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https://repository.monashhealth.org/monashhealthjspui/handle/1/37605| Title: | Treatment of preeclampsia with hydroxychloroquine: a review. | Authors: | Abd Rahman R.;DeKoninck P.;Murthi P.;Wallace E.M. | Monash Health Department(s): | Obstetrics and Gynaecology (Monash Women's) | Institution: | (Abd Rahman) Department of Obstetrics and Gynecology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia (DeKoninck, Murthi, Wallace) Department of Medicine, School of Clinical Sciences, Monash University, Monash Medical Centre, Clayton, VIC, Australia (Abd Rahman, Wallace) The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC, Australia | Issue Date: | 5-Feb-2018 | Copyright year: | 2018 | Publisher: | Taylor and Francis Ltd (E-mail: healthcare.enquiries@informa.com) | Place of publication: | United Kingdom | Publication information: | Journal of Maternal-Fetal and Neonatal Medicine. 31 (4) (pp 525-529), 2018. Date of Publication: 16 Feb 2018. | Journal: | Journal of Maternal-Fetal and Neonatal Medicine | Abstract: | In this review, we discuss the potential use of antimalarial drugs as an adjuvant therapy for preeclampsia, focusing on the mechanisms of action of this class of drugs in the context of preeclampsia. In particular, hydroxychloroquine has been shown to have various beneficial effects on patients with systemic lupus erythematosus. There are several pathways targeted by the antimalarial drugs that are similar to the pathophysiology of preeclampsia and hence offering opportunities to develop novel therapies to treat the disease. Given the safety profile of hydroxychloroquine in pregnancy, there is merit in exploring the efficacy of this drug as an adjuvant therapy in women with early onset preeclampsia.Copyright © 2017 Informa UK Limited, trading as Taylor & Francis Group. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1080/14767058.2017.1289511 | ORCID: | Murthi, Padma; ORCID: http://orcid.org/0000-0003-2535-5134 Wallace, Euan M.; ORCID: http://orcid.org/0000-0002-4506-5233 | Link to associated publication: | Click here for full text options | PubMed URL: | 28142291 [http://www.ncbi.nlm.nih.gov/pubmed/?term=28142291] | ISSN: | 1476-7058 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/37605 | Type: | Review | Subjects: | preeclampsia/dt [Drug Therapy] priority journal pruritus/si [Side Effect] review *hydroxychloroquine/ae [Adverse Drug Reaction] *hydroxychloroquine/dt [Drug Therapy] *hydroxychloroquine/pd [Pharmacology] reduced nicotinamide adenine dinucleotide phosphate oxidase/ec [Endogenous Compound] toll like receptor 3/ec [Endogenous Compound] toll like receptor 7/ec [Endogenous Compound] toll like receptor 9/ec [Endogenous Compound] vascular protective effect drug safety *adjuvant therapy antiinflammatory activity antioxidant activity cell protection drug effect drug efficacy drug mechanism drug targeting enzyme activity gastrointestinal symptom/si [Side Effect] headache/si [Side Effect] human nonhuman oxidative stress pathophysiology *preeclampsia/dt [Drug Therapy] oxidative stress pathophysiology *preeclampsia / *drug therapy preeclampsia / drug therapy priority journal pruritus / side effect Review cell protection drug effect antiinflammatory activity *adjuvant therapy antioxidant activity drug efficacy drug mechanism drug safety drug targeting enzyme activity gastrointestinal symptom / side effect headache / side effect human nonhuman |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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