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https://repository.monashhealth.org/monashhealthjspui/handle/1/40983| Title: | Inflammatory and other biomarkers: Role in pathophysiology and prediction of gestational diabetes mellitus. | Authors: | De Courten B. ;Abell S.K.;Teede H.J. ;Boyle J.A. | Institution: | (Abell, De Courten, Boyle, Teede) Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Clayton 3168, Australia (Abell, De Courten, Boyle, Teede) Diabetes and Vascular Medicine Unit, Monash Health, Clayton 3168, Australia (Boyle) Monash Women's Services, Monash Health, Clayton 3168, Australia | Issue Date: | 29-Jun-2015 | Copyright year: | 2015 | Publisher: | MDPI AG (Postfach, Basel CH-4005, Switzerland) | Place of publication: | Switzerland | Publication information: | International Journal of Molecular Sciences. 16 (6) (pp 13442-13473), 2015. Date of Publication: 11 Jun 2015. | Journal: | International Journal of Molecular Sciences | Abstract: | Understanding pathophysiology and identifying mothers at risk of major pregnancy complications is vital to effective prevention and optimal management. However, in current antenatal care, understanding of pathophysiology of complications is limited. In gestational diabetes mellitus (GDM), risk prediction is mostly based on maternal history and clinical risk factors and may not optimally identify high risk pregnancies. Hence, universal screening is widely recommended. Here, we will explore the literature on GDM and biomarkers including inflammatory markers, adipokines, endothelial function and lipids to advance understanding of pathophysiology and explore risk prediction, with a goal to guide prevention and treatment of GDM.Copyright © 2015, MDPI AG. All rights Reserved. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.3390/ijms160613442 | PubMed URL: | 26110385 [http://www.ncbi.nlm.nih.gov/pubmed/?term=26110385] | ISSN: | 1661-6596 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/40983 | Type: | Review | Subjects: | matrix metalloproteinase/ec [Endogenous Compound] tumor necrosis factor alpha/ec [Endogenous Compound] vitamin D insulin resistance lipid metabolism macrophage meta analysis (topic) metabolomics non insulin dependent diabetes mellitus/et [Etiology] obesity pathophysiology *pregnancy diabetes mellitus/et [Etiology] randomized controlled trial (topic) review systematic review (topic) adipocytokine/ec [Endogenous Compound] adiponectin/ec [Endogenous Compound] C reactive protein/ec [Endogenous Compound] calcifediol/ct [Clinical Trial] calcium/ct [Clinical Trial] cytokine/ec [Endogenous Compound] fatty acid binding protein 4/ec [Endogenous Compound] growth factor/ec [Endogenous Compound] I kappa B kinase/ec [Endogenous Compound] immunoglobulin enhancer binding protein/ec [Endogenous Compound] interleukin 6/ec [Endogenous Compound] leptin/ec [Endogenous Compound] nicotinamide phosphoribosyltransferase/ec [Endogenous Compound] resistin/ec [Endogenous Compound] retinol binding protein 4/ec [Endogenous Compound] stress activated protein kinase/ec [Endogenous Compound] toll like receptor/ec [Endogenous Compound] dyslipidemia human *inflammation human systematic review (topic) Review randomized controlled trial (topic) *pregnancy diabetes mellitus / *etiology dyslipidemia obesity non insulin dependent diabetes mellitus / etiology metabolomics macrophage pathophysiology lipid metabolism insulin resistance *inflammation meta analysis (topic) |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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