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Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/40934
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dc.contributor.authorChen J.en
dc.contributor.authorForbes J.M.en
dc.contributor.authorBeare R.en
dc.contributor.authorBlizzard L.en
dc.contributor.authorVenn A.J.en
dc.contributor.authorPhan T.G.en
dc.contributor.authorSrikanth V.en
dc.contributor.authorMoran C.en
dc.contributor.authorMunch G.en
dc.date.accessioned2021-05-14T14:00:41Zen
dc.date.available2021-05-14T14:00:41Zen
dc.date.copyright2015en
dc.date.created20150114en
dc.date.issued2015-01-14en
dc.identifier.citationDiabetes. 64 (1) (pp 279-283), 2015. Date of Publication: 01 Jan 2015.en
dc.identifier.issn0012-1797en
dc.identifier.urihttps://repository.monashhealth.org/monashhealthjspui/handle/1/40934en
dc.description.abstractType 2 diabetes mellitus (T2DM) is associated with brain atrophy, but the mechanisms underlying this link are unknown. Advanced glycation end products (AGEs) accumulate in T2DM, resulting in inflammation, oxidative stress, and protein cross-linking, which are known contributors to neurodegeneration. We aimed to study whether tissue AGE accumulation is associated with T2DM-related brain atrophy. We performed brain magnetic resonance imaging, cognitive tests, and noninvasive skin autofluorescence (SAF; a measure of tissue AGE levels) on people aged >55 years with and without T2DM. Multivariable linear regression was used to study the relationships among T2DM, SAF, and gray matter volume (GMV). There were 486 people included in the study. T2DM was associated with greater SAF. Greater SAF, T2DM, and cognitive impairment were each associated with lower GMV independently of age, sex, and total intracranial volume. SAF partially mediated the association between T2DM and GMV. Longitudinal studies may help confirm whether tissue AGE accumulation is associated with brain atrophy in T2DM.Copyright © 2015 by the American Diabetes Association.en
dc.languageenen
dc.languageEnglishen
dc.publisherAmerican Diabetes Association Inc. (E-mail: membership@diabetes.org)en
dc.relation.ispartofDiabetesen
dc.titleType 2 diabetes, skin autofluorescence, and brain atrophy.en
dc.typeArticleen
dc.identifier.doihttp://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2337/db14-0506en
dc.publisher.placeUnited Statesen
dc.identifier.pubmedid25053588 [http://www.ncbi.nlm.nih.gov/pubmed/?term=25053588]en
dc.identifier.source601089341en
dc.identifier.institution(Moran, Beare, Phan, Chen, Srikanth) Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Melbourne, VIC, Australia (Moran, Beare, Phan, Chen, Srikanth) Neurosciences, Monash Medical Centre, Monash Health, Melbourne, Australia (Munch) Department of Pharmacology, School of Medicine, University of Western Sydney, Sydney, NSW, Australia (Munch) Molecular Medicine Research Group, University of Western Sydney, Sydney, NSW, Australia (Forbes) Translational Research Institute, Mater University of Queensland, Brisbane, QLD, Australia (Forbes) Mater Clinical School, University of Queensland, Brisbane, QLD, Australia (Beare, Chen) Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia (Blizzard, Venn, Srikanth) Menzies Research Institute Tasmania, Hobart, TAS, Australiaen
dc.description.addressV. Srikanth, Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Melbourne, VIC, Australiaen
dc.description.publicationstatusEmbaseen
dc.rights.statementCopyright 2015 Elsevier B.V., All rights reserved.en
dc.identifier.authoremailSrikanth V.; velandai.srikanth@monash.eduen
dc.description.grantNo: 403000 Organization: (NHMRC) *National Health and Medical Research Council* No: 436797 Organization: (NHMRC) *National Health and Medical Research Council* Organization: (NHMRC) *National Health and Medical Research Council*en
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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