hospital and University of Newcastle, Waratah, New South Wales, Australia (Nott) Department of Medical Oncology, Royal Hobart Hospital, Hobart, Tasmania, Australia (Jefford) Department of Medical Oncology, Peter MacCallum Cancer Centre, Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia (Chantrill) Department of Medical Oncology, Kinghorn Cancer Centre, St Vincent's Hospital and University of New South Wales, Darlinghurst, New South Wales, Australia (Pavlakis) Northern Cancer Institute, Royal North Shore Hospital, University of Sydney, St Leonards, New South Wales, Australia (Tebbutt) Department of Medical Oncology, Austin Health, Heidelberg, Victoria, Australia (Price) Medical Oncology Unit, Queen Elizabeth Hospital and Lyell McEwin Hospital, Elizabeth Vale, South Australia, Australia (Khasraw) Department of Medical Oncology, Geelong Hospital, Geelong, Victoria, Australia (Van Hazel) School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia (Waring) Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia (Tejpar) Oncology Department, University Hospital Leuven, Leuven, Belgium (Desai) Department of Medical Oncology, Royal Melbourne Hospital and Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia (Segelov) Department of Oncology, Monash Health and Monash University, Clayton, Victoria, Australia | en |
dc.description.address | J.D. Shapiro, Associate Professor of Medicine, Monash University, Cabrini Haematology and Oncology Centre, 183 Wattletree Rd, Malvern, Vic 3144, Australia. E-mail: jeremy.shapiro@monash.edu | en |
dc.description.publicationstatus | Embase | en |
dc.rights.statement | Copyright 2018 Elsevier B.V., All rights reserved. | en |
dc.subect.keywords | Cetuximab Chemotherapy colon cancer Irinotecan RAS | en |
dc.identifier.authoremail | Shapiro J.D.; jeremy.shapiro@monash.edu | en |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
crisitem.author.dept | Oncology | - |
Appears in Collections: | Articles |
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