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https://repository.monashhealth.org/monashhealthjspui/handle/1/38430| Title: | Genomic characterisation of Emu-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene. | Authors: | Papenfuss A.T.;Lupat R.;Li J.;Schroeder J.;Wall M.;Poortinga G.;Cameron D. ;Bywater M.;Kats L.;Gearhart M.D.;Bardwell V.J.;Dickins R.A.;Hannan R.D.;Johnstone R.W.;Shortt J. ;Craig S. ;Lefebure M.;Tothill R.W.;Kruse E.;Hawkins E.D.;Matthews G.M.;Gregory G.P.;Martin B.P.;Kelly M.J.;Todorovski I.;Doyle M.A. | Institution: | (Lefebure, Tothill, Kruse, Shortt, Gregory, Martin, Kelly, Todorovski, Doyle, Lupat, Li, Craig, Poortinga, Cameron, Bywater, Kats, Hannan, Papenfuss, Johnstone) Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia (Lefebure, Tothill, Kats, Papenfuss, Johnstone) Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3052, Australia (Tothill) Department of Pathology, University of Melbourne, Parkville, VIC 3052, Australia (Hawkins, Schroeder, Papenfuss) Walter Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia (Shortt) School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Clayton, VIC 3168, Australia (Matthews) Dana Farber Cancer Institute, Boston, MA 02115, United States (Wall) Victorian Cancer Cytogenetics Service, St Vincent's Hospital, Fitzroy, VIC 3065, Australia (Wall) Department of Medicine, St Vincent's Hospital, University of Melbourne, Parkville, VIC 3052, Australia (Gearhart, Bardwell) Developmental Biology Center, Masonic Cancer Center, Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, United States (Dickins) Australian Centre for Blood Diseases, Monash University, AMREP Building, Alfred Hospital, Commercial Road, Melbourne, VIC 3004, Australia (Hannan) Cancer Biology and Therapeutics Department, John Curtin School of Medical Research, Australian National University, Canberra Australian Capital Territory 0200, Australia | Issue Date: | 17-Mar-2017 | Copyright year: | 2017 | Publisher: | Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom) | Place of publication: | United Kingdom | Publication information: | Nature Communications. 8 (no pagination), 2017. Article Number: 14581. Date of Publication: 06 Mar 2017. | Journal: | Nature Communications | Abstract: | The Emu-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Emu-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Emu-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.Copyright © 2017 The Author(s). | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/ncomms14581 | PubMed URL: | 28262675 [http://www.ncbi.nlm.nih.gov/pubmed/?term=28262675] | ISSN: | 2041-1723 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/38430 | Type: | Article |
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