CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.

Johnson N.; Maguire S.; Morra A.; Kapoor P.M.; Tomczyk K.; Jones M.E.; Schoemaker M.J.; Gilham C.; Bolla M.K.; Wang Q.; Dennis J.; Ahearn T.U.; Andrulis I.L.; Anton-Culver H.; Antonenkova N.N.; Arndt V.; Aronson K.J.; Augustinsson A.; Baynes C.; Freeman L.E.B.; Beckmann M.W.; Benitez J.; Bermisheva M.; Blomqvist C.; Boeckx B.; Bogdanova N.V.; Bojesen S.E.; Brauch H.; Brenner H.; Burwinkel B.; Campa D.; Canzian F.; Castelao J.E.; Chanock S.J.; Chenevix-Trench G.; Clarke C.L.; Borresen-Dale A.-L.; Alnaes G.I.G.; Sahlberg K.K.; Ottestad L.; Karesen R.; Schlichting E.; Holmen M.M.; Sauer T.; Haakensen V.; Engebraten O.; Naume B.; Fossa A.; Kiserud C.E.; Reinertsen K.V.; Helland A.; Riis M.; Geisler J.; Conroy D.M.; Couch F.J.; Cox A.; Cross S.S.; Czene K.; Dork T.; Eliassen A.H.; Engel C.; Evans D.G.; Fasching P.A.; Figueroa J.; Floris G.; Flyger H.; Gago-Dominguez M.; Gapstur S.M.; Garcia-Closas M.; Gaudet M.M.; Giles G.G.; Goldberg M.S.; Gonzalez-Neira A.; Bowtell D.D.L.; Webb P.M.; Guenel P.; Hahnen E.; Haiman C.A.; Hakansson N.; Hall P.; Hamann U.; Harrington P.A.; Hart S.N.; Hooning M.J.; Hopper J.L.; Howell A.; Hunter D.J.; Clarke C.; Scott R.; Baxter R.; Yip D.; Carpenter J.; Davis A.; Pathmanathan N.; Graham D.; Sachchithananthan M.; Amor D.; Andrews L.; Antill Y.; Balleine R.; Beesley J.; Bennett I.; Bogwitz M.; Botes L.; Brennan M.; Brown M.; Buckley M.; Burke J.; Butow P.; Caldon L.; Campbell I.; Chauhan D.; Chauhan M.; Christian A.; Cohen P.; Colley A.; Crook A.; Cui J.; Cummings M.; Dawson S.-J.; DeFazio A.; Delatycki M.; Dickson R.; Dixon J.; Edkins T.; Edwards S.; Farshid G.; Fellows A.; Fenton G.; Field M.; Flanagan J.; Fong P.; Forrest L.; Fox S.; French J.; Friedlander M.; Gaff C.; Gattas M.; George P.; Greening S.; Harris M.; Hart S.; Hayward N.; Hopper J.; Hoskins C.; Hunt C.; James P.; Jenkins M.; Kidd A.; Kirk J.; Koehler J.; Kollias J.; Lakhani S.; Lawrence M.; Lindeman G.; Lipton L.; Lobb L.; Mann G.; Marsh D.; McLachlan S.A.; Meiser B.; Milne R.L.; Nightingale S.; O'Connell S.; O'Sullivan S.; Ortega D.G.; Pachter N.; Patterson B.; Pearn A.; Phillips K.; Pieper E.; Rickard E.; Robinson B.; Saleh M.; Salisbury E.; Saunders C.; Saunus J.; Sexton A.; Shelling A.; Simpson P.; Southey M.C.; Spurdle A.; Taylor J.; Taylor R.; Thorne H.; Trainer A.; Tucker K.; Visvader J.; Walker L.; Williams R.; Winship I.; Young M.A.; Jager A.; Jakubowska A.; John E.M.; Keeman R.; Khusnutdinova E.; Kitahara C.M.; Kosma V.-M.; Koutros S.; Kraft P.; Kristensen V.N.; Kurian A.W.; Lambrechts D.; Le Marchand L.; Linet M.; Lubinski J.; Mannermaa A.; Manoukian S.; Margolin S.; Martens J.W.M.; Mavroudis D.; Mayes R.; Meindl A.; Neuhausen S.L.; Nevanlinna H.; Newman W.G.; Nielsen S.F.; Nordestgaard B.G.; Obi N.; Olshan A.F.; Olson J.E.; Olsson H.; Orban E.; Park-Simon T.-W.; Peterlongo P.; Plaseska-Karanfilska D.; Pylkas K.; Rennert G.; Rennert H.S.; Ruddy K.J.; Saloustros E.; Sandler D.P.; Sawyer E.J.; Schmutzler R.K.; Scott C.; Shu X.-O.; Simard J.; Smichkoska S.; Sohn C.; Spinelli J.J.; Stone J.; Tamimi R.M.; Taylor J.A.; Tollenaar R.A.E.M.; Tomlinson I.; Troester M.A.; Truong T.; Vachon C.M.; van Veen E.M.; Wang S.S.; Weinberg C.R.; Wendt C.; Wildiers H.; Winqvist R.; Wolk A.; Zheng W.; Ziogas A.; Dunning A.M.; Pharoah P.D.P.; Easton D.F.; Howie A.F.; Peto J.; dos-Santos-Silva I.; Swerdlow A.J.; Chang-Claude J.; Schmidt M.K.; Orr N.; Fletcher O.

Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/43128

Title:	*CYP3A71C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.**
Authors:	Johnson N.;Maguire S.;Morra A.;Kapoor P.M.;Tomczyk K.;Jones M.E.;Schoemaker M.J.;Gilham C.;Bolla M.K.;Wang Q.;Dennis J.;Ahearn T.U.;Andrulis I.L.;Anton-Culver H.;Antonenkova N.N.;Arndt V.;Aronson K.J.;Augustinsson A.;Baynes C.;Freeman L.E.B.;Beckmann M.W.;Benitez J.;Bermisheva M.;Blomqvist C.;Boeckx B.;Bogdanova N.V.;Bojesen S.E.;Brauch H.;Brenner H.;Burwinkel B.;Campa D.;Canzian F.;Castelao J.E.;Chanock S.J.;Chenevix-Trench G.;Clarke C.L.;Borresen-Dale A.-L.;Alnaes G.I.G.;Sahlberg K.K.;Ottestad L.;Karesen R.;Schlichting E.;Holmen M.M.;Sauer T.;Haakensen V.;Engebraten O.;Naume B.;Fossa A.;Kiserud C.E.;Reinertsen K.V.;Helland A.;Riis M.;Geisler J.;Conroy D.M.;Couch F.J.;Cox A.;Cross S.S.;Czene K.;Dork T.;Eliassen A.H.;Engel C.;Evans D.G.;Fasching P.A.;Figueroa J.;Floris G.;Flyger H.;Gago-Dominguez M.;Gapstur S.M.;Garcia-Closas M.;Gaudet M.M.;Giles G.G.;Goldberg M.S.;Gonzalez-Neira A.;Bowtell D.D.L.;Webb P.M.;Guenel P.;Hahnen E.;Haiman C.A.;Hakansson N.;Hall P.;Hamann U.;Harrington P.A.;Hart S.N.;Hooning M.J.;Hopper J.L.;Howell A.;Hunter D.J.;Clarke C.;Scott R.;Baxter R.;Yip D.;Carpenter J.;Davis A. ;Pathmanathan N.;Graham D.;Sachchithananthan M.;Amor D.;Andrews L.;Antill Y.;Balleine R.;Beesley J.;Bennett I.;Bogwitz M.;Botes L.;Brennan M.;Brown M.;Buckley M.;Burke J.;Butow P.;Caldon L.;Campbell I.;Chauhan D.;Chauhan M.;Christian A.;Cohen P.;Colley A.;Crook A.;Cui J.;Cummings M.;Dawson S.-J.;DeFazio A.;Delatycki M.;Dickson R.;Dixon J.;Edkins T.;Edwards S.;Farshid G.;Fellows A.;Fenton G.;Field M.;Flanagan J.;Fong P.;Forrest L.;Fox S.;French J.;Friedlander M.;Gaff C.;Gattas M.;George P.;Greening S.;Harris M. ;Hart S.;Hayward N.;Hopper J.;Hoskins C.;Hunt C.;James P.;Jenkins M.;Kidd A.;Kirk J.;Koehler J.;Kollias J.;Lakhani S.;Lawrence M.;Lindeman G.;Lipton L.;Lobb L.;Mann G.;Marsh D.;McLachlan S.A.;Meiser B.;Milne R.L.;Nightingale S.;O'Connell S.;O'Sullivan S.;Ortega D.G.;Pachter N.;Patterson B.;Pearn A.;Phillips K.;Pieper E.;Rickard E.;Robinson B.;Saleh M.;Salisbury E.;Saunders C.;Saunus J.;Sexton A.;Shelling A.;Simpson P.;Southey M.C.;Spurdle A.;Taylor J.;Taylor R.;Thorne H.;Trainer A.;Tucker K.;Visvader J.;Walker L.;Williams R.;Winship I.;Young M.A.;Jager A.;Jakubowska A.;John E.M.;Keeman R.;Khusnutdinova E.;Kitahara C.M.;Kosma V.-M.;Koutros S.;Kraft P.;Kristensen V.N.;Kurian A.W.;Lambrechts D.;Le Marchand L.;Linet M.;Lubinski J.;Mannermaa A.;Manoukian S.;Margolin S.;Martens J.W.M.;Mavroudis D.;Mayes R.;Meindl A.;Neuhausen S.L.;Nevanlinna H.;Newman W.G.;Nielsen S.F.;Nordestgaard B.G.;Obi N.;Olshan A.F.;Olson J.E.;Olsson H.;Orban E.;Park-Simon T.-W.;Peterlongo P.;Plaseska-Karanfilska D.;Pylkas K.;Rennert G.;Rennert H.S.;Ruddy K.J.;Saloustros E.;Sandler D.P.;Sawyer E.J.;Schmutzler R.K.;Scott C.;Shu X.-O.;Simard J.;Smichkoska S.;Sohn C.;Spinelli J.J.;Stone J.;Tamimi R.M.;Taylor J.A.;Tollenaar R.A.E.M.;Tomlinson I.;Troester M.A.;Truong T.;Vachon C.M.;van Veen E.M.;Wang S.S.;Weinberg C.R.;Wendt C.;Wildiers H.;Winqvist R.;Wolk A.;Zheng W.;Ziogas A.;Dunning A.M.;Pharoah P.D.P.;Easton D.F.;Howie A.F.;Peto J.;dos-Santos-Silva I.;Swerdlow A.J.;Chang-Claude J.;Schmidt M.K.;Orr N.;Fletcher O.
Institution:	(Johnson, Tomczyk, Fletcher) The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom (Maguire, Orr) Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, United Kingdom (Morra, Keeman, Schmidt) Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands (Kapoor, Campa, Kaaks, Chang-Claude) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (Kapoor) Faculty of Medicine, University of Heidelberg, Heidelberg, Germany (Jones, Schoemaker, Swerdlow) Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom (Gilham, Peto, dos-Santos-Silva) Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom (Bolla, Wang, Dennis, Pharoah, Easton) Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (Ahearn, Freeman, Chanock, Figueroa, Garcia-Closas, Koutros) Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States (Andrulis) Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada (Andrulis) Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada (Anton-Culver, Ziogas) Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, United States (Antonenkova, Bogdanova) N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus (Arndt, Brenner) Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (Aronson) Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, Canada (Augustinsson, Olsson) Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden (Baynes, Conroy, Harrington, Mayes, Dunning, Pharoah, Easton) Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom (Beckmann, Fasching) Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany (Benitez) Centro de Investigacion en Red de Enfermedades Raras (CIBERER), Madrid, Spain (Benitez, Gonzalez-Neira) Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain (Bermisheva, Khusnutdinova) Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation (Blomqvist) Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (Blomqvist) Department of Oncology, Orebro University Hospital, Orebro, Sweden (Boeckx, Lambrechts) VIB Center for Cancer Biology, Leuven, Belgium (Boeckx, Lambrechts) Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium (Bogdanova) Department of Radiation Oncology, Hannover Medical School, Hannover, Germany (Bogdanova, Dork, Park-Simon) Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (Bojesen, Nielsen, Nordestgaard) Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Bojesen, Nielsen, Nordestgaard) Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Bojesen, Nordestgaard) Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (Brauch) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (Brauch) iFIT-Cluster of Excellence, University of Tubingen, Tubingen, Germany (Brauch, Brenner) German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (Brenner) Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany (Burwinkel) Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg, Germany (Burwinkel) Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany (Campa) Department of Biology, University of Pisa, Pisa, Italy (Canzian) Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany (Castelao) Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain (Chenevix-Trench) Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia (Clarke) Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia (Couch) Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States (Cox) Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom (Cross) Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom (Czene, Hall) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (Eliassen) Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States (Eliassen, Hunter, Kraft, Tamimi) Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States (Engel) Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany (Engel) LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany (Evans, Newman, van Veen) Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom (Evans, Newman, van Veen) North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (Fasching) David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, United States (Figueroa) Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, United Kingdom (Figueroa) Cancer Research UK Edinburgh Centre, The University of Edinburgh, Edinburgh, United Kingdom (Floris, Wildiers) Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium (Flyger) Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Gago-Dominguez) Fundacion Publica Galega de Medicina Xenomica, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain (Gago-Dominguez) Moores Cancer Center, University of California San Diego, La Jolla, CA, United States (Gapstur, Gaudet) Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, United States (Giles, Milne, Southey) Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia (Giles, Hopper, Milne, Stone) Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia (Giles, Milne, Southey) Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (Goldberg) Department of Medicine, McGill University, Montreal, QC, Canada (Goldberg) Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada (Guenel, Truong) Center for Research in Epidemiology and Population Health (CESP), Team Exposome and Heredity, INSERM, University Paris-Saclay, Villejuif, France (Hahnen, Schmutzler) Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany (Hahnen, Schmutzler) Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany (Haiman) Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States (Hakansson, Wolk) Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (Hall, Margolin) Department of Oncology, Sodersjukhuset, Stockholm, Sweden (Hamann) Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany (Hart, Olson, Scott) Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States (Hooning, Jager, Martens) Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, Netherlands (Howell) Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom (Hunter) Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (Jakubowska, Lubinski) Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland (Jakubowska) Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland (John, Kurian) Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, United States (John, Kurian) Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, United States (Khusnutdinova) Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation (Kitahara, Linet) Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States (Kosma, Mannermaa) Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland (Kosma, Mannermaa) Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland (Kosma, Mannermaa) Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland (Kraft) Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, United States (Borresen-Dale, Karesen, Sauer, Engebraten, Naume, Geisler, Kristensen) Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway (Kristensen) Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway (Le Marchand) Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, United States (Manoukian) Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy (Margolin, Wendt) Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden (Mavroudis) Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece (Meindl) Department of Gynecology and Obstetrics, University of Munich, Campus Groshadern, Munich, Germany (Neuhausen) Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States (Nevanlinna) Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (Obi) Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Olshan, Troester) Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States (Orban, Chang-Claude) Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Peterlongo) Genome Diagnostics Program, IFOM - the FIRC Institute of Molecular Oncology, Milan, Italy (Plaseska-Karanfilska) Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', MASA, Skopje, North Macedonia (Pylkas, Winqvist) Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland (Pylkas, Winqvist) Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland (Rennert, Rennert) Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel (Ruddy) Department of Oncology, Mayo Clinic, Rochester, MN, United States (Saloustros) Department of Oncology, University Hospital of Larissa, Larissa, Greece (Sandler, Taylor) Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States (Sawyer) School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, United Kingdom (Schmutzler) Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany (Shu, Zheng) Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States (Simard) Genomics Center, Centre Hospitalier Universitaire de Quebec - Universite Laval Research Center, Quebec City, QC, Canada (Smichkoska) Ss. Cyril and Methodius University in Skopje, Medical Faculty, University Clinic of Radiotherapy and Oncology, Skopje, North Macedonia (Sohn) National Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany (Southey) Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia (Spinelli) Population Oncology, BC Cancer, Vancouver, BC, Canada (Spinelli) School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (Stone) The Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, WA, Australia (Tamimi) Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, United States (Taylor) Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States (Tollenaar) Department of Surgery, Leiden University Medical Center, Leiden, Netherlands (Tomlinson) Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom (Tomlinson) Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (Vachon) Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, United States (Wang) Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, United States (Wang) City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, United States (Weinberg) Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States (Wolk) Department of Surgical Sciences, Uppsala University, Uppsala, Sweden (Howie) MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom (Swerdlow) Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom (Schmidt) Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, Netherlands (Borresen-Dale, Alnaes, Sahlberg, Ottestad, Haakensen, Helland) Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway (Sahlberg) Department of Research, Vestre Viken Hospital, Drammen, Norway (Karesen, Schlichting, Riis) Section for Breast- and Endocrine Surgery, Department of Cancer, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital-Ulleval, Oslo, Norway (Holmen) Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway (Sauer) Department of Pathology at Akershus University hospital, Lorenskog, Norway (Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland) Department of Oncology, Division of Surgery and Cancer and Transplantation Medicine, Oslo University Hospital-Radiumhospitalet, Oslo, Norway (Engebraten) Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway (Fossa, Kiserud, Reinertsen) National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Oslo University Hospital, Oslo, Norway (Geisler) Department of Oncology, Akershus University Hospital, Lorenskog, Norway (Geisler) Breast Cancer Research Consortium, Oslo University Hospital, Oslo, Norway (Bowtell) Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia (Bowtell) Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC 3010, Australia (Bowtell) Kinghorn Cancer Centre, Garvan Institute for Medical Research, Darlinghurst, NSW 2010, Australia (deFazio) Centre for Cancer Research, The Westmead Institute for Medical Research, Westmead, NSW 2145, Australia (deFazio) Department of Gynaecological Oncology, Westmead Hospital, Westmead, NSW 2145, Australia (deFazio) The University of Sydney, Sydney, NSW 2052, Australia (Chenevix-Trench, Webb) QIMR Berghofer Medical Research Institute, Locked Bag 2000 Royal Brisbane Hospital, Brisbane, QLD 4029, Australia (Clarke, Graham, Sachchithananthan) Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia (Marsh) University of Technology Sydney, Translational Oncology Group, School of Life Sciences, Faculty of Science, Ultimo, NSW, Australia (Scott) School of Biomedical Sciences, University of Newcastle, Newcastle, Australia (Scott) Hunter Medical Research Institute and NSW Health Pathology North, Newcastle, Australia (Baxter) Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW, Australia (Yip) Epigenetics & Transcription Laboratory Melanie Swan Memorial Translational Centre, Sci-Tech, University of Canberra, Canberra, ACT, Australia (Yip) Department of Medical Oncology, The Canberra Hospital, Garran, ACT, Australia (Carpenter) Scientific Platforms, The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia (Davis) The Canberra Hospital, Garran, ACT, Australia (Davis) The Australian National University, Canberra, ACT, Australia (Pathmanathan) Westmead Breast Cancer Institute, Western Sydney Local Health District, Westmead, NSW, Australia (Pathmanathan) University of Sydney, Western Clinical School, Westmead, NSW, Australia (Simpson) UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Herston, QLD, Australia (Amor) Genetic Health Services, Victoria Royal Children's Hospital, Melbourne, VIC 3050, Australia (Andrews, Koehler, Meiser) Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Antill) Dept. Haem and Medical Oncology, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC 3002, Australia (Balleine) Department of Translational Oncology, c/o Department of Medical Oncology, Westmead Hospital, Westmead, NSW 2145, Australia (Beesley) Queensland Institute of Medical Research, Herston Road, Herston, QLD 4002, Australia (Bennett) Silverton Place, 101 Wickham Terrace, Brisbane, QLD 4000, Australia (Bogwitz) Familial Cancer Centre, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia (Botes) Hereditary Cancer Centre, Prince of Wales Hospital, Barker St, Randwick, NSW 2031, Australia (Brennan) NSW Breast Cancer Institute, PO Box 143, Westmead, NSW 2145, Australia (Brown) Department of Biochemistry, University of Queensland, St. Lucia, QLD 4072, Australia (Buckley) Molecular and Cytogenetics Unit, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Burke) Royal Hobart Hospital, GPO Box 1061L, Hobart, TAS 7001, Australia (Butow) Medical Psychology Unit, Royal Prince Alfred Hospital, Camperdown, NSW 2204, Australia (Caldon) Replication and Genome Stability, Cancer Division, Garvan Institute of Medical Research, 370 Victoria Street, Darlinghurst, NSW 2010, Australia (Campbell) Peter MacCallum Cancer Centre St Andrew's Place, East Melbourne, VIC 3002, Australia (Chauhan) School of Psychology, Brennan McCallum (Building A18), University of Sydney, Sydney, NSW 2006, Australia (Chauhan) St Vincents Hospital, Cancer Genetics Clinic, The Kinghorn Cancer Centre, Sydney, NSW 2010, Australia (Chenevix-Trench) Queensland Institute of Medical Research, Royal Brisbane Hospital, Herston, QLD 4029, Australia (Christian) Genetics Department, Central Region Genetics Service, Wellington Hospital, Wellington, New Zealand (Cohen) Gynaecological Cancer Research, St John of God Subiaco Hospital, 12 Salvado Road, Subiaco, WA 6008, Australia (Colley) Department of Clinical Genetics, Liverpool Health Service, PO Box 103, Liverpool, NSW 2170, Australia (Crook) Department of Clinical Genetics, Level 3E, Royal North Shore Hospital, St Leonards, NSW 2065, Australia (Cui) Epidemiology and Preventive Medicine, Monash University, Prahan, Vic 3004, Australia (Cummings) Department of Pathology, University of Queensland Medical School, Herston, NSW 4006, Australia (Dawson) Molecular Genetics Department, Cambridge University, Cambridge, United Kingdom (DeFazio) Dept. Gynaecological Oncology, Westmead Institute for Cancer Research, Westmead Hospital, Westmead, NSW 2145, Australia (Delatycki) Clinical Genetics, Austin Health, Heidelberg Repatriation Hospital, PO Box 5444, Heidelberg West, Vic 3081, Australia (Dickson) Level 2, Block 51, Royal North Shore Hospital, North Shore, NSW 2408, Australia (Dixon) Central Regional Genetic Services, Wellington Hospital, Private Bag, Wellington 7902, New Zealand (Edkins) Clinical Chemistry, Princess Margret Hospital for Children, Box D184, Perth, WA 6001, Australia (Edwards) Department of Biochemistry and Molecular Biology, University of Queensland, St Lucia, Qld 4072, Australia (Farshid) Tissue Pathology, IMVS, Adelaide, SA 5000, Australia (Fellows) Molecular Diagnostic Development, Pathology Department, Peter MacCallum Cancer Centre, Melbourne East, Melbourne, VIC 3002, Australia (Fenton) South West Family Cancer Clinic, Liverpool Hospital, Liverpool BC, NSW 1871, Australia (Field) Royal North Shore Hospital, Level 2, Vindin House, St Leonards, NSW 2065, Australia (Flanagan) Epigenetics Unit, Department of Surgery and Oncology, Imperial College London, London W12 0NN, United Kingdom (Fong) Medical Oncology Department, Regional Cancer and Blood Services, Level 1 Building 7, Auckland City Hospital, 2 Park Rd., Grafton, Auckland 1023, New Zealand (Forrest) Psychosocial Cancer Genetics Research Group, Parkville Familial Cancer Centre, 305 Grattan Street, Melbourne, Vic 3000, Australia (Fox) Pathology Department, Level 1, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, Vic 3002, Australia (French) School of Molecular and Microbial Sciences, University of Queensland, St Lucia, Qld 4072, Australia (Friedlander) Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Gaff) Victorian Clinical Genetics Service, Royal Melbourne Hospital, Parkville, VIC 3052, Australia (Gattas) Queensland Clinical Genetic Service, Royal Children's Hospital, Bramston Terrace, Herston, QLD 4020, Australia (George) Clinical Biochemistry Unit, Canterbury Health Labs, PO Box 151, Christchurch, New Zealand (Greening) Illawarra Cancer Centre, Wollongong Hospital, Private Mail Bag 8808, South Coast Mail Centre, Wollongong, NSW 2521, Australia (Harris) Familial Cancer Clinic, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, VIC 3002, Australia (Hart) Breast and Ovarian Cancer Genetics, Monash Medical Centre, 871 Centre Road, Bentleigh East, VIC 3165, Australia (Hayward) Queensland Institute for Medical Research, Royal Brisbane Hospital, Post Office, Herston, QLD 4029, Australia (Hopper) Centre for M.E.G.A. Epidemiology, University of Melbourne, Level 1, 723 Swanston Street, Carlton, VIC 3010, Australia (Hoskins) Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre & The Royal Melbourne Hospital, Melbourne, VIC 3000, Australia (Hunt) Southern Health Familial Cancer Centre, Monash Medical Centre, Special Medicine Building, 246 Clayton Rd, Clayton, VIC 3168, Australia (James) Genetic Health Sevices, Monash Medical Centre, Clayton, Vic 3168, Australia (Jenkins) Centre for M.E.G.A. Epidemiology, The University of Melbourne, 723 Swanston Street, Carlton, VIC 3053, Australia (Kidd) Clinical Genetics Departments, Central Regional Genetics Service, Wellington Hospital, Wellington, New Zealand (Kirk) Familial Cancer Service, Department of Medicine, Westmead Hospital, Westmead, NSW 2145, Australia (Kollias) Breast Endocrine and Surgical Unit, Royal Adelaide Hospital, North Terrace, SA 5000, Australia (Lakhani) UQ Centre for Clinical Research, Level 6, Building 71/918, University of Queensland, The Royal Brisbane & Women's Hospital, Herston, QLD 4029, Australia (Lawrence) Prostate Cancer Research Program, 19 Innovation Walk, Level 3, Monash University, Clayton, VIC 3800, Australia (Lindeman) Breast Cancer Laboratory, Walter and Eliza Hall Institute, PO Royal Melbourne Hospital, Parkville, VIC 3050, Australia (Lipton) Medical Oncology and Clinical Haematology Unit, Western Hospital, Footscray, VIC 3011, Australia (Lobb) Medical Psychology Research Unit, Room 332, Brennan MacCallum Building (A18), The University of Sydney, Camperdown, NSW 2006, Australia (Mann) Westmead Institute for Cancer Research, Westmead Millennium Institute, Westmead, NSW 2145, Australia (Marsh) Kolling Institute of Medical Research, Royal North Shore Hospital, St Leonards, NSW 2065, Australia (McLachlan) Department of Oncology, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC 3065, Australia (Milne) Centro Nacional de Investigaciones Oncologicas, C/ Melchor Fernandez Almagro, Madrid 3E-28029, Spain (Nightingale) Western Health and Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, VIC 3002, Australia (O'Connell) Southern Health Familial Cancer Centre, Special Medicine Building, 246 Clayton Road, Clayton, Vic 3168, Australia (O'Sullivan) Genetic Services of Western, Level 3 Agnes Walsh House, 374 Bagot Road, Subiaco, WA 6008, Australia (Ortega) Tumour Development Group, Garvan Institute of Medical Research, The Kinghorn Cancer Centre, 370 Victoria St, Darlinghurst, NSW 2010, Australia (Pachter) Familial Cancer and Clinical Genetics, Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia (Patterson) Tas Clinical Genetics Service, Royal Hobart Hospital, GPO Box 1061, Hobart, TAS 7001, Australia (Pearn) The Gene Council, Perth, Australia, PO Box 510, North Perth, WA 6906, Australia (Phillips) Department of Medical Oncology, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, VIC 3002, Australia (Pieper) Parkville Familial Cancer Centre and Genomic Medicine, VCCC Grattan Street, Melbourne, Vic 3000, Australia (Rickard) Familial Cancer centre, Westmead Hospital, Westmead, NSW 2145, Australia (Robinson) Oncology Service, Christchurch Hospital, Private Bag, Christchurch 4710, New Zealand (Saleh) Centre for Genetic Education, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Salisbury) Anatomical Pathology, UNSW, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Saunders) School of Surgery and Pathology, QE11 Medical Centre, M block, 2nd Floor, Nedlands, WA 6907, Australia (Saunus) Breast Pathology, University of Queensland, Centre for Clinical Research, Building 71/918, Royal Brisbane and Women's Hospital, Herston, QLD 4029, Australia (Scott) Hunter Area Pathology Service, John Hunter Hospital, Locked Bag 1 Regional Mail Centre, New Lambton Heights, NSW 2310, Australia (Scott) Research Department, WEHI c/o Royal Melbourne Hospital, Parkville, VIC 3050, Australia (Sexton) Familial Cancer Centre, Royal Melbourne Hospital, Grattan Street, Parkville, Vic 3050, Australia (Shelling) Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand (Simpson) The University of Queensland, Building 71/918, RBWH Campus, Herston, Qld 4029, Australia (Southey) Genetic Epidemiology Laboratory, Departemnt of Pathology, University of Melbourne, Melbourne, VIC 3010, Australia (Spurdle) Cancer Unit, Queensland Institute of Medical Research, Herston, QLD 4029, Australia (Taylor) Familial Cancer and Genetics Medicine, Royal Melbourne Hospital, 2nd Floor, Grattan Street, Parkville, Vic 3050, Australia (Taylor) Cancer Program, Monash University, Rm 349, Level 3, Building 7619, Innovation Walk, Clayton, VIC 3800, Australia (Thorne) Research Department, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, VIC 3002, Australia (Trainer) University of NSW, Prince of Wales Hospital, Barker Street, Randwick, NSW 2031, Australia (Tucker) Heredity Cancer Clinic, Prince of Wales Hospital, Randwick, NSW 2031, Australia (Visvader) The Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, Parkville, VIC 3050, Australia (Walker) Molecular Cancer Epidemiology Laboratory, Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Herston, Qld 4027, Australia (Williams) Family Cancer Clinic, St Vincent's Hospital, Darlinghurst, NSW 2010, Australia (Winship) Department of Genetics, Royal Melbourne Hospital, Parkville, VIC 3050, Australia (Young) Genome.One, 370 Victoria St, Darlinghurst, NSW 2010, Australia
Issue Date:	14-May-2021
Copyright year:	2021
Publisher:	Springer Nature
Place of publication:	United Kingdom
Publication information:	British Journal of Cancer. 124 (4) (pp 842-854), 2021. Date of Publication: 16 Feb 2021.
Journal:	British Journal of Cancer
Abstract:	Background: Epidemiological studies provide strong evidence for a role of endogenous sex hormones in the aetiology of breast cancer. The aim of this analysis was to identify genetic variants that are associated with urinary sex-hormone levels and breast cancer risk. Method(s): We carried out a genome-wide association study of urinary oestrone-3-glucuronide and pregnanediol-3-glucuronide levels in 560 premenopausal women, with additional analysis of progesterone levels in 298 premenopausal women. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. All women were of European ancestry. Result(s): For pregnanediol-3-glucuronide, there were no genome-wide significant associations; for oestrone-3-glucuronide, we identified a single peak mapping to the CYP3A locus, annotated by rs45446698. The minor rs45446698-C allele was associated with lower oestrone-3-glucuronide (-49.2%, 95% CI -56.1% to -41.1%, P = 3.1 x 10-18); in follow-up analyses, rs45446698-C was also associated with lower progesterone (-26.7%, 95% CI -39.4% to -11.6%, P = 0.001) and reduced risk of oestrogen and progesterone receptor-positive breast cancer (OR = 0.86, 95% CI 0.82-0.91, P = 6.9 x 10-8). Conclusion(s): The CYP3A7*1C allele is associated with reduced risk of hormone receptor-positive breast cancer possibly mediated via an effect on the metabolism of endogenous sex hormones in premenopausal women.Copyright © 2021, The Author(s).
DOI:	http://monash.idm.oclc.org/login?url=http://dx.doi.org/10.1038/s41416-020-01185-w
PubMed URL:	33495599 [http://www.ncbi.nlm.nih.gov/pubmed/?term=33495599]
URI:	https://repository.monashhealth.org/monashhealthjspui/handle/1/43128
Type:	Article
Subjects:	breast cancer/et [Etiology] estrogen receptor positive breast cancer/et [Etiology] gene frequency genetic risk genetic variability genome-wide association study genotype premenopause progesterone receptor positive breast cancer/et [Etiology] risk reduction single nucleotide polymorphism urine level cytochrome P450 3A7/ec [Endogenous Compound] estrone/ec [Endogenous Compound] estrone derivative/ec [Endogenous Compound] estrone glucuronide/ec [Endogenous Compound] progesterone/ec [Endogenous Compound] unclassified drug pregnanediol 3 glucuronide/ec [Endogenous Compound]
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