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Title: | Ovarian hyperstimulation syndrome: A case control study investigating risk factors. | Authors: | Shields R.;Vollenhoven B. ;Ahuja K.;Talmor A. | Institution: | (Shields, Vollenhoven, Talmor) Monash Medical Centre, Monash Health, Melbourne, VIC, Australia (Ahuja) School of Health Sciences, University of Tasmania, Launceston, TAS, Australia | Issue Date: | 30-Mar-2017 | Copyright year: | 2016 | Publisher: | Blackwell Publishing (E-mail: info@asia.blackpublishing.com.au) | Place of publication: | Australia | Publication information: | Australian and New Zealand Journal of Obstetrics and Gynaecology. 56 (6) (pp 624-627), 2016. Date of Publication: 01 Dec 2016. | Journal: | Australian and New Zealand Journal of Obstetrics and Gynaecology | Abstract: | Background: Ovarian hyperstimulation syndrome (OHSS) is a complication of in vitro fertilisation (IVF) treatment associated with significant morbidity and mortality. Aim(s): To assess the severity of OHSS in patients admitted to a tertiary hospital in Melbourne, Australia, and identify risk factors for the condition. Material(s) and Method(s): The files of patients admitted with OHSS over a five-year period between 2008 and 2013 were reviewed. Baseline characteristics of OHSS patients were compared with IVF patients who did not develop OHSS to establish risk factors for the OHSS patient group. Relative risk was estimated using multivariate Poisson regression. A risk score was then developed using the coefficients from the Poisson regression to aid identification of patients at high risk for the condition. Result(s): The following risk factors were associated with an increased risk of developing OHSS: younger age, higher oestradiol (E2) concentration (relative risk (RR) 1.43, P < 0.001), and higher follicle count (RR 1.40, P < 0.001). Lower body mass index (BMI) was not correlated with an increased risk of developing OHSS (RR 1.1, P = 0.19). Conclusion(s): This study demonstrates that a risk score can be calculated from routinely taken measurements to identify patients at high risk of OHSS. Using this risk score could help clinicians reduce the incidence of OHSS by employing preventative strategies in high-risk patients.Copyright © 2016 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1111/ajo.12515 | Link to associated publication: | Click here for full text options | PubMed URL: | 27531056 [http://www.ncbi.nlm.nih.gov/pubmed/?term=27531056] | ISSN: | 0004-8666 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/40476 | Type: | Article | Subjects: | in vitro fertilization injection site cellulitis/co [Complication] intensive care unit laparoscopy length of stay medical record review ovary cyst/co [Complication] ovary follicle *ovary hyperstimulation/et [Etiology] ovary torsion/co [Complication] priority journal risk assessment *risk factor supraventricular tachycardia/co [Complication] tertiary care center urinary tract infection/co [Complication] estradiol/ec [Endogenous Compound] major clinical study acute kidney failure/co [Complication] adult age article ascites body mass case control study controlled study correlational study deep vein thrombosis/co [Complication] disease severity estradiol blood level female high risk patient hospital admission hospitalization human estradiol blood level female high risk patient age hospitalization human in vitro fertilization injection site cellulitis / complication intensive care unit laparoscopy length of stay major clinical study medical record review ovary cyst / complication ovary follicle *ovary hyperstimulation / *etiology ovary torsion / complication priority journal risk assessment *risk factor supraventricular tachycardia / complication tertiary care center urinary tract infection / complication adult acute kidney failure / complication hospital admission Article ascites body mass case control study controlled study correlational study deep vein thrombosis / complication disease severity |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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