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Title: | Candida infective endocarditis: An observational cohort study with a focus on therapy. | Authors: | Campagnac C.;Llopis J.;Marco F.;Mestres C.A.;Moreno A.;Ninot S.;Pare C.;Pericas J.M.;Ramirez J.;Rovira I.;Sitges M.;Tattevin P.;Strahilevitz J.;Spelman D.;Athan E.;Nacinovich F.;Lamas C.;Barsic B.;Fernandez-Hidalgo N.;Munoz P.;Chu V.H.;Anguera I.;Clara L.;Sanchez M.;Casabe J.;Cortes C.;Oses P.F.;Ronderos R.;Sucari A.;Thierer J.;Altclas J.;Kogan S.;Font B.;Harris O.;Kennedy K.;Tan R.;Gordon D.;Papanicolas L.;Korman T. ;Kotsanas D.;Dever R.;Jones P.;Konecny P.;Guma J.R.;Lawrence R.;Rees D.;Ryan S.;Feneley M.P.;Harkness J.;Post J.;Reinbott P.;Gattringer R.;Wiesbauer F.;Andrade A.R.;Bermejo J.;De Brito A.C.P.;Guimaraes A.C.;Grinberg M.;Mansur A.J.;Siciliano R.F.;Strabelli T.M.V.;Vieira M.L.C.;De Medeiros Tranchesi R.A.;Paiva M.G.;Fortes C.Q.;Bouza E.;De Oliveira Ramos A.;Weksler C.;Ferraiuoli G.;Golebiovski W.;Karlowsky J.A.;Keynan Y.;Morris A.M.;Rubinstein E.;Jones S.B.;Garcia P.;Leoni M.E.G.;Cereceda M.;Fica A.;Mella R.M.;Fernandez R.;Franco L.;Gonzalez J.;Jaramillo A.N.;Bukovski S.;Krajinovic V.;Pangercic A.;Robles J.A.G.;Rudez I.;Vincelj J.;Freiberger T.;Pol J.;Zaloudikova B.;Ashour Z.;Kholy A.E.;Mishaal M.;Osama D.;Rizk H.;Ramallo V.G.;Aissa N.;Alauzet C.;Alla F.;Doco-Lecompte T.;Selton-Suty C.;Casalta J.-P.;Fournier P.-E.;Habib G.;Raoult D.;Thuny F.;Cruz A.F.;Delahaye F.;Delahaye A.;Vandenesch F.;Donal E.;Donnio P.Y.;Flecher E.;Michelet C.;Revest M.;Chevalier F.;Jeu A.;Kestler M.;Remadi J.P.;Rusinaru D.;Tribouilloy C.;Bernard Y.;Chirouze C.;Hoen B.;Leroy J.;Plesiat P.;Naber C.;Neuerburg C.;Marin M.;Mazaheri B.;Helen G.;Sofia A.;Ioannis D.;Thomas T.;Mylona E.;Paniara O.;Papanicolaou K.;Pyros J.;Skoutelis A.;Selles M.M.;Sharma G. ;Francis J.;Nair L.;Thomas V.;Venugopal K.;Hannan M.M.;Hurley J.P.;Cahan A.;Gilon D.;Israel S.;Abella H.R.;Korem M.;Durante-Mangoni E.;Mattucci I.;Pinto D.;Agrusta F.;Senese A.;Ragone E.;Utili R.;Cecchi E.;De Rosa F.;Roda J.R.;Forno D.;Imazio M.;Trinchero R.;Grossi P.;Lattanzio M.;Toniolo A.;Goglio A.;Raglio A.;Ravasio V.;Rizzi M.;Lopez R.A.;Suter F.;Carosi G.;Magri S.;Signorini L.;Kanafani Z.;Kanj S.S.;Sharif-Yakan A.;Abidin I.;Tamin S.S.;Martinez E.R.;Pinilla B.;Nieto G.I.S.;Van Der Meer J.T.M.;Chambers S.;Holland D.;Morris A.;Raymond N.;Read K.;Murdoch D.R.;Dragulescu S.;Ionac A.;Pinto A.;Mornos C.;Butkevich O.M.;Chipigina N.;Kirill O.;Vadim K.;Vinogradova T.;Edathodu J.;Halim M.;Liew Y.-Y.;Tan R.-S.;Valerio M.;Lejko-Zupanc T.;Logar M.;Mueller-Premru M.;Commerford P.;Commerford A.;Deetlefs E.;Hansa C.;Ntsekhe M.;Almela M.;Armero Y.;Vazquez P.;Azqueta M.;Castaneda X.;Cervera C.;Falces C.;Garcia-De-La-Maria C.;Fita G.;Gatell J.M.;Heras M.;Verde E.;Almirante B.;De Alarcon A.;Parra R.;Alestig E.;Johansson M.;Olaison L.;Snygg-Martin U.;Pachirat O.;Pachirat P.;Pussadhamma B.;Senthong V.;Casey A.;Elliott T.;Lambert P.;Watkin R.;Eyton C.;Klein J.L.;Kauffman C.;Bedimo R.;Corey G.R.;Crowley A.L.;Douglas P.;Drew L.;Fowler V.G.;Holland T.;Lalani T.;Mudrick D.;Samad Z.;Sexton D.;Stryjewski M.;Wang A.;Woods C.W.;Lerakis S.;Cantey R.;Steed L.;Wray D.;Dickerman S.A.;Bonilla H.;DiPersio J.;Salstrom S.-J.;Baddley J.;Patel M.;Peterson G.;Stancoven A.;Levine D.;Riddle J.;Rybak M.;Cabell C.H.;Baloch K.;Dixon C.C.;Harding T.;Jones-Richmond M.;Park L.P.;Sanderford B.;Stafford J.;Anstrom K.;Karchmer A.W.;Sexton D.J.;Durack D.T.;Eykyn S.;Moreillon P.;Sexton. D.J.;Arnold C.J.;Johnson M.;Bayer A.S.;Bradley S.;Giannitsioti E.;Miro J.M.;Tornos P. | Institution: | (Arnold, Johnson, Chu, Corey, Crowley, Douglas, Drew, Fowler, Holland, Lalani, Mudrick, Samad, Sexton, Stryjewski, Wang, Woods) Duke University, Medical Center, Durham, NC, United States (Bayer) Harbor-UCLA, Medical Center, Los Angeles, CA, United States (Bradley) VA Ann Arbor Healthcare System, University of Michigan, Ann Arbor, MI, United States (Giannitsioti, Helen, Sofia, Ioannis, Thomas) Attikon University, General Hospital, Athens, Greece (Miro, Almela, Armero, Azqueta, Castaneda, Cervera, Falces, Garcia-De-La-Maria, Fita, Gatell, Heras, Llopis, Marco, Mestres, Moreno, Ninot, Pare, Pericas, Ramirez, Rovira, Sitges) Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain (Tornos, Fernandez-Hidalgo, Almirante) Hospital Universitari Vall d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain (Tattevin, Donal, Donnio, Flecher, Michelet, Revest) Pontchaillou University, Rennes, France (Strahilevitz, Cahan, Gilon, Israel, Korem) Hadassah-Hebrew University, Jerusalem, Israel (Spelman) Alfred Hospital, Monash University, Melbourne, VIC, Australia (Athan, Harris) Barwon Health, Geelong, VIC, Australia (Nacinovich, Oses, Ronderos, Sucari, Thierer) Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina (Fortes, Fortes) Hospital Universitario Clementino Fraga Filho, UFRJ, Rio de Janeiro, Brazil (Lamas, Weksler, Ferraiuoli, Golebiovski) Instituto Nacional de Cardiologia and Unigranrio, Rio de Janeiro, Brazil (Barsic, Bukovski, Krajinovic, Pangercic, Rudez, Vincelj) University Hospital for Infectious Diseases, Zagreb, Croatia (Munoz, Bermejo, Bouza, Leoni, Robles, Ramallo, Cruz, Kestler, Marin, Selles, Abella, Roda, Lopez, Pinilla, Pinto, Valerio, Vazquez, Verde) Hospital General Universitario Gregorio Maranon, Madrid, Spain (Clara, Sanchez) Hospital Italiano, Argentina (Casabe, Cortes) Hospital Universitario, Fundacion Favaloro, Argentina (Altclas, Kogan) Sanatorio de la Trinidad Mitre, Argentina (Kennedy, Tan) Canberra Hospital, Australia (Gordon, Papanicolas) Flinders Medical Centre, Australia (Korman, Kotsanas) Southern Health, Australia (Dever, Jones, Konecny, Lawrence, Rees, Ryan) St. George Hospital, Australia (Jones, Ryan, Feneley, Harkness) St. Vincent's, Australia (Jones, Ryan) Sutherland, Australia (Jones, Ryan, Post, Reinbott) University of New South Wales, Australia (Gattringer, Wiesbauer) Vienna General Hospital, Austria (Andrade, De Brito, Guimaraes) Ana Neri Hospital, Brazil (Grinberg, Mansur, Siciliano, Strabelli, Vieira) Heart Institute (Incor), University of Sao Paulo, Medical School, Brazil (De Medeiros Tranchesi, Paiva) Hospital 9 de Julho, Brazil (De Oliveira Ramos) Instituto Dante Pazzanese de Cardiologia, Brazil (Karlowsky, Keynan, Morris, Rubinstein) University of Manitoba, Canada (Jones, Garcia) Hospital Clinico, Pont. Universidad Catolica de Chile, Chile (Cereceda, Fica, Mella) Hospital Clinico, Universidad de Chile, Chile (Fernandez, Franco, Gonzalez, Jaramillo) Clinica Cardiovascular Medellin, Colombia (Freiberger) Ceitec, Masaryk University, Brno, Czech Republic (Pol, Zaloudikova) Centre for Cardiovascular Surgery and Transplantation, Czech Republic (Ashour, Kholy, Mishaal, Osama, Rizk) Cairo University, Medical School, Egypt (Aissa, Alauzet, Alla, Campagnac, Doco-Lecompte, Selton-Suty) CHU Nancy-Brabois, France (Casalta, Fournier, Habib, Raoult, Thuny) Faculte de Medecine de Marseille, France (Delahaye, Delahaye, Vandenesch) Hospital Louis Pradel, France (Chevalier, Jeu, Remadi, Rusinaru, Tribouilloy) South Hospital Amiens, France (Bernard, Chirouze, Hoen, Leroy, Plesiat) University Medical Center of Besancon, France (Naber, Neuerburg) Universitaetskliniken Bergmannsheil Bochum, Germany (Naber, Neuerburg, Mazaheri) University Essen, Germany (Mylona, Paniara, Papanicolaou, Pyros, Skoutelis) Evangelismos General Hospital of Athens, Greece (Sharma) All India Institute of Medical Sciences, India (Francis, Nair, Thomas, Venugopal) Medical College Calicut, India (Hannan, Hurley) Mater Hospitals, Ireland (Strahilevitz, Rubinstein) Tel Aviv University, School of Medicine, Israel (Durante-Mangoni, Mattucci, Pinto, Agrusta, Senese, Ragone, Utili) II Universita di Napoli, Italy (Cecchi, De Rosa, Forno, Imazio, Trinchero) Maria Vittoria Hospital, Italy (Grossi, Lattanzio, Toniolo) Ospedale di Circolo Varese, Italy (Goglio, Raglio, Ravasio, Rizzi, Suter) Ospedali Riuniti di Bergamo, Italy (Carosi, Magri, Signorini) Spedali Civili, Universita di Brescia, Italy (Kanafani, Kanj, Sharif-Yakan) American University of Beirut, Medical Center, Lebanon (Abidin) University of Malaya, Medical Center, Malaysia (Tamin) National Heart Institute, Malaysia (Martinez, Nieto) Instituto Nacional de Cardiologia Ignacio Chavez, Mexico (Van Der Meer) University of Amsterdam, Netherlands (Chambers, Murdoch) University of Otago, New Zealand (Holland) Middlemore Hospital, New Zealand (Morris) Diagnostic Medlab, New Zealand (Raymond) Wellington Hospital, New Zealand (Read) North Shore Hospital, New Zealand (Dragulescu, Ionac, Mornos) Victor Babes University of Medicine and Pharmacy, Romania (Butkevich) Learning-Scientific Centre, Medical Centre of Russian Presidential Affairs, Government Medical Centre of Russian, Russian Federation (Chipigina, Kirill, Vadim, Vinogradova) Russian Medical State University, Russian Federation (Edathodu, Halim) King Faisal Specialist Hospital, Research Center, Saudi Arabia (Liew, Tan) National Heart Centre, Singapore (Lejko-Zupanc, Logar, Mueller-Premru) Medical Center Ljublijana, Slovenia (Commerford, Commerford, Deetlefs, Hansa, Ntsekhe) University of Cape Town, Groote Schuur Hospital, South Africa (Anguera, Font, Guma) Hospital de Sabadell, Spain (De Alarcon, Parra) Hospital Universitario Virgen del Rocio, Spain (Alestig, Johansson, Olaison, Snygg-Martin) Sahlgrenska Universitetssjukhuset/Ostra, Sweden (Pachirat, Pachirat, Pussadhamma, Senthong) Khon Kaen University, Thailand (Casey, Elliott, Lambert, Watkin) Queen Elizabeth Hospital, United Kingdom (Eyton, Klein) St. Thomas' Hospital, United Kingdom (Bradley, Kauffman) Ann Arbor VA Medical Center, United States (Bedimo) Dallas VA Medical Center, United States (Lerakis) Emory University, United States (Cantey, Steed, Wray) Medical University of South Carolina, United States (Dickerman) New York University, Medical Center, United States (Bonilla, DiPersio, Salstrom) Summa Health System, United States (Baddley, Patel) University of Alabama at Birmingham, United States (Peterson, Stancoven) UT-Southwestern Medical Center, United States (Levine, Riddle, Rybak) Wayne State University, United States (Cabell) Quintiles, United States (Chu, Corey, Fowler, Baloch, Dixon, Harding, Jones-Richmond, Park, Sanderford, Stafford) ICE Coordinating Center, United States (Bayer, Miro, Athan, Chu, Hoen, Murdoch, Corey, Fowler, Wang, Cabell, Anstrom, Karchmer, Sexton) ICE Publications Committee, United States (Bayer, Miro, Chu, Rubinstein, Raoult, Hoen, Olaison, Corey, Fowler, Cabell, Durack, Eykyn, Moreillon, Sexton.) ICE Steering Committee, United States | Issue Date: | 25-May-2015 | Copyright year: | 2015 | Publisher: | American Society for Microbiology (E-mail: Journals@asmusa.org) | Place of publication: | United States | Publication information: | Antimicrobial Agents and Chemotherapy. 59 (4) (pp 2365-2373), 2015. Date of Publication: 01 Apr 2015. | Journal: | Antimicrobial Agents and Chemotherapy | Abstract: | Candida infective endocarditis is a rare disease with a high mortality rate. Our understanding of this infection is derived from case series, case reports, and small prospective cohorts. The purpose of this study was to evaluate the clinical features and use of different antifungal treatment regimens for Candida infective endocarditis. This prospective cohort study was based on 70 cases of Candida infective endocarditis from the International Collaboration on Endocarditis (ICE)-Prospective Cohort Study and ICE-Plus databases collected between 2000 and 2010. The majority of infections were acquired nosocomially (67%). Congestive heart failure (24%), prosthetic heart valve (46%), and previous infective endocarditis (26%) were common comorbidities. Overall mortality was high, with 36% mortality in the hospital and 59% at 1 year. On univariate analysis, older age, heart failure at baseline, persistent candidemia, nosocomial acquisition, heart failure as a complication, and intracardiac abscess were associated with higher mortality. Mortality was not affected by use of surgical therapy or choice of antifungal agent. A subgroup analysis was performed on 33 patients for whom specific antifungal therapy information was available. In this subgroup, 11 patients received amphotericin B-based therapy and 14 received echinocandin-based therapy. Despite a higher percentage of older patients and nosocomial infection in the echinocandin group, mortality rates were similar between the two groups. In conclusion, Candida infective endocarditis is associated with a high mortality rate that was not impacted by choice of antifungal therapy or by adjunctive surgical intervention. Additionally, echinocandin therapy was as effective as amphotericin B-based therapy in the small subgroup analysis.Copyright © 2015, American Society for Microbiology. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1128/AAC.04867-14 | PubMed URL: | 25645855 [http://www.ncbi.nlm.nih.gov/pubmed/?term=25645855] | ISSN: | 0066-4804 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/40751 | Type: | Article | Subjects: | priority journal Pichia kudriavzevii observational study mycotic aneurysm/co [Complication] male major clinical study human hospital infection heart valve prosthesis heart failure heart abscess/co [Complication] follow up female congestive heart failure/co [Complication] candidemia micafungin/dt [Drug Therapy] flucytosine/dt [Drug Therapy] fluconazole/dt [Drug Therapy] echinocandin/dt [Drug Therapy] caspofungin/dt [Drug Therapy] antifungal agent/dt [Drug Therapy] anidulafungin/dt [Drug Therapy] amphotericin B lipid complex/dt [Drug Therapy] amphotericin B deoxycholate/dt [Drug Therapy] amphotericin B cholesterol sulfate/dt [Drug Therapy] amphotericin B/dt [Drug Therapy] prospective study bacterial endocarditis Candida albicans *Candida endocarditis/dt [Drug Therapy] Candida endocarditis/dt [Drug Therapy] Candida glabrata Candida parapsilosis Candida tropicalis cerebrovascular accident/co [Complication] cohort analysis aged article *Candida endocarditis / *drug therapy Candida endocarditis / drug therapy aged Article bacterial endocarditis Candida albicans prospective study priority journal Pichia kudriavzevii observational study mycotic aneurysm / complication male major clinical study human hospital infection heart valve prosthesis heart failure heart abscess / complication follow up female congestive heart failure / complication cohort analysis cerebrovascular accident / complication candidemia Candida tropicalis Candida parapsilosis Candida glabrata |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional or survey) |
Appears in Collections: | Articles |
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