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https://repository.monashhealth.org/monashhealthjspui/handle/1/40934| Title: | Type 2 diabetes, skin autofluorescence, and brain atrophy. | Authors: | Chen J.;Forbes J.M.;Beare R.;Blizzard L.;Venn A.J.;Phan T.G.;Srikanth V.;Moran C.;Munch G. | Institution: | (Moran, Beare, Phan, Chen, Srikanth) Stroke and Ageing Research Group, Department of Medicine, Southern Clinical School, Melbourne, VIC, Australia (Moran, Beare, Phan, Chen, Srikanth) Neurosciences, Monash Medical Centre, Monash Health, Melbourne, Australia (Munch) Department of Pharmacology, School of Medicine, University of Western Sydney, Sydney, NSW, Australia (Munch) Molecular Medicine Research Group, University of Western Sydney, Sydney, NSW, Australia (Forbes) Translational Research Institute, Mater University of Queensland, Brisbane, QLD, Australia (Forbes) Mater Clinical School, University of Queensland, Brisbane, QLD, Australia (Beare, Chen) Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia (Blizzard, Venn, Srikanth) Menzies Research Institute Tasmania, Hobart, TAS, Australia | Issue Date: | 14-Jan-2015 | Copyright year: | 2015 | Publisher: | American Diabetes Association Inc. (E-mail: membership@diabetes.org) | Place of publication: | United States | Publication information: | Diabetes. 64 (1) (pp 279-283), 2015. Date of Publication: 01 Jan 2015. | Journal: | Diabetes | Abstract: | Type 2 diabetes mellitus (T2DM) is associated with brain atrophy, but the mechanisms underlying this link are unknown. Advanced glycation end products (AGEs) accumulate in T2DM, resulting in inflammation, oxidative stress, and protein cross-linking, which are known contributors to neurodegeneration. We aimed to study whether tissue AGE accumulation is associated with T2DM-related brain atrophy. We performed brain magnetic resonance imaging, cognitive tests, and noninvasive skin autofluorescence (SAF; a measure of tissue AGE levels) on people aged >55 years with and without T2DM. Multivariable linear regression was used to study the relationships among T2DM, SAF, and gray matter volume (GMV). There were 486 people included in the study. T2DM was associated with greater SAF. Greater SAF, T2DM, and cognitive impairment were each associated with lower GMV independently of age, sex, and total intracranial volume. SAF partially mediated the association between T2DM and GMV. Longitudinal studies may help confirm whether tissue AGE accumulation is associated with brain atrophy in T2DM.Copyright © 2015 by the American Diabetes Association. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2337/db14-0506 | PubMed URL: | 25053588 [http://www.ncbi.nlm.nih.gov/pubmed/?term=25053588] | ISSN: | 0012-1797 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/40934 | Type: | Article |
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