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Title: | Metabolic factors in diffuse idiopathic skeletal hyperostosis - A review of clinical data. | Authors: | Pillai S.;Littlejohn G. | Institution: | (Pillai, Littlejohn) Departments of Rheumatology and Medicine, Monash Health and Monash University, 246 Clayton Road, Clayton, VIC 3168, Australia | Issue Date: | 15-May-2015 | Copyright year: | 2014 | Publisher: | Bentham Science Publishers B.V. (P.O. Box 294, Bussum 1400 AG, Netherlands) | Place of publication: | Netherlands | Publication information: | Open Rheumatology Journal. 8 (1) (pp 116-128), 2014. Date of Publication: 2014. | Journal: | Open Rheumatology Journal | Abstract: | Objectives: We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH. Method(s): We identified studies in our personal database and PubMed using the following keywords in various combinations: "diffuse idiopathic skeletal hyperostosis", "ankylosing hyperostosis", "Forestier's disease", "diabetes", "insulin", "obesity", "metabolic", "growth factors", "adipokines", "glucose tolerance" and "chondrocytes". Result(s): We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH. Conclusion(s): Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed.Copyright © Pillai and Littlejohn; LicenseeBentham Open. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.2174/1874312901408010116 | ISSN: | 1874-3129 (electronic) | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/41620 | Type: | Article | Subjects: | osteoarthritis osteophyte beta catenin/ec [Endogenous Compound] bone derived growth factor/ec [Endogenous Compound] bone morphogenetic protein/ec [Endogenous Compound] bone morphogenetic protein 2/ec [Endogenous Compound] endothelin 1/ec [Endogenous Compound] glucose/ec [Endogenous Compound] growth factor/ec [Endogenous Compound] immunoglobulin enhancer binding protein/ec [Endogenous Compound] insulin/ec [Endogenous Compound] leptin/ec [Endogenous Compound] prostacyclin/ec [Endogenous Compound] retinol somatomedin/ec [Endogenous Compound] somatomedin C/ec [Endogenous Compound] transforming growth factor beta1/ec [Endogenous Compound] Wnt protein/ec [Endogenous Compound] priority journal *ankylosing hyperostosis article bone growth bone metabolism dietary intake glucose intolerance human hyperglycemia hyperinsulinemia hyperostosis metabolic syndrome X non insulin dependent diabetes mellitus obesity ossification hyperostosis metabolic syndrome X non insulin dependent diabetes mellitus obesity ossification osteoarthritis osteophyte *ankylosing hyperostosis Article bone growth bone metabolism dietary intake glucose intolerance human hyperglycemia hyperinsulinemia priority journal |
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