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Title: | High-molecular-weight adiponectin is inversely associated with sympathetic activity in polycystic ovary syndrome. | Authors: | Abell S.K.;Hiam D.S.;Lambert E.A.;Eikelis N.;Jona E.;Sari C.I.;Stepto N.K.;Lambert G.W.;de Courten B. ;Teede H.J. ;Shorakae S. | Institution: | (Shorakae, Abell, Jona, Stepto, de Courten, Teede) Monash Centre for Health Research and Implementation, Monash University, Clayton, Victoria, Australia (Shorakae, Abell, de Courten, Teede) Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Victoria, Australia (Hiam, Stepto) Institute of Sport Exercise and Active Living (ISEAL), Victoria University, Melbourne, Victoria, Australia (Lambert, Eikelis, Lambert) Iverson Health Innovation Research Institute, Faculty of Health, Arts and Design, Swinburne University of Technology, Melbourne, Victoria, Australia (Lambert) Department of Physiology, Monash University, Melbourne, Victoria, Australia (Eikelis, Sari, Lambert) Human Neurotransmitters Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia | Issue Date: | 31-Mar-2018 | Copyright year: | 2018 | Publisher: | Elsevier Inc. (E-mail: usjcs@elsevier.com) | Place of publication: | United States | Publication information: | Fertility and Sterility. 109 (3) (pp 532-539), 2018. Date of Publication: March 2018. | Journal: | Fertility and Sterility | Abstract: | Objective: To examine the role of high-molecular-weight (HMW) adiponectin and its relationship to sympathetic activity in women with polycystic ovary syndrome (PCOS). Design(s): Cross sectional study using biobanked samples. Setting(s): Not applicable. Patient(s): Premenopausal women with PCOS (n = 46, Rotterdam diagnostic criteria) and without PCOS (n = 22). Intervention(s): None. Main Outcome Measure(s): High-molecular-weight adiponectin levels with secondary outcomes of sympathetic activity and leptin levels. Result(s): The high-molecular-weight adiponectin level was lower in women with PCOS (median 2.2 [interquartile range (IQR)2.3] mug/mL) than in controls (median 3 [IQR2.5] mug/mL) (age and BMI adjusted), and it correlated inversely with the values measured for homeostatic model of assessment of insulin resistance (HOMA-IR), fasting insulin, triglycerides, and free androgen index and positively with sex hormone-binding globulin (SHBG) and high-density lipoprotein cholesterol in all participants and in the PCOS group. In the PCOS group, sympathetic activity (burst frequency) was statistically significantly higher than in controls (median 26 [IQR11] vs. median 22 [IQR14], respectively) and correlated inversely with HMW adiponectin (r = -0.230). The leptin levels were similar between the women with PCOS and controls and did not statistically significantly correlate with HMW adiponectin or sympathetic activity. On multiple regression analysis, burst frequency and SHBG explained 40% of the HMW adiponectin variability (B = -0.7; 95% CI -1.2 to -0.2; and B = 0.01; 95% CI 0.004-0.01) in PCOS. Conclusion(s): Alongside insulin resistance, increased sympathetic activity is associated with and may modulate HMW adiponectin levels in women with PCOS.Copyright © 2017 American Society for Reproductive Medicine | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.fertnstert.2017.11.020 | Link to associated publication: | Click here for full text options | PubMed URL: | 29428305 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29428305] | ISSN: | 0015-0282 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/37382 | Type: | Article | Subjects: | insulin/ec [Endogenous Compound] leptin/ec [Endogenous Compound] triacylglycerol/ec [Endogenous Compound] sex hormone binding globulin/ec [Endogenous Compound] adult anthropometry article clinical article controlled study cross-sectional study female homeostasis model assessment human insulin resistance metabolic syndrome X molecular weight muscle sympathetic nerve activity observational study *ovary polycystic disease premenopause priority journal randomized controlled trial (topic) *sympathetic tone adipocytokine *adiponectin/ec [Endogenous Compound] androgen/ec [Endogenous Compound] high density lipoprotein cholesterol/ec [Endogenous Compound] insulin resistance metabolic syndrome X molecular weight muscle sympathetic nerve activity observational study *ovary polycystic disease female cross-sectional study controlled study clinical article Article anthropometry adult homeostasis model assessment human *sympathetic tone randomized controlled trial (topic) priority journal premenopause |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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