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Title: | Functional magnetic resonance imaging of working memory in Huntington's disease: Cross-sectional data from the IMAGE-HD study. | Authors: | Poudel G.;Dominguez D. J.F.;Carron S.P.;Ando A.;Churchyard A.;Chua P.;Bohanna I.;Dymowski A.R.;Georgiou-Karistianis N. ;Egan G.F.;Stout J.C. | Institution: | (Georgiou-Karistianis, Stout, Dominguez D., Carron, Ando, Chua, Dymowski, Poudel) School of Psychology and Psychiatry, Monash University, Clayton, VIC, Australia (Ando, Dymowski) Howard Florey Institute, Florey Neuroscience Institutes, Parkville, VIC, Australia (Churchyard, Egan) Department of Neurology, Monash Medical Centre, Clayton, VIC, Australia (Bohanna, Egan) Centre for Neuroscience, University of Melbourne, Parkville, VIC, Australia (Poudel, Egan) Monash Biomedical Imaging (MBI), Monash University, Clayton, VIC, Australia (Poudel, Egan) VLSCI's Life Sciences Computation Centre, Melbourne, VIC, Australia | Issue Date: | 22-Apr-2014 | Copyright year: | 2014 | Publisher: | John Wiley and Sons Inc. (P.O.Box 18667, Newark NJ 07191-8667, United States) | Place of publication: | United States | Publication information: | Human Brain Mapping. 35 (5) (pp 1847-1864), 2014. Date of Publication: May 2014. | Journal: | Human Brain Mapping | Abstract: | We used functional magnetic resonance imaging (fMRI) to investigate spatial working memory (WM) in an N-BACK task (0, 1, and 2-BACK) in premanifest Huntington's disease (pre-HD, n = 35), early symptomatic Huntington's disease (symp-HD, n = 23), and control (n = 32) individuals. Overall, both WM conditions (1-BACK and 2-BACK) activated a large network of regions throughout the brain, common to all groups. However, voxel-wise and time-course analyses revealed significant functional group differences, despite no significant behavioral performance differences. During 1-BACK, voxel-wise blood-oxygen-level-dependent (BOLD) signal activity was significantly reduced in a number of regions from the WM network (inferior frontal gyrus, anterior insula, caudate, putamen, and cerebellum) in pre-HD and symp-HD groups, compared with controls; however, time-course analysis of the BOLD response in the dorsolateral prefrontal cortex (DLPFC) showed increased activation in symp-HD, compared with pre-HD and controls. The pattern of reduced voxel-wise BOLD activity in pre-HD and symp-HD, relative to controls, became more pervasive during 2-BACK affecting the same structures as in 1-BACK, but also incorporated further WM regions (anterior cingulate gyrus, parietal lobe and thalamus). The DLPFC BOLD time-course for 2-BACK showed a reversed pattern to that observed in 1-BACK, with a significantly diminished signal in symp-HD, relative to pre-HD and controls. Our findings provide support for functional brain reorganisation in cortical and subcortical regions in both pre-HD and symp-HD, which are modulated by task difficulty. Moreover, the lack of a robust striatal BOLD signal in pre-HD may represent a very early signature of change observed up to 15 years prior to clinical diagnosis. © 2013 Wiley Periodicals, Inc. | DOI: | http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1002/hbm.22296 | Link to associated publication: | Click here for full text options | PubMed URL: | 23913754 [http://www.ncbi.nlm.nih.gov/pubmed/?term=23913754] | ISSN: | 1065-9471 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/41936 | Type: | Article | Subjects: | nerve potential nuclear magnetic resonance scanner occipital cortex orbital cortex parietal cortex postcentral gyrus posterior cingulate posterior insula prefrontal cortex primary motor cortex priority journal putamen response time stimulus supramarginal gyrus thalamus *working memory functional group male accuracy adult aged anterior cingulate anterior insula article BOLD signal caudate nucleus cerebellum controlled study dynamics female frontal operculum *functional magnetic resonance imaging globus pallidus human *Huntington chorea inferior frontal gyrus information processing intelligence quotient lingual gyrus major clinical study middle temporal gyrus dynamics female frontal operculum *functional magnetic resonance imaging globus pallidus human *Huntington chorea inferior frontal gyrus information processing intelligence quotient lingual gyrus major clinical study male middle temporal gyrus nerve potential nuclear magnetic resonance scanner occipital cortex orbital cortex parietal cortex postcentral gyrus posterior cingulate posterior insula prefrontal cortex primary motor cortex adult putamen response time stimulus supramarginal gyrus thalamus *working memory accuracy priority journal aged anterior cingulate anterior insula article BOLD signal caudate nucleus cerebellum controlled study |
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