Please use this identifier to cite or link to this item:
https://repository.monashhealth.org/monashhealthjspui/handle/1/38765
Title: | Efficacy of predictive models for polycystic ovary syndrome using serum levels of two antimullerian hormone isoforms (proAMH and AMHN,C). | Authors: | Rodgers R.J.;Moran L.J.;Pankhurst M.W.;Shorakae S.;Teede H.J. | Institution: | (Pankhurst) Department of Anatomy, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand (Rodgers, Moran) The Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia (Shorakae, Teede, Moran) Monash Centre for Health Research Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia (Shorakae, Teede) Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Victoria, Australia | Issue Date: | 14-Nov-2017 | Copyright year: | 2017 | Publisher: | Elsevier Inc. (E-mail: usjcs@elsevier.com) | Place of publication: | United States | Publication information: | Fertility and Sterility. 108 (5) (pp 851-857.e2), 2017. Date of Publication: November 2017. | Journal: | Fertility and Sterility | Abstract: | Objective To compare total antimullerian hormone (AMH), proAMH, AMHN,C, and the ratio of the two forms in predictive models for polycystic ovary syndrome (PCOS) diagnosis. Total AMH consists of proAMH (inactive precursor) and AMHN,C (receptor-competent), but neither isoform has been tested individually for their ability to predict PCOS diagnosis. Design Cross-sectional study using biobanked samples collected between July 2008 and January 2010. Setting Not applicable. Patient(s) Overweight, premenopausal women aged 18-45 years with PCOS (n = 45, with 21 fulfilling National Institutes of Health diagnostic criteria and 24 fulfilling European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE) criteria, but not National Institutes of Health criteria) and without PCOS (n = 23 controls). Intervention(s) None. Main Outcome Measure(s) Serum concentrations of proAMH and total AMH (proAMH and AMHN,C combined) were determined by immunoassay. The AMHN,C concentrations were calculated by subtraction ([AMHN,C] = [total AMH] - [proAMH]). Relative levels of proAMH were expressed as the AMH prohormone index (API = [ProAMH]/[Total AMH] x 100). Result(s) In women with PCOS, total AMH, proAMH, and AMHN,C levels were higher, and the API was lower (P=.010), than in controls indicating increased conversion of proAMH to AMHN,C. Receiver-operating characteristic analysis for proAMH (area under the curve [AUC] = 0.82), AMHN,C (AUC = 0.86), and API (AUC = 0.70) did not improve the prediction for PCOS when compared with total AMH (AUC = 0.86). Conclusion(s) The proAMH and AMHN,C do not appear to improve the ability to predict a diagnosis of PCOS beyond total AMH assays. However, the ratio of inactive proAMH precursor to receptor-competent AMHN,C (API) differs in women with PCOS relative to unaffected controls indicating that AMH signaling mechanisms may be altered in women with PCOS.Copyright © 2017 American Society for Reproductive Medicine | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.fertnstert.2017.08.012 | Link to associated publication: | Click here for full text options | PubMed URL: | 29079276 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29079276] | ISSN: | 0015-0282 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/38765 | Type: | Article | Subjects: | *ovary polycystic disease premenopause priority journal *Muellerian inhibiting factor/ec [Endogenous Compound] waist circumference adult anovulation article blood sampling body mass body weight clinical effectiveness controlled study cross-sectional study female *hormone blood level hormone determination human hyperandrogenism immunoassay major clinical study obesity priority journal adult anovulation Article blood sampling body mass body weight clinical effectiveness controlled study cross-sectional study female *hormone blood level hormone determination human hyperandrogenism immunoassay major clinical study obesity *ovary polycystic disease premenopause waist circumference |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
Show full item record
Items in Monash Health Research Repository are protected by copyright, with all rights reserved, unless otherwise indicated.