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Conference/Presentation Title: | Follow-up recommendations for completely resected gastroenteropancreatic neuroendocrine tumours (GEP-NETs): Consensus guidelines from the Commonwealth NET collaboration (CommNETs) in conjunction with the North American NET Society (NANETS). | Authors: | Chan D.;Moody L.;Metz D. ;Segelov E. ;Strosberg J.;Singh S. | Monash Health Department(s): | Oncology | Institution: | (Singh, Chan) Medical Oncology, Sunnybrook Odette Cancer Center, Sunnybrook HSC, Toronto, ON, Canada (Moody) IHPME, University of Toronto, Toronto, ON, Canada (Metz) Gastroenterology, University of Pennsylvania, School of Medicine, Philadelphia, PA, United States (Strosberg) GI Oncology, Moffitt Cancer Center, Tampa, FL, United States (Segelov) Medical Oncology, Monash University and Monash Health, Melbourne, Australia | Presentation/Conference Date: | 14-Dec-2017 | Copyright year: | 2017 | Publisher: | Oxford University Press | Publication information: | Annals of Oncology. Conference: 42nd ESMO Congress, ESMO 2017. Madrid Spain. 28 (Supplement 5) (pp v147), 2017. Date of Publication: September 2017. | Abstract: | Background: NETs are uncommon, and there is no consensus regarding the optimal follow-up frequency or modality after resection. Current follow-up guidelines for resected GEP-NETs are based on limited evidence and our large, international practice survey showed poor compliance by NET expert clinicians. A need for clear and practical guidelines was identified. Method(s): A RAND/UCLA appropriateness process was employed given the lack of published data. A systematic review was undertaken as well as a multi-national practice survey to understand current follow-up patterns. Results from two large retrospective reviews (Ontario, Canada and Tampa, Florida) examining outcome following curative surgery were obtained. An 18-member multidisciplinary international panel scored 193 clinical scenarios for appropriateness of timing of consultations and investigations for detecting recurrence on a 1-9 scale. At a face-to-face consensus conference, the final follow-up recommendations were developed. Result(s): Twelve studies were identified describing follow-up strategies post-resection, with only one comparing follow-up strategies. Data from our practice survey (n=163) and our population-based study (n=936) are separately reported. Based on the scenario scoring, the panel resolved 14 summary statements, with the major themes of (1) less frequent follow up visits and investigations within the first five years (2) longer follow up even beyond 10 years (3) different recommendations for pancreatic versus gastrointestinal NETs (4) identification of low risk subgroups where no routine followup was recommended (5) no role for any serum or urine biomarkers, or chest imaging (6) the need to evaluate functional imaging in follow-up. Conclusion(s): Streamlined, practical guidelines were developed for the follow-up of patients with resected GEP-NETs. These guidelines differ significantly from other current guidelines. The expert consensus was informed by previously unavailable large outcome datasets. Compliance, cost-effectiveness and patient acceptability will be evaluated in future studies. | Conference Start Date: | 2017-09-08 | Conference End Date: | 2017-09-12 | ISSN: | 1569-8041 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/39009 | Type: | Conference Abstract | Subjects: | *follow up *gastroenteropancreatic neuroendocrine tumor gastrointestinal tract human human tissue male Ontario pancreas relapse retrospective study surgery systematic review thorax urine biological marker cost effectiveness analysis adult female Florida consultation relapse retrospective study surgery systematic review thorax urine human tissue human gastrointestinal tract *gastroenteropancreatic neuroendocrine tumor male Florida female cost effectiveness analysis *follow up Ontario pancreas consultation adult |
Type of Clinical Study or Trial: | Systematic review and/or meta-analysis |
Appears in Collections: | Conferences |
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