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Title: | Neuregulin-1 and schizophrenia in the genome-wide association study era. | Authors: | Pantelis C.;Karl T.;Weickert C.S.;Everall I.P.;Pereira A.;Bousman C.A.;Sundram S. ;Mostaid M.S.;Liberg B.;Lloyd D. | Institution: | (Mostaid, Liberg, Pantelis, Everall, Bousman) Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia (Sundram, Pereira, Pantelis, Everall, Bousman) Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia (Lloyd, Karl, Weickert) Schizophrenia Research Institute, Sydney, Australia (Sundram, Everall) NorthWestern Mental Health, Melbourne, VIC, Australia (Bousman) The University of Melbourne, Department of General Practice, Parkville, VIC, Australia (Bousman) Swinburne University of Technology, Centre for Human Psychopharmacology, Hawthorn, VIC, Australia (Karl) Western Sydney University, School of Medicine, Campbelltown, NSW, Australia (Sundram) Monash University, Department of Psychiatry, Monash Medical Centre, Monash Health, Clayton, VIC, Australia (Lloyd, Weickert) Schizophrenia Research Laboratory, Neuroscience Research Australia, Barker Street, Sydney, Australia (Lloyd, Weickert) School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia | Issue Date: | 30-Jun-2016 | Copyright year: | 2016 | Publisher: | Elsevier Ltd | Place of publication: | United Kingdom | Publication information: | Neuroscience and Biobehavioral Reviews. 68 (pp 387-409), 2016. Date of Publication: 01 Sep 2016. | Journal: | Neuroscience and Biobehavioral Reviews | Abstract: | Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical component in the pathophysiology of schizophrenia. However, the arrival of the genome-wide association study (GWAS) era has yielded results that challenge the relevance of NRG1 in schizophrenia due to the absence of a genome-wide significant NRG1 variant associated with schizophrenia. To assess NRG1's relevance to schizophrenia in the GWAS era, we provide a targeted review of recent preclinical evidence on NRG1's role in regulating several aspects of excitatory/inhibitory neurotransmission and in turn schizophrenia risk. We also present a systematic review of the last decade of clinical research examining NRG1 in the context of schizophrenia. We include concise summaries of genotypic variation, gene-expression, protein expression, structural and functional neuroimaging as well as cognitive studies conducted during this time period. We conclude with recommendations for future clinical and preclinical work that we hope will help prioritize a strategy forward to further advance our understanding of the relationship between NRG1 and schizophrenia.Copyright © 2016 Elsevier Ltd. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.neubiorev.2016.06.001 | PubMed URL: | 27283360 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27283360] | ISSN: | 0149-7634 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/39778 | Type: | Review | Subjects: | *schizophrenia/et [Etiology] schizophrenia/dt [Drug Therapy] single nucleotide polymorphism messenger RNA/ec [Endogenous Compound] *neu differentiation factor/ec [Endogenous Compound] neuroleptic agent/dt [Drug Therapy] excitatory neurotransmission inhibitory neurotransmission *NRG1 gene nonhuman drug response functional neuroimaging gene expression gene function gene interaction *genetic association genetic risk genetic variation genotype environment interaction high risk population human neuroimaging neuropathology neurotransmission phenotype priority journal protein expression protein structure quantitative trait locus review risk assessment *schizophrenia/dt [Drug Therapy] neuroimaging neuropathology neurotransmission nonhuman phenotype functional neuroimaging protein expression protein structure quantitative trait locus Review risk assessment *schizophrenia / *drug therapy / *etiology schizophrenia / drug therapy single nucleotide polymorphism drug response priority journal gene expression gene function gene interaction *genetic association genetic risk genetic variation genotype environment interaction high risk population human |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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