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https://repository.monashhealth.org/monashhealthjspui/handle/1/40620| Title: | Pseudomonas aeruginosa genotypes acquired by children with cystic fibrosis by age 5-years. | Authors: | Tiddens H.A.;Mott L.;Gerbrands K.;Graniel K.;Kidd T.J.;Ramsay K.A.;Vidmar S.;Carlin J.B.;Bell S.C.;Wainwright C.E.;Grimwood K.;Francis P.W.;Dakin C.;Cheney J.;George N.;Robertson C.F.;Moodie M.;Carzino R.;Carter R.;Armstrong D.S.;Cooper P.J.;McKay K.;Martin A.J.;Whitehead B.;Hunter J.;Byrnes C.A. | Institution: | (Wainwright, Cheney) The University of Queensland, Brisbane, Australia (Grimwood) Griffith University, Brisbane, Australia (Francis) Royal Children's Hospital, Brisbane, Australia (Dakin) Mater Children's Hospital, Brisbane, Australia (George) Pathology Queensland, Brisbane, Australia (Vidmar, Carlin) Murdoch Childrens Research Institute, Melbourne, Australia (Vidmar, Carlin) Department of Paediatrics, University of Melbourne, Melbourne, Australia (Robertson, Carzino) Royal Children's Hospital, Melbourne, Australia (Moodie, Carter) Deakin University, Melbourne, Australia (Armstrong) Monash Medical Centre, Melbourne, Australia (Cooper, McKay) The Children's Hospital at Westmead, Sydney, Australia (Martin) Women's and Children's Hospital, Adelaide, Australia (Hunter) Children's Hospital, Newcastle, Australia (Byrnes) Starship Children's Hospital, Auckland, New Zealand (Tiddens) Erasmus Medical Centre, Rotterdam, Netherlands (Kidd, Ramsay, Bell, Wainwright, Grimwood) Queensland Children's Medical Research Institute, Royal Children's Hospital, The University of Queensland, Herston, QLD 4029, Australia (Vidmar, Carlin, Whitehead, Graniel, Gerbrands, Mott) Clinical Epidemiology and Biostatistics Unit, Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia (Bell) Department of Thoracic Medicine, The Prince Charles Hospital, Chermside, QLD 4032, Australia (Wainwright) Queensland Children's Respiratory Centre, Royal Children's Hospital, Herston, QLD 4029, Australia (Grimwood) Griffith Health Institute, Griffith University and Gold Coast University Hospital, Southport, QLD 4222, Australia | Issue Date: | 28-Jul-2015 | Copyright year: | 2015 | Publisher: | Elsevier B.V. | Place of publication: | Netherlands | Publication information: | Journal of Cystic Fibrosis. 14 (3) (pp 361-369), 2015. Date of Publication: 01 May 2015. | Journal: | Journal of Cystic Fibrosis | Abstract: | Background: We describe Pseudomonas aeruginosa acquisitions in children with cystic fibrosis (CF) aged <=. 5-years, eradication treatment efficacy, and genotypic relationships between upper and lower airway isolates and strains from non-CF sources. Method(s): Of 168 CF children aged <=. 5-years in a bronchoalveolar lavage (BAL)-directed therapy trial, 155 had detailed microbiological results. Overall, 201/271 (74%) P. aeruginosa isolates from BAL and oropharyngeal cultures were available for genotyping, including those collected before and after eradication therapy. Result(s): Eighty-two (53%) subjects acquired P. aeruginosa, of which most were unique strains. Initial eradication success rate was 90%, but 36 (44%) reacquired P. aeruginosa, with genotypic substitutions more common in BAL (12/14) than oropharyngeal (3/11) cultures. Moreover, oropharyngeal cultures did not predict BAL genotypes reliably. Conclusion(s): CF children acquire environmental P. aeruginosa strains frequently. However, discordance between BAL and oropharyngeal strains raises questions over upper airway reservoirs and how to best determine eradication in non-expectorating children.Copyright © 2014 European Cystic Fibrosis Society. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1016/j.jcf.2014.12.007 | PubMed URL: | 25563522 [http://www.ncbi.nlm.nih.gov/pubmed/?term=25563522] | ISSN: | 1569-1993 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/40620 | Type: | Article |
| Appears in Collections: | Articles |
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