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Title: | Immunotherapeutic strategies in antiphospholipid syndrome. | Authors: | Ross L.;Buchanan R.R.C.;Day J.;Hoi A.Y. | Institution: | (Hoi, Ross, Day, Buchanan) Department of Rheumatology, Austin Health, Melbourne, VIC, Australia (Hoi) Department of Rheumatology, Monash Health, Melbourne, VIC, Australia (Hoi) School of Clinical Sciences, Monash University, Melbourne, VIC, Australia | Issue Date: | 11-Mar-2017 | Copyright year: | 2017 | Publisher: | Blackwell Publishing (E-mail: info@asia.blackpublishing.com.au) | Place of publication: | Australia | Publication information: | Internal Medicine Journal. 47 (3) (pp 250-256), 2017. Date of Publication: 01 Mar 2017. | Journal: | Internal Medicine Journal | Abstract: | Antiphospholipid syndrome is an autoimmune condition, characterised by the persistent presence of antiphospholipid antibodies and either thrombosis or obstetric morbidity. The cornerstone of therapy is long-term anticoagulation to reduce morbidity and mortality; however, better understanding of the immunological pathways may direct us to develop future therapeutic strategies. We provide an overview of the current understanding of the immunopathogenesis of this perplexing condition and its associated morbidities and current evidence for some of the immunotherapeutic strategies.Copyright © 2017 Royal Australasian College of Physicians | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/imj.13245 | PubMed URL: | 27572264 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27572264] | ISSN: | 1444-0903 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/38810 | Type: | Review | Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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