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Title: | Clinical associations of IL-10 and IL-37 in systemic lupus erythematosus. | Authors: | Harris J.;Rudloff I.;Kandane-Rathnayake R.;Hoi A. ;Nold M.F.;Morand, Eric ;Godsell J. | Monash Health Department(s): | Rheumatology | Institution: | (Godsell, Kandane-Rathnayake, Hoi, Morand, Harris) Rheumatology Group, Centre for Inflammatory Diseases, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing &Health Sciences, Monash University, Clayton, Victoria, Australia (Rudloff, Nold) Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia (Rudloff, Nold) Department of Paediatrics, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing &Health Sciences, Monash University, Clayton, Victoria, Australia | Issue Date: | 29-Jun-2018 | Copyright year: | 2016 | Place of publication: | United Kingdom | Publication information: | Scientific reports. 6 (pp 34604), 2016. Date of Publication: 06 Oct 2016. | Abstract: | Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the development of autoantibodies to nuclear antigens and inflammatory responses mediated by multiple cytokines. Although previous studies have determined clinical associations between SLE and the anti-inflammatory cytokines IL-10 and IL-37, their role in the disease, or their potential as biomarkers, remains unclear. We examined serum levels of IL-10 and IL-37 in a large cohort of SLE patients, with detailed longitudinal clinical data. We demonstrate a statistically significant association of serum IL-10 with disease activity, with higher levels in active compared to inactive disease. High first visit IL-10 was predictive of high subsequent disease activity; patients with IL-10 in highest quartile at first visit were 3.6 times more likely to have active disease in subsequent visits. Serum IL-37 was also higher in SLE patients compared to control, and was strongly associated with Asian ethnicity. However, IL-37 was not statistically significantly associated with disease activity. IL-37 was significantly reduced in patients with organ damage but this association was attenuated in multivariable analysis. The data suggest that IL-10, but not IL-37, may have potential as a biomarker predictive for disease activity in SLE. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/srep34604 | Link to associated publication: | Click here for full text options | PubMed URL: | 27708376 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27708376] | ISSN: | 2045-2322 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/40423 | Type: | Article | Subjects: | male interleukin 1 interleukin 10 IL10 protein, human IL37 protein, human adolescent adult aged blood clinical trial female human biological marker middle aged systemic lupus erythematosus/dt [Drug Therapy] very elderly human female clinical trial aged adult adolescent very elderly systemic lupus erythematosus / drug therapy middle aged male blood |
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