Mortality following cardiovascular and bleeding events occurring beyond 1 year after coronary stenting: A secondary analysis of the Dual Antiplatelet Therapy (DAPT) Study.

Hopkins J.; McGarry T.; Nygaard T.; Pow T.; Larkin T.; Caulfield T.; Stys T.; Lee T.; Mansouri V.; Srinivas V.; Gupta V.; Marquardt W.; Ballard W.; Bachinsky W.; Colyer W.; Dillon W.; Felten W.; French W.; Kuehl W.; Nicholas W.; Nicholson W.; Phillips W.; Khatib Y.; Al-Saghir Y.; Hawa Z.; Masud Z.; Jafar Z.; Muller D.; Meredith I.; Rankin J.; Worthley M.; Jepson N.; Thompson P.; Hendriks R.; Whitbourn R.; Duffy S.; Stasek J.; Novobilsky K.; Naplava R.; Coufal Z.; Vaquette B.; Bressollette E.; Teiger E.; Coste P.; Rihani R.; Darius H.; Bergmann M.W.; Radke P.; Sebastian P.; Strasser R.; Hoffmann S.; Behrens S.; Moebius-Winkler S.; Rutsch W.; Lupkovics G.; Horvath I.; Kancz S.; Forster T.; Koszegi Z.; Devlin G.; Hart H.; Elliott J.; Ormiston J.; Abernathy M.; Fisher N.; Kay P.; Harding S.; Jaffe W.; Hoffmann A.; Sosnowski C.; Trebacz J.; Buszman P.; Dobrzycki S.; Kornacewicz-Jach Z.; Iancu A.C.; Ginghina C.D.; Matei C.; Dobreanu D.; Bolohan F.R.; Dorobantu M.; Jacques A.; Jain A.; Bakhai A.; Gershlick A.; Adamson D.; Newby D.; Felmeden D.; Purcell I.; Edmond J.; Irving J.; De Belder M.; Pitt M.; Kelly P.; O'Kane P.; Clifford P.; Suresh V.; Secemsky E.A.; Yeh R.W.; Kereiakes D.J.; Cutlip D.E.; Cohen D.J.; Steg P.G.; Cannon C.P.; Apruzzese P.K.; D'Agostino R.B.; Massaro J.M.; Mauri L.; Kaplan A.; Ahmed A.; Ahmed A.-H.; Albirini A.; Moreyra A.; Rabinowitz A.; Shroff A.; Moak A.; Jacobs A.; Kabour A.; Gupta A.; Irimpen A.; Rosenthal A.; Taussig A.; Ferraro A.; Chhabra A.; Pucillo A.; Spaedy A.; White A.; Pratsos A.; Shakir A.; Ghitis A.; Agarwal A.; Chawla A.; Tang A.; Barker B.; Bertolet B.; Uretsky B.; Erickson B.; Rama B.; McLaurin B.; Dearing B.; Negus B.; Price B.; Brott B.; Bhambi B.; Bowers B.; Watt B.; Donohue B.; Hassel C.D.; Croft C.; Lambert C.; O'Shaughnessy C.; Shoultz C.; Kim C.; Caputo C.; Nielson C.; Scott C.; Wolfe C.; McKenzie C.; Brachfeld C.; Thieling C.; Fisher D.; Simon D.; Churchill D.; Dobies D.; Eich D.; Goldberg D.; Griffin D.; Henderson D.; Kandzari D.; Lee D.; Lewis D.; Mego D.; Paniagua D.; Rizik D.; Roberts D.; Safley D.; Abbott D.; Shaw D.; Temizer D.; Canaday D.; Myears D.; Westerhausen D.; Ebersole D.; Netz D.; Baldwin D.; Letts D.; Harlamert E.; Kosinski E.; Portnay E.; Mahmud E.; Korban E.; Hockstad E.; Rivera E.; Shawl F.; Shamoon F.; Kiernan F.; Aycock G.R.; Schaer G.; Kunz G.; Kichura G.; Myers G.; Pilcher G.; Tadros G.; Kaddissi G.I.; Ramadurai G.; Eaton G.; Elsner G.; Mishkel G.; Simonian G.; Piegari G.; Chen H.; Liberman H.; Aronow H.; Tamboli H.P.; Dotani I.; Marin J.; Fleischhauer J.F.; Leggett J.; Mills J.; Phillips J.; Revenaugh J.; Mann J.T.; Wilson J.; Pattanayak J.; Aji J.; Strain J.; Patel J.; Carr J.; Moses J.; Chen J.-C.; Williams J.; Greenberg J.; Cohn J.; Douglas J.; Gordon J.; Griffin J.; Hawkins J.; Katopodis J.; Lopez J.; Marshall J.; Wang J.; Waltman J.; Saucedo J.; Galichia J.; McClure M.; Kozina J.; Stella J.; Tuma J.; Kieval J.; Giri K.; Ramanathan K.; Allen K.; Atassi K.; Baran K.; Khaw K.; Clayton K.; Croce K.; Skelding K.; Patel K.; Garratt K.; Harjai K.; Chandrasekhar K.; Kalapatapu K.; Lin L.; Dean L.; Barr L.; MacDonald L.; Cannon L.; Satler L.; Gruberg L.; Tami L.; Bikkina M.; Shah M.; Atieh M.; Chauhan M.; Litt M.; Unterman M.; Lechin M.; Zughaib M.; Fisch M.; Grabarczyk M.; Greenberg M.; Lurie M.; Rothenberg M.; Stewart M.; Purvis M.; Hook M.; Leesar M.; Buchbinder M.; Weiss M.; Guerrero M.; Abu-Fadel M.; Ball M.; Chang M.; Cunningham M.; Del Core M.; Jones M.; Kelberman M.; Lim M.; Ragosta M.; Rinaldi M.; Rosenberg M.; Savage M.; Tamberella M.; Kellett M.; Vidovich M.; Effat M.; Mirza M.A.; Khan M.; Dib N.; Laufer N.; Kleiman N.; Farhat N.; Amjadi N.; Schechtmann N.; Bladuell N.; Quintana O.; Gigliotti O.; Best P.; Flaherty P.; Hall P.; Gordon P.; Gurbel P.; Ho P.; Luetmer P.; Mahoney P.; Mullen P.; Teirstein P.; Tolerico P.; Ramanathan P.; Kerwin P.; Lee P.V.; Kraft P.; Wyman R.M.; Gonzalez R.; Kamineni R.; Dave R.; Sharma R.; Prashad R.; Aycock R.; Quesada R.; Goodroe R.; Magorien R.; Randolph R.; Bach R.; Kettelkamp R.; Paulus R.; Waters R.; Zelman R.; Ganim R.; Bashir R.; Applegate R.; Feldman R.; Frankel R.; Hibbard R.; Jobe R.; Jumper R.; Maholic R.; Siegel R.; Smith R.; Stoler R.; Watson R.; Wheatley R.; Gammon R.; Hill R.; Sundrani R.; Caputo R.; Jenkins R.; Stella R.; Germanwala S.; Hadeed S.; Ledford S.; Dube S.; Gupta S.; Davis S.; Martin S.; Waxman S.; Dixon S.; Naidu S.; Potluri S.; Cook S.; Crowley S.; Kirkland S.; McIntyre S.; Thew S.; Lin S.; Marshalko S.; Guidera S.; Hearne S.; Karas S.; Manoukian S.; Rowe S.; Yakubov S.; Pollock S.; Banerjee S.; Allaqaband S.; Choi S.; Mulukutla S.; Papadakos S.; Bajwa T.; Addo T.; Schreiber T.; Haldis T.; Mathew T.

Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/38257

Title:	Mortality following cardiovascular and bleeding events occurring beyond 1 year after coronary stenting: A secondary analysis of the Dual Antiplatelet Therapy (DAPT) Study.
Authors:	Hopkins J.;McGarry T.;Nygaard T.;Pow T.;Larkin T.;Caulfield T.;Stys T.;Lee T.;Mansouri V.;Srinivas V.;Gupta V.;Marquardt W.;Ballard W.;Bachinsky W.;Colyer W.;Dillon W.;Felten W.;French W.;Kuehl W.;Nicholas W.;Nicholson W.;Phillips W.;Khatib Y.;Al-Saghir Y.;Hawa Z.;Masud Z.;Jafar Z.;Muller D.;Meredith I. ;Rankin J.;Worthley M.;Jepson N.;Thompson P.;Hendriks R.;Whitbourn R.;Duffy S.;Stasek J.;Novobilsky K.;Naplava R.;Coufal Z.;Vaquette B.;Bressollette E.;Teiger E.;Coste P.;Rihani R.;Darius H.;Bergmann M.W.;Radke P.;Sebastian P.;Strasser R.;Hoffmann S.;Behrens S.;Moebius-Winkler S.;Rutsch W.;Lupkovics G.;Horvath I.;Kancz S.;Forster T.;Koszegi Z.;Devlin G.;Hart H.;Elliott J.;Ormiston J.;Abernathy M.;Fisher N.;Kay P.;Harding S.;Jaffe W.;Hoffmann A.;Sosnowski C.;Trebacz J.;Buszman P.;Dobrzycki S.;Kornacewicz-Jach Z.;Iancu A.C.;Ginghina C.D.;Matei C.;Dobreanu D.;Bolohan F.R.;Dorobantu M.;Jacques A.;Jain A.;Bakhai A.;Gershlick A.;Adamson D.;Newby D.;Felmeden D.;Purcell I.;Edmond J.;Irving J.;De Belder M.;Pitt M.;Kelly P.;O'Kane P.;Clifford P.;Suresh V.;Secemsky E.A.;Yeh R.W.;Kereiakes D.J.;Cutlip D.E.;Cohen D.J.;Steg P.G.;Cannon C.P.;Apruzzese P.K.;D'Agostino R.B.;Massaro J.M.;Mauri L.;Kaplan A.;Ahmed A.;Ahmed A.-H.;Albirini A.;Moreyra A.;Rabinowitz A.;Shroff A.;Moak A.;Jacobs A.;Kabour A.;Gupta A.;Irimpen A.;Rosenthal A.;Taussig A.;Ferraro A.;Chhabra A.;Pucillo A.;Spaedy A.;White A. ;Pratsos A.;Shakir A.;Ghitis A.;Agarwal A.;Chawla A.;Tang A.;Barker B.;Bertolet B.;Uretsky B.;Erickson B.;Rama B.;McLaurin B.;Dearing B.;Negus B.;Price B.;Brott B.;Bhambi B.;Bowers B.;Watt B.;Donohue B.;Hassel C.D.;Croft C.;Lambert C.;O'Shaughnessy C.;Shoultz C.;Kim C.;Caputo C.;Nielson C.;Scott C.;Wolfe C.;McKenzie C.;Brachfeld C.;Thieling C.;Fisher D.;Simon D.;Churchill D.;Dobies D.;Eich D.;Goldberg D.;Griffin D.;Henderson D.;Kandzari D.;Lee D.;Lewis D.;Mego D.;Paniagua D.;Rizik D.;Roberts D.;Safley D.;Abbott D.;Shaw D.;Temizer D.;Canaday D.;Myears D.;Westerhausen D.;Ebersole D.;Netz D.;Baldwin D.;Letts D.;Harlamert E.;Kosinski E.;Portnay E.;Mahmud E.;Korban E.;Hockstad E.;Rivera E.;Shawl F.;Shamoon F.;Kiernan F.;Aycock G.R.;Schaer G.;Kunz G.;Kichura G.;Myers G.;Pilcher G.;Tadros G.;Kaddissi G.I.;Ramadurai G.;Eaton G.;Elsner G.;Mishkel G.;Simonian G.;Piegari G.;Chen H.;Liberman H.;Aronow H.;Tamboli H.P.;Dotani I.;Marin J.;Fleischhauer J.F.;Leggett J.;Mills J.;Phillips J.;Revenaugh J.;Mann J.T.;Wilson J. ;Pattanayak J.;Aji J.;Strain J.;Patel J.;Carr J.;Moses J.;Chen J.-C.;Williams J.;Greenberg J.;Cohn J.;Douglas J.;Gordon J.;Griffin J.;Hawkins J.;Katopodis J.;Lopez J.;Marshall J.;Wang J.;Waltman J.;Saucedo J.;Galichia J.;McClure M.;Kozina J.;Stella J.;Tuma J.;Kieval J.;Giri K.;Ramanathan K.;Allen K.;Atassi K.;Baran K.;Khaw K.;Clayton K.;Croce K.;Skelding K.;Patel K.;Garratt K.;Harjai K.;Chandrasekhar K.;Kalapatapu K.;Lin L.;Dean L.;Barr L.;MacDonald L.;Cannon L.;Satler L.;Gruberg L.;Tami L.;Bikkina M.;Shah M.;Atieh M.;Chauhan M.;Litt M.;Unterman M.;Lechin M.;Zughaib M.;Fisch M.;Grabarczyk M.;Greenberg M.;Lurie M.;Rothenberg M.;Stewart M.;Purvis M.;Hook M.;Leesar M.;Buchbinder M.;Weiss M.;Guerrero M.;Abu-Fadel M.;Ball M.;Chang M.;Cunningham M.;Del Core M.;Jones M.;Kelberman M.;Lim M.;Ragosta M.;Rinaldi M.;Rosenberg M.;Savage M.;Tamberella M.;Kellett M.;Vidovich M.;Effat M.;Mirza M.A.;Khan M.;Dib N.;Laufer N.;Kleiman N.;Farhat N.;Amjadi N.;Schechtmann N.;Bladuell N.;Quintana O.;Gigliotti O.;Best P.;Flaherty P.;Hall P.;Gordon P.;Gurbel P.;Ho P.;Luetmer P.;Mahoney P.;Mullen P.;Teirstein P.;Tolerico P.;Ramanathan P.;Kerwin P.;Lee P.V.;Kraft P.;Wyman R.M.;Gonzalez R.;Kamineni R.;Dave R.;Sharma R.;Prashad R.;Aycock R.;Quesada R.;Goodroe R.;Magorien R.;Randolph R.;Bach R.;Kettelkamp R.;Paulus R.;Waters R.;Zelman R.;Ganim R.;Bashir R.;Applegate R.;Feldman R.;Frankel R.;Hibbard R.;Jobe R.;Jumper R.;Maholic R.;Siegel R.;Smith R.;Stoler R.;Watson R.;Wheatley R.;Gammon R.;Hill R.;Sundrani R.;Caputo R.;Jenkins R.;Stella R.;Germanwala S.;Hadeed S.;Ledford S.;Dube S.;Gupta S.;Davis S.;Martin S.;Waxman S.;Dixon S.;Naidu S.;Potluri S.;Cook S.;Crowley S.;Kirkland S.;McIntyre S.;Thew S.;Lin S.;Marshalko S.;Guidera S.;Hearne S.;Karas S.;Manoukian S.;Rowe S.;Yakubov S.;Pollock S.;Banerjee S.;Allaqaband S.;Choi S.;Mulukutla S.;Papadakos S.;Bajwa T.;Addo T.;Schreiber T.;Haldis T.;Mathew T.
Institution:	(Secemsky) Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States (Secemsky, Yeh, Cutlip, Cannon, Mauri) Harvard Medical School, Boston, MA, United States (Secemsky, Mauri) Center for Clinical Biometrics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States (Secemsky, Yeh) Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, United States (Secemsky, Yeh, Cutlip, Cannon, Apruzzese, D'Agostino, Massaro, Mauri) Baim Institute for Clinical Research, Boston, MA, United States (Yeh, Cutlip) Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, United States (Kereiakes) Christ Hospital Heart and Vascular Center, Cincinnati, OH, United States (Kereiakes) Lindner Center for Research and Education, Cincinnati, OH, United States (Cohen) Saint Luke's Mid America Heart Institute, Kansas City, MO, United States (Cohen) University of Missouri-Kansas City, School of Medicine, Kansas City, MO, United States (Steg) Universite Paris-Diderot, Institut National de la Sante et de la Recherche Medicale U-1148, Hopital Bichat, Paris, France (Steg) Departement Hospitalo-Universitaire Fibrosis, Inflammation, and Remodeling, Assistance Publique, Hopitaux de Paris, Paris, France (Steg) National Heart and Lung Institute, Institute of Cardiovascular Medicine and Science, Royal Brompton Hospital, Imperial College, London, United Kingdom (Cannon, Mauri) Division of Cardiology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, United States (D'Agostino, Massaro) Boston University School of Public Health, Boston, MA, United States (Kaplan) Dartmouth Hitchcock Medical Center, United States (Ahmed, Ahmed) Altru Health System, United States (Albirini) Genesis HealthCare System, United States (Moreyra) University of Medicine and Dentistry of New Jersey, United States (Rabinowitz) South Texas Cardiovascular, United States (Shroff) Jesse Brown VA Medical Center, United States (Moak) Penn Presbyterian Medical Center, United States (Jacobs) Boston Medical Center, United States (Kabour) Mercy St Vincent's Medical Center, United States (Gupta) North Mississippi Medical Center, United States (Irimpen) Tulane Medical Center, United States (Rosenthal) Bayfront Medical Center, United States (Taussig, Kim) Florida Hospital, United States (Ferraro) Sacred Heart Medical Center, United States (Chhabra) Cardiovascular Research, United States (Pucillo, Kalapatapu) Westchester Medical Center, United States (Spaedy) Missouri Heart Center, United States (White) NEA Baptist Clinic, United States (Pratsos) Bryn Mawr Hospital, United States (Shakir) Midwest Regional Medical Center, United States (Ghitis) Diagnostic Cardiology Associates, United States (Agarwal, Strain) Valley Hospital, United States (Jain) California Cardiovascular Consultants Medical Associates, United States (Chawla) Iowa Heart Center, United States (Tang) Chambersburg Hospital, United States (Barker, Siegel) Arizona Regional Medical Center, United States (Bertolet) Cardiology Associates Research, United States (Uretsky) Arkansas VA Medical Center, United States (Erickson) Central Minnesota Heart Center, St Cloud Hospital, United States (Rama) Frederick C. Smith Clinic, United States (McLaurin) AnMed Health, United States (Dearing) Thomas Hospital, United States (Negus, Ledford) Chattanooga Heart Institute, United States (Price, Paulus) King's Daughters Medical Center, United States (Brott) University of Alabama at Birmingham, United States (Bhambi) Bakersfield Heart, United States (Bowers) Cardiopulmonary Research Science and Technology Institute, United States (Watt) North Central Heart Institute, United States (Donohue) University of Pittsburgh Medical Center, Shadyside Hospital, United States (Hassel, Litt) Jacksonville Heart Center, United States (Croft) Holmes Regional Medical Center, United States (Lambert) Pepin Heart Hospital, United States (O'Shaughnessy, Farhat) North Ohio Heart Center, United States (Shoultz) Providence Health Center, United States (Suresh) Derriford Hospital, United States (Caputo) North Florida Regional Medical Center, United States (Nielson) Medical University of South Carolina Hospital, United States (Scott) University of Tennessee Medical Center, United States (Wolfe) Providence St Peter Hospital, United States (McKenzie) St John's Mercy Cardio Research, United States (Brachfeld) Promise Regional Medical Center, United States (Thieling) Hattiesburg Clinic PA, United States (Fisher) UMASS Memorial Medical Center, United States (Lee) Bay Regional Medical Center, United States (Simon, Cunningham) University Hospitals Case Medical Center, United States (Churchill) Washington Regional Medical Center, United States (Dobies) Genesys Regional Medical Center, United States (Eich, Mahoney) Sentara Norfolk General Hospital, United States (Goldberg) New England Heart Institute, United States (Griffin, Temizer) Good Samaritan Hospital, United States (Henderson) Cardiology Research Associates, United States (Kandzari, Ballard) Piedmont Heart Institute, United States (Lee) Bakersfield Memorial Hospital, United States (Lewis) South Central Wisconsin Heart, United States (Mego, Flaherty) Little Rock Cardiology Clinic, United States (Paniagua) Michael E. DeBakey VA Medical Center, United States (Rizik) Scottsdale Health Care, United States (Roberts) Sacramento Heart and Vascular Institute, United States (Safley) St Luke's Hospital, United States (Abbott) Rhode Island Hospital, United States (Shaw) Christus St Frances Cabrini Hospital, United States (Clifford) Wycombe General Hospital, United States (Canaday) Inland Cardiology Associates, United States (Myears, Hawkins) St John's Medical Research Institute, United States (Westerhausen) Midwest Cardiovascular Research and Education Foundation, United States (Ebersole) Watson Clinic Center for Research, United States (Netz) Nebraska Heart Institute, United States (Baldwin) Tulane University Medical School, United States (Letts, Tamberella) Carolina Heart Specialists, United States (Harlamert, Fisch) Clarian North Medical Center, United States (Kosinski) Connecticut Clinical Research, United States (Portnay, Jumper) Cardiology Associates of Fairfield County, United States (Mahmud) UCSD Medical Center, United States (Korban) Jackson-Madison County General Hospital, United States (Hockstad) Kansas City Heart Foundation, United States (Rivera) Amarillo Heart Group, United States (Shawl) Washington Adventist Hospital, United States (Shamoon) St Michael's Medical Center, United States (Kiernan) Hartford Hospital, United States (Aycock, Fleischhauer, Stewart, Aycock) Cardiology Consultants, United States (Schaer) Rush University Medical Center, United States (Kunz) New Mexico Heart Institute PA, United States (Kichura) St John's Mercy Cardiovascular Research, United States (Myers) Redmond Regional Medical Center, United States (Pilcher) St Vincent's Healthcare, United States (Tadros) North Memorial Medical Center, United States (Kaddissi, Khaw) Our Lady of Lourdes Medical Center, United States (Ramadurai) Heartland Cardiovascular Center, United States (Eaton) Medcentral Health System, United States (Elsner, McClure, Ball) Care Group, United States (Mishkel) St John's Hospital, United States (Simonian) Hackensack University Medical Center, United States (Piegari) Berks Cardiologists, United States (Chen) Heart Center PC, United States (Liberman) Emory University Hospital Midtown, United States (Aronow) Michigan Heart and Vascular Institute, United States (Tamboli) Bay Area Cardiology Associates, United States (Dotani) McFarland Clinic PC, United States (Marin) St Joseph's Hospital, United States (O'Kane) Bournemouth Hospital, United States (Hopkins) Christiana Hospital, United States (Leggett) Over Lake Hospital Medical Center, United States (Mills) Duke Raleigh Hospital, United States (Phillips) Palmetto Richland Memorial Hospital, United States (Revenaugh) J. L. Sorenson Heart and Lung, United States (Mann, Hook, Jobe) Wake Heart Research Institute, United States (Wilson) Texas Heart Institute, United States (Pattanayak, Kuehl) Asheville Cardiology Associates, United States (Aji) Cooper University Hospital, United States (Kelly) Basildon University Hospital, United States (Patel) Hamilton Cardiology Associates, United States (Carr) East Texas Medical Center, United States (Moses) Columbia Presbyterian Hospital, United States (Chen) Straub Clinic and Hospital, United States (Williams) Mid Carolina Cardiology, United States (Greenberg, Crowley) Aurora Denver Cardiology Associates, United States (Cohn) Ingham Regional Medical Center, United States (Douglas) Emory University Hospital, United States (Gordon) Sharp Memorial Hospital, United States (Griffin) Alegent Health Research Center, United States (Griffin) Cardiovascular Associates, United States (Pitt) Heartland Hospital, United States (Katopodis) Tallahassee Research Institute, United States (Lopez) Loyola University Medical Center, United States (Marshall) Northeast Georgia Medical Center, United States (Wang) Union Memorial Hospital, United States (Waltman, Caputo, Lin) St Joseph Hospital, United States (Saucedo, Abu-Fadel) University of Oklahoma Health Science Center, United States (Galichia) Galichia Heart Hospital, United States (McClure) Mid-Michigan Heart and Vascular Center, United States (Kozina, Chang, Marquardt) Mercy General Hospital, United States (Stella, Stella) Heart Care Research Foundation, United States (Tuma) Black Hills Cardiovascular Research, United States (Kieval, Rothenberg) Palm Beach Heart Research Institute, United States (Giri) Cardiovascular Associates of Delaware Valley, United States (Ramanathan, Ramanathan) Northwest Ohio Cardiology Consultants, United States (Allen) Presbyterian Heart Group, United States (Atassi) Northwest Indiana Cardiovascular Physicians PC, United States (Baran) St Paul Heart Clinic, United States (De Belder) James Cook Hospital, United States (Clayton) Munson Medical Center, United States (Croce) Brigham and Women's Hospital, United States (Skelding) Geisinger Medical Center, United States (Patel) St Joseph Mercy Oakland, United States (Garratt, Papadakos) Lenox Hill Hospital, United States (Harjai) Donald Guthrie Foundation, United States (Chandrasekhar) Winter Haven Hospital, United States (Irving) Ninewells Hospital and MS, United States (Lin) Morton Plant Hospital, United States (Dean) University of Washington, United States (Barr, Kerwin) Midwest Heart Foundation, United States (MacDonald) Swedish Medical Center, United States (Cannon) Cardiac and Vascular Research Center of North Michigan, United States (Satler) Washington Hospital Center, United States (Gruberg) Stony Brook University Medical Center, United States (Tami) Memorial Regional Hospital, United States (Bikkina) St Joseph's Regional Medical Center, United States (Shah) Shah Associates, United States (Atieh) Pinehurst Medical Clinic, United States (Chauhan) Cardiovascular Specialists of Texas, United States (Edmond) Weston General Hospital, United States (Unterman) St Joseph's Hospital Atlanta, United States (Lechin) College Station Medical Center, United States (Zughaib, Hall) Providence Hospital, United States (Purcell) Freeman Hospital, United States (Grabarczyk) Greenville Memorial Hospital, United States (Greenberg) Moses Hospital, United States (Lurie, Wyman) Torrance Memorial Medical Center, United States (Felmeden) Torbay Hospital, United States (Newby) Royal Infirmary of Edinburgh, United States (Purvis) Medical Center of the Rockies, United States (Adamson) Coventry and Warwickshire UH, United States (Leesar, Effat) University of Cincinnati, United States (Buchbinder) Foundation for Cardiovascular Medicine, United States (Weiss) Jersey Shore University Medical Center, United States (Guerrero) Henry Ford Hospital, United States (Gershlick) Glenfield Hospital, United States (Bakhai) Barnet Hospital, United States (Jain) London Chest Hospital, United States (Jacques) St Peter's Hospital, United Kingdom (Del Core) Cardiac Center of Creighton University Medical Center, United States (Jones) Central Baptist Hospital, United States (Kelberman) St Elizabeth Medical Center, United States (Lim) St Louis University, United States (Ragosta) University of Virginia, United States (Rinaldi) Carolinas Medical Center, United States (Rosenberg) Advocate Good Shepherd Hospital, United States (Savage) Thomas Jefferson University Hospital, United States (Dorobantu) Spitalul Clinic de Urgenta Bucuresti, Romania (Bolohan) Centrul Clinic de Urgenta de Boli Cardi, Romania (Kellett) Maine Medical Center, United States (Vidovich) University of Illinois Hospital, United States (Dobreanu) Institutul de Boli Cardiovasculare si, Romania (Mirza) Carilion Medical Center, United States (Khan) North Dallas Research Associates, United States (Dib) Mercy Gilbert Medical Center, United States (Laufer) Heart and Vascular Center of Arizona, United States (Kleiman) Methodist Hospital, United States (Matei) Institutul de Urgentapentru Boli Cardiovas, Romania (Amjadi) Texas Heart and Vascular, United States (Schechtmann, Karas) MIMA Century Research Associates, United States (Bladuell) WellStar Kennestone Hospital, United States (Quintana) Hospital at Renaissance, United States (Gigliotti) Seton Heart Institute, United States (Best) Mayo Clinic, United States (Ginghina) Inst. Urgenta Boli Cardiovasculare, Romania (Iancu) Institutul Inimii Niculae Stancioiu Cluj-Napoca, Romania (Gordon) Miriam Hospital, United States (Gurbel) Sinai Center for Thrombosis Research, United States (Ho) Kaiser Foundation Hospitals, United States (Luetmer) Aspirus Heart and Vascular Institute, United States (Kornacewicz-Jach) SPSK nr 2 Pomor. AM Szczecin, Poland (Mullen) Memorial Hospital at Gulfport, United States (Teirstein) Scripps Green Hospital, United States (Tolerico, Nicholson) York Hospital, United Kingdom (Dobrzycki) Uniwer. Szpital Klin. Bialystok, Poland (Buszman) Polsko-Amerykanskie Kliniki Serca, Poland (Lee) Northeast Cardiology Associates, United States (Kraft) Beaumont Hospital Troy, United States (Trebacz) NZOZ Centr. Med. Beluga-Med, Poland (Gonzalez) Scott and White Health Care Round Rock, United States (Kamineni) Salem Hospital, United States (Dave) Spirit Physician Services, United States (Sharma) St Anthony Central Hospital, United States (Prashad) Ocala Research Institute, United States (Sosnowski) Instytut Kardiologii Kardynala Wyszynskiego, Poland (Quesada) Baptist Hospital, India (Goodroe) Grand Strand Regional Medical Center, United States (Magorien) Ohio State University Medical Center, United States (Randolph) Winchester Medical Center, United States (Bach) Washington University School of Medicine, St Louis, MO, United States (Kettelkamp) Cardiologists LC, United States (Hoffmann) Wielospecj. Szpital Miejskiim, Poland (Waters) St Joseph's Medical Center, United States (Zelman) Cape Cod Research Institute, United States (Ganim) Kingwood Medical Center, United States (Bashir) Temple University, United States (Applegate) Wake Forest University, United States (Feldman) MediQuest Munroe Regional Medical Center, United States (Frankel) Maimonides Medical Center, United States (Hibbard) Bryan LGH Medical Center, United States (Jaffe) Ascot Integrated Hospital, United States (Harding) Wellington Hospital, United Kingdom (Maholic) Hamot Medical Center, United States (Kay) Middlemore Hospital, United States (Smith) Tyler Cardiovascular Consultants, United States (Stoler) Baylor Heart and Vascular Hospital, United States (Watson) Abington Medical Specialist, United States (Wheatley) Centennial Heart, United States (Gammon) Austin Heart Research, United States (Hill) St Bernard's Medical Center, United States (Sundrani) Cardiovascular Consultants, United States (Fisher) Nelson Hospital, United States (Jenkins) Kootenai Medical Center, United States (Abernathy) Wakefield Hospital, United States (Germanwala) Longview Regional Medical Center, United States (Hadeed) Conemaugh Valley Memorial Hospital, United States (Ormiston) Mercy Angiography, United States (Dube) Indiana Heart Hospital, United States (Gupta) Oregon Health and Science University, United States (Davis) Baptist Health Medical Center, United States (Martin) Covenant Medical Center, United States (Waxman) Lahey Clinic Medical Center, United States (Dixon) William Beaumont Hospital, United States (Naidu) Winthrop University Hospital, United States (Potluri) Heart Hospital Baylor Plano, United States (Cook) Novant Clinical Research Institute, United States (Cook) Sacred Heart General Hospital, United States (Elliott) Christchurch Hospital, United States (Kirkland) Forsyth Medical Center, United States (McIntyre) Martin Memorial Health Systems, United States (Thew) Heart Clinics Northwest PS, United States (Hart) North Shore Hospital, United States (Marshalko) Bridgeport Hospital, United States (Guidera) Doylestown Hospital, United States (Hearne) Delmarva Heart Research Foundation, United States (Devlin) Waikato Hospital, New Zealand (Manoukian) Sarah Cannon Research Institute, United States (Rowe) Cox Medical Centers, United States (Yakubov) Ohio Health Research Institute, United States (Pollock) Rockingham Memorial Hospital, United States (Banerjee) VA North Texas Health Care Center, United States (Allaqaband, Bajwa) Sinai Medical Center, United States (Choi) California Pacific Medical Center Research, United States (Mulukutla) University of Pittsburgh Medical Center, United States (Koszegi) Josa Andras Oktato Korhaz Nonprofit Kft, Hungary (Forster) Szegedi Tudomanyegyetem SZ-GY, Hungary (Addo) University of Texas Southwestern Medical Center, United States (Schreiber) DMC Harper University Hospital, United States (Haldis) MeritCare Hospital Pharmacy, United States (Mathew) Slocum Dickson Medical Group, United States (McGarry) Oklahoma Foundation for Cardiovascular Research, United States (Nygaard) Cardiovascular Group, United States (Pow) Great Lakes Heart and Vascular Institute, United States (Larkin) Midwest Heart Specialists, United States (Caulfield) Providence St Vincent Medical Center, United States (Stys) Sanford Research, United States (Lee) Stanford Medical Center, United States (Mansouri) St Thomas Hospital, United States (Srinivas) Weiler Hospital, United States (Gupta) Borgess Research Institute, United States (Kancz) Gottsegen Gyorgy Orszagos Kardiologiai Intezet, Hungary (Horvath) Pecsi Tudomanyegyetem Klinikai Kozpont, Hungary (Bachinsky) Pinnacle Health, United States (Colyer) University of Toledo Medical Center, United States (Dillon) Louisville Cardiology Medical, United States (Felten) Mid-Michigan Medical Center, United States (French) LA Biomed Research Institute, United States (Lupkovics) Zala Megyei Korhaz, Hungary (Nicholas) Freeman West Hospital, United States (Rutsch) Helios Klinikum Emil von Behring, Germany (Phillips) Central Maine Medical Center, United States (Khatib, Al-Saghir) 1st Coast Cardiovascular Institute, United States (Moebius-Winkler) Herzzentrum Leipzig GmbH, Germany (Hawa) North Kansas City Hospital, United States (Masud) Kaleida Health, United States (Jafar) Hudson Valley Heart Center, United States (Muller) St Vincent's Hospital Sydney, Australia (Meredith) Monash Heart Southern Health, Australia (Rankin) Royal Perth Hospital, Australia (Worthley) Royal Adelaide Hospital, Australia (Jepson) Prince of Wales Eastern Heart, Australia (Thompson) Sir Charles Gardiner Hospital, Australia (Hendriks) Fremantle Hospital, Australia (Whitbourn) St Vincent's Hospital Melbourne, Australia (Duffy) Alfred Hospital, Australia (Stasek) FN Hradec Kralove, Czechia (Novobilsky) Mestska nemocnice Ostrava, Czechia (Naplava) Centrum pro choroby srdce, Czechia (Coufal) KNTB a.s., Czechia (Vaquette) Hopital Saint Louis, France (Bressollette) Nouvelle Clinique Nantaise, France (Teiger) CHU Henri Mondor, France (Coste) Groupe Hospitalier Sud, France (Rihani) Hopital Saint Philibert, France (Darius) Vivantes-Klinikum Neukoelln, Germany (Bergmann) Asklepios Klinik St Georg, Germany (Radke) UK-SH, Germany (Sebastian) Elbe-Kliniken Stade GmbH, Germany (Strasser) Universitaetsklinikum Dresden, Germany (Hoffmann) Vivantes Klin. Friedrichshain, Germany (Behrens) VivantesHumboldt Klinikum, Germany
Issue Date:	26-Oct-2017
Copyright year:	2017
Publisher:	American Medical Association (E-mail: smcleod@itsa.ucsf.edu)
Place of publication:	United States
Publication information:	JAMA Cardiology. 2 (5) (pp 478-487), 2017. Date of Publication: May 2017.
Abstract:	Importance: Early cardiovascular and bleeding events after coronary stenting are associated with high risk of morbidity and mortality. Objective(s): To assess the prognosis of cardiovascular and bleeding events occurring beyond 1 year after coronary stenting. Design, Setting, and Participant(s): This secondary analysis is derived from data from the Dual Antiplatelet Therapy (DAPT) Study, a multi center trial involving 220 US and in ternational clinical sites from 11 countries. The study dateswere August 2009 to May 2014. Individuals who underwent coronary stenting and completed 12 months of thienopyridine plus aspirin therapy without ischemic or bleeding events remained on an aspirin regimen and were randomized to continued thienopyridine therapy vs placebo for 18 additional months. Individuals were then followed up for 3 additional months while receiving aspirin therapy alone. The analysis began in August 2015. Exposures: Ischemic events (myocardial infarction not related to stent thrombosis, stent thrombosis, and ischemic stroke) and bleeding events (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries [GUSTO] classification moderate or severe bleeding). Main Outcomes and Measures: Ischemic events (myocardial infarction not related to stent thrombosis, stent thrombosis, and ischemic stroke) and bleeding events (GUSTO classification moderate or severe bleeding). Death at 21 months after randomization (33 months after coronary stenting). Result(s): Intotal, 25 682 individuals older than 18 years with an indication for coronarystentingwere enrolled, and 11 648(meanage,61.3 years; 25.1%female)were randomized. After randomization, 478 individuals (4.1%) had 502 ischemic events (306 with myocardial infarction, 113 with stent thrombosis, and 83 with ischemic stroke), and 232 individuals (2.0%) had 235 bleeding events (155 with moderate and 80 with severe bleeding). Among individuals with ischemic events, 52(10.9%) died. The annualized mortality rate after an ischemic event was 27.2 (95%CI, 20.3-35.7) per 100 person-years. The cumulative incidence of death after an ischemic event among the total randomized study population was 0.5%(0.3% with myocardial infarction,0.1% with stent thrombosis, and 0.1% with ischemic stroke). Among individuals with bleeding events, 41 (17.7%) died. The annualized mortality rate after a bleeding event was 21.5 (95%CI, 15.4-29.1) per 100 person-years. The cumulative incidence of death after a bleeding event among the total randomized study population was 0.3%(0.1% with moderate and 0.2% with severe bleeding). Conclusions and Relevance: In patients treated with dual antiplatelet therapy for at least 1 year after coronary stenting, ischemic events were more frequent than bleeding events, and both events were associated with high risk of mortality.Copyright © 2017 American Medical Association. All rights reserved.
DOI:	http://monash.idm.oclc.org/login?url=http://acs.hcn.com.au/?acc=36265&url=http://dx.doi.org/10.1001/jamacardio.2017.0063
Link to associated publication:	Click here for full text options
ISSN:	2380-6583
URI:	https://repository.monashhealth.org/monashhealthjspui/handle/1/38257
Type:	Article
Subjects:	stent thrombosis/co [Complication] adult aged article bleeding/si [Side Effect] brain ischemia cardiovascular disease controlled study coronary artery disease/dt [Drug Therapy] coronary artery disease/su [Surgery] coronary stenting disease association disease classification disease severity double blind procedure drug fatality/si [Side Effect] female follow up heart infarction human major clinical study male mortality multicenter study postoperative period priority journal prognosis randomized controlled trial secondary analysis United States acetylsalicylic acid/cb [Drug Combination] acetylsalicylic acid/dt [Drug Therapy] placebo thienopyridine derivative/ae [Adverse Drug Reaction] thienopyridine derivative/ct [Clinical Trial] thienopyridine derivative/cb [Drug Combination] thienopyridine derivative/cm [Drug Comparison] thienopyridine derivative/dt [Drug Therapy] bare metal stent/am [Adverse Device Effect] drug eluting coronary stent/am [Adverse Device Effect] paclitaxel eluting coronary stent/am [Adverse Device Effect] Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Arteries classification stent thrombosis / complication United States major clinical study human heart infarction follow up female drug fatality / side effect double blind procedure disease severity disease classification disease association cardiovascular disease mortality multicenter study postoperative period priority journal prognosis randomized controlled trial secondary analysis Article bleeding / side effect brain ischemia male controlled study coronary artery disease / drug therapy / surgery *coronary stenting adult aged
Type of Clinical Study or Trial:	Randomised controlled trial
Appears in Collections:	Articles

Show full item record

Page view(s)

116

checked on Aug 17, 2024

Google Scholar^TM

Check

Page view(s)

Google ScholarTM

Google Scholar^TM