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Title: | Interferon beta-1a long-term therapy related to pulmonary arterial hypertension in multiple sclerosis patients. | Authors: | Williams T.;McLean C.A.;Butler E. ;Fok A. | Institution: | (Fok) Department of Ophthalmology & Visual Sciences, Faculty of Medicine, Eye Care Centre (Vancouver General Hospital), Vancouver, BC, Canada (Fok, Butler) Department of Neurosciences, Monash Health, Melbourne, VIC, Australia (Williams) Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital and Monash University, Melbourne, VIC, Australia (McLean) Department of Anatomical Pathology, Alfred Hospital, Melbourne, VIC, Australia | Issue Date: | 27-Dec-2017 | Copyright year: | 2016 | Publisher: | SAGE Publications Ltd (E-mail: info@sagepub.co.uk) | Place of publication: | United Kingdom | Publication information: | Multiple Sclerosis Journal. 22 (11) (pp 1495-1498), 2016. Date of Publication: 01 Oct 2016. | Journal: | Multiple Sclerosis Journal | Abstract: | We report two patients with relapsing remitting multiple sclerosis (RRMS) on interferon (IFN) beta-1a treatment for more than 7 years who developed pulmonary arterial hypertension (PAH). Patient 1 developed severe PAH requiring lung transplantation. Histology showed typical proliferative lesions including plexiform lesions consistent with PAH. Patient 2 ceased IFN beta-1a, and their symptoms stabilised. Both cases highlight IFN beta-1a treatment as a potential risk factor for PAH. PAH needs to be considered as a diagnosis in patients on long-term IFN beta-1a treatment who develop new-onset respiratory symptoms.Copyright © The Author(s), 2015. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1177/1352458515618020 | ISSN: | 1352-4585 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/39587 | Type: | Article | Type of Clinical Study or Trial: | Case series or case report |
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