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https://repository.monashhealth.org/monashhealthjspui/handle/1/39424| Title: | Polyclonal emergence of vanA vancomycin-resistant Enterococcus faecium in Australia. | Authors: | Jensen S.O.;van Hal S.J.;Espedido B.A.;Coombs G.W.;Howden B.P.;Korman T. ;Nimmo G.R.;Gosbell I.B. | Institution: | (van Hal, Espedido, Gosbell, Jensen) School of Medicine, Western Sydney University, Sydney, NSW, Australia (van Hal) Royal Prince Alfred Hospital, Sydney, NSW, Australia (Espedido, Gosbell, Jensen) Antimicrobial Resistance and Mobile Elements Group, Ingham Institute for Applied Medical Research, Sydney, NSW, Australia (Coombs) School of Veterinary and Life Sciences, Murdoch University, Perth, WA, Australia (Coombs) PathWest Laboratory Medicine, Fiona Stanley Hospital, Perth, WA, Australia (Howden) Austin Health, Melbourne, VIC, Australia (Howden) Department of Microbiology and Immunology, The University of Melbourne, Melbourne, VIC, Australia (Korman) Monash Hospital, Melbourne, VIC, Australia (Nimmo) Pathology Queensland, Brisbane, QLD, Australia (Gosbell) Sydney South Western Pathology Service, NSW Pathology, Sydney, NSW, Australia | Issue Date: | 19-May-2017 | Copyright year: | 2017 | Publisher: | Oxford University Press (E-mail: jnl.info@oup.co.uk) | Place of publication: | United Kingdom | Publication information: | Journal of Antimicrobial Chemotherapy. 72 (4) (pp 998-1001), 2017. Date of Publication: 2017. | Journal: | Journal of Antimicrobial Chemotherapy | Abstract: | Objectives: To investigate the genetic context associated with the emergence of vanA VRE in Australia. Method(s): The whole genomes of 18 randomly selected vanA-positive Enterococcus faecium patient isolates, collected between 2011 and 2013 from hospitals in four Australian capitals, were sequenced and analysed. Result(s): In silico typing and transposon/plasmid assembly revealed that the sequenced isolates represented (in most cases) different hospital-adapted STs and were associated with a variety of different Tn1546 variants and plasmid backbone structures. Conclusion(s): The recent emergence of vanA VRE in Australia was polyclonal and not associatedwith the dissemination of a single 'dominant' ST or vanA-encoding plasmid. Interestingly, the factors contributing to this epidemiological change are not known and future studies may need to consider investigation of potential community sources.Copyright © The Author 2016. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1093/jac/dkw539 | PubMed URL: | 28031272 [http://www.ncbi.nlm.nih.gov/pubmed/?term=28031272] | ISSN: | 0305-7453 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/39424 | Type: | Article |
| Appears in Collections: | Articles |
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