Mendelian randomisation study of smoking exposure in relation to breast cancer risk.

Park H.A.; Neumeyer S.; Michailidou K.; Bolla M.K.; Wang Q.; Dennis J.; Ahearn T.U.; Andrulis I.L.; Anton-Culver H.; Antonenkova N.N.; Arndt V.; Aronson K.J.; Augustinsson A.; Baten A.; Beane Freeman L.E.; Becher H.; Beckmann M.W.; Behrens S.; Benitez J.; Bermisheva M.; Bogdanova N.V.; Bojesen S.E.; Brauch H.; Brenner H.; Brucker S.Y.; Burwinkel B.; Campa D.; Canzian F.; Castelao J.E.; Chanock S.J.; Clarke C.L.; Borresen-Dale A.-L.; Grenaker Alnaes G.I.; Sahlberg K.K.; Ottestad L.; Karesen R.; Schlichting E.; Holmen M.M.; Sauer T.; Haakensen V.; Engebraten O.; Naume B.; Fossa A.; Kiserud C.E.; Reinertsen K.V.; Helland A.; Riis M.; Geisler J.; Conroy D.M.; Couch F.J.; Cox A.; Cross S.S.; Czene K.; Daly M.B.; Devilee P.; Dork T.; dos-Santos-Silva I.; Dwek M.; Eccles D.M.; Eliassen A.H.; Engel C.; Eriksson M.; Evans D.G.; Fasching P.A.; Flyger H.; Fritschi L.; Garcia-Closas M.; Garcia-Saenz J.A.; Gaudet M.M.; Giles G.G.; Glendon G.; Goldberg M.S.; Goldgar D.E.; Gonzalez-Neira A.; Grip M.; Guenel P.; Hahnen E.; Haiman C.A.; Hakansson N.; Hall P.; Hamann U.; Han S.; Harkness E.F.; Hart S.N.; He W.; Heemskerk-Gerritsen B.A.M.; Hopper J.L.; Hunter D.J.; Clarke C.; Baxter R.; Yip D.; Carpenter J.; Davis A.; Pathmanathan N.; Graham D.; Sachchithananthan M.; Amor D.; Andrews L.; Antill Y.; Balleine R.; Beesley J.; Bennett I.; Bogwitz M.; Botes L.; Brennan M.; Brown M.; Buckley M.; Burke J.; Butow P.; Caldon L.; Campbell I.; Chauhan D.; Chauhan M.; Chenevix-Trench G.; Christian A.; Cohen P.; Colley A.; Crook A.; Cui J.; Cummings M.; Dawson S.-J.; DeFazio A.; Delatycki M.; Dickson R.; Dixon J.; Edkins T.; Edwards S.; Farshid G.; Fellows A.; Fenton G.; Field M.; Flanagan J.; Fong P.; Forrest L.; Fox S.; French J.; Friedlander M.; Gaff C.; Gattas M.; George P.; Greening S.; Harris M.; Hart S.; Hayward N.; Hopper J.; Hoskins C.; Hunt C.; James P.; Jenkins M.; Kidd A.; Kirk J.; Koehler J.; Kollias J.; Lakhani S.; Lawrence M.; Lindeman G.; Lipton L.; Lobb L.; Mann G.; Marsh D.; McLachlan S.A.; Meiser B.; Milne R.; Nightingale S.; O'Connell S.; O'Sullivan S.; Ortega D.G.; Pachter N.; Patterson B.; Pearn A.; Phillips K.; Pieper E.; Rickard E.; Robinson B.; Saleh M.; Salisbury E.; Saunders C.; Saunus J.; Scott R.; Sexton A.; Shelling A.; Simpson P.; Southey M.; Spurdle A.; Taylor J.; Taylor R.; Thorne H.; Trainer A.; Tucker K.; Visvader J.; Walker L.; Williams R.; Winship I.; Young M.A.; Jager A.; Jakubowska A.; John E.M.; Jung A.; Kaaks R.; Kapoor P.M.; Keeman R.; Khusnutdinova E.; Kitahara C.M.; Koppert L.B.; Koutros S.; Kristensen V.N.; Kurian A.W.; Lacey J.; Lambrechts D.; Le Marchand L.; Lo W.-Y.; Lubinski J.; Mannermaa A.; Manoochehri M.; Margolin S.; Martinez M.E.; Mavroudis D.; Meindl A.; Menon U.; Milne R.L.; Muranen T.A.; Nevanlinna H.; Newman W.G.; Nordestgaard B.G.; Offit K.; Olshan A.F.; Olsson H.; Park-Simon T.-W.; Peterlongo P.; Peto J.; Plaseska-Karanfilska D.; Presneau N.; Radice P.; Rennert G.; Rennert H.S.; Romero A.; Saloustros E.; Sawyer E.J.; Schmidt M.K.; Schmutzler R.K.; Schoemaker M.J.; Schwentner L.; Scott C.; Shah M.; Shu X.-O.; Simard J.; Smeets A.; Southey M.C.; Spinelli J.J.; Stevens V.; Swerdlow A.J.; Tamimi R.M.; Tapper W.J.; Taylor J.A.; Terry M.B.; Tomlinson I.; Troester M.A.; Truong T.; Vachon C.M.; van Veen E.M.; Vijai J.; Wang S.; Wendt C.; Winqvist R.; Wolk A.; Ziogas A.; Dunning A.M.; Pharoah P.D.P.; Easton D.F.; Zheng W.; Kraft P.; Chang-Claude J.

Please use this identifier to cite or link to this item: https://repository.monashhealth.org/monashhealthjspui/handle/1/47064

Title:	Mendelian randomisation study of smoking exposure in relation to breast cancer risk.
Authors:	Park H.A.;Neumeyer S.;Michailidou K.;Bolla M.K.;Wang Q.;Dennis J.;Ahearn T.U.;Andrulis I.L.;Anton-Culver H.;Antonenkova N.N.;Arndt V.;Aronson K.J.;Augustinsson A.;Baten A.;Beane Freeman L.E.;Becher H.;Beckmann M.W.;Behrens S.;Benitez J.;Bermisheva M.;Bogdanova N.V.;Bojesen S.E.;Brauch H.;Brenner H.;Brucker S.Y.;Burwinkel B.;Campa D.;Canzian F.;Castelao J.E.;Chanock S.J.;Clarke C.L.;Borresen-Dale A.-L.;Grenaker Alnaes G.I.;Sahlberg K.K.;Ottestad L.;Karesen R.;Schlichting E.;Holmen M.M.;Sauer T.;Haakensen V.;Engebraten O.;Naume B.;Fossa A.;Kiserud C.E.;Reinertsen K.V.;Helland A.;Riis M.;Geisler J.;Conroy D.M.;Couch F.J.;Cox A.;Cross S.S.;Czene K.;Daly M.B.;Devilee P.;Dork T.;dos-Santos-Silva I.;Dwek M.;Eccles D.M.;Eliassen A.H.;Engel C.;Eriksson M.;Evans D.G.;Fasching P.A.;Flyger H.;Fritschi L.;Garcia-Closas M.;Garcia-Saenz J.A.;Gaudet M.M.;Giles G.G.;Glendon G.;Goldberg M.S.;Goldgar D.E.;Gonzalez-Neira A.;Grip M.;Guenel P.;Hahnen E.;Haiman C.A.;Hakansson N.;Hall P.;Hamann U.;Han S.;Harkness E.F.;Hart S.N.;He W.;Heemskerk-Gerritsen B.A.M.;Hopper J.L.;Hunter D.J.;Clarke C.;Baxter R.;Yip D.;Carpenter J.;Davis A. ;Pathmanathan N.;Graham D.;Sachchithananthan M.;Amor D.;Andrews L.;Antill Y.;Balleine R.;Beesley J.;Bennett I.;Bogwitz M.;Botes L.;Brennan M.;Brown M.;Buckley M.;Burke J.;Butow P.;Caldon L.;Campbell I.;Chauhan D.;Chauhan M.;Chenevix-Trench G.;Christian A.;Cohen P.;Colley A.;Crook A.;Cui J.;Cummings M.;Dawson S.-J.;DeFazio A.;Delatycki M.;Dickson R.;Dixon J.;Edkins T.;Edwards S.;Farshid G.;Fellows A.;Fenton G.;Field M.;Flanagan J.;Fong P.;Forrest L.;Fox S.;French J.;Friedlander M.;Gaff C.;Gattas M.;George P.;Greening S.;Harris M. ;Hart S.;Hayward N.;Hopper J.;Hoskins C.;Hunt C.;James P.;Jenkins M.;Kidd A.;Kirk J.;Koehler J.;Kollias J.;Lakhani S.;Lawrence M.;Lindeman G.;Lipton L.;Lobb L.;Mann G.;Marsh D.;McLachlan S.A.;Meiser B.;Milne R.;Nightingale S.;O'Connell S.;O'Sullivan S.;Ortega D.G.;Pachter N.;Patterson B.;Pearn A.;Phillips K.;Pieper E.;Rickard E.;Robinson B.;Saleh M.;Salisbury E.;Saunders C.;Saunus J.;Scott R.;Sexton A.;Shelling A.;Simpson P.;Southey M.;Spurdle A.;Taylor J.;Taylor R.;Thorne H.;Trainer A.;Tucker K.;Visvader J.;Walker L.;Williams R.;Winship I.;Young M.A.;Jager A.;Jakubowska A.;John E.M.;Jung A.;Kaaks R.;Kapoor P.M.;Keeman R.;Khusnutdinova E.;Kitahara C.M.;Koppert L.B.;Koutros S.;Kristensen V.N.;Kurian A.W.;Lacey J.;Lambrechts D.;Le Marchand L.;Lo W.-Y.;Lubinski J.;Mannermaa A.;Manoochehri M.;Margolin S.;Martinez M.E.;Mavroudis D.;Meindl A.;Menon U.;Milne R.L.;Muranen T.A.;Nevanlinna H.;Newman W.G.;Nordestgaard B.G.;Offit K.;Olshan A.F.;Olsson H.;Park-Simon T.-W.;Peterlongo P.;Peto J.;Plaseska-Karanfilska D.;Presneau N.;Radice P.;Rennert G.;Rennert H.S.;Romero A.;Saloustros E.;Sawyer E.J.;Schmidt M.K.;Schmutzler R.K.;Schoemaker M.J.;Schwentner L.;Scott C.;Shah M.;Shu X.-O.;Simard J.;Smeets A.;Southey M.C.;Spinelli J.J.;Stevens V.;Swerdlow A.J.;Tamimi R.M.;Tapper W.J.;Taylor J.A.;Terry M.B.;Tomlinson I.;Troester M.A.;Truong T.;Vachon C.M.;van Veen E.M.;Vijai J.;Wang S.;Wendt C.;Winqvist R.;Wolk A.;Ziogas A.;Dunning A.M.;Pharoah P.D.P.;Easton D.F.;Zheng W.;Kraft P.;Chang-Claude J.
Monash Health Department(s):	Monash University - School of Clinical Sciences at Monash Health
Institution:	(Park, Neumeyer, Behrens, Campa, Jung, Kaaks, Kapoor, Chang-Claude) Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (Park, Kapoor) Faculty of Medicine, University of Heidelberg, Heidelberg, Germany (Michailidou) Biostatistics Unit, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus (Michailidou) Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology & Genetics, Nicosia, Cyprus (Michailidou, Bolla, Wang, Dennis, Pharoah, Easton) Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom (Ahearn, Beane Freeman, Chanock, Garcia-Closas, Koutros) Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, United States (Andrulis, Glendon) Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada (Andrulis) Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada (Anton-Culver, Ziogas) Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, CA, United States (Antonenkova, Bogdanova) N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus (Arndt, Brenner) Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany (Aronson) Department of Public Health Sciences, and Cancer Research Institute, Queen's University, Kingston, ON, Canada (Augustinsson, Olsson) Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden (Baten, Han) Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium (Becher) Institute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Becher) Institute of Biometry and Clinical Epidemiology, Charite -Universitatsmedizin Berlin, Berlin, Germany (Beckmann, Fasching) Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany (Benitez) Centro de Investigacion en Red de Enfermedades Raras (CIBERER), Madrid, Spain (Benitez, Gonzalez-Neira) Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain (Bermisheva, Khusnutdinova) Institute of Biochemistry and Genetics, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation (Bogdanova) Department of Radiation Oncology, Hannover Medical School, Hannover, Germany (Bogdanova, Dork, Park-Simon) Gynaecology Research Unit, Hannover Medical School, Hannover, Germany (Bojesen, Nordestgaard) Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Bojesen, Nordestgaard) Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Bojesen, Nordestgaard) Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark (Brauch, Lo) Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany (Brauch) iFIT-Cluster of Excellence, University of Tubingen, Tubingen, Germany (Brauch) German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Partner Site Tubingen, Tubingen, Germany (Brenner) Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany (Brenner) German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany (Brucker) Department of Gynecology and Obstetrics, University of Tubingen, Tubingen, Germany (Burwinkel) Molecular Epidemiology Group, C080, German Cancer Research Center (DKFZ), Heidelberg, Germany (Burwinkel) Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, University of Heidelberg, Heidelberg, Germany (Campa) Department of Biology, University of Pisa, Pisa, Italy (Canzian) Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany (Castelao) Oncology and Genetics Unit, Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Vigo, Spain (Chenevix-Trench) Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia (Clarke) Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia (Conroy, Shah, Dunning, Pharoah, Easton) Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom (Couch) Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States (Cox, Cross) Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom (Cross) Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom (Czene, Eriksson, Hall, He) Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (Daly) Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, United States (Devilee) Department of Pathology, Leiden University Medical Center, Leiden, Netherlands (Devilee) Department of Human Genetics, Leiden University Medical Center, Leiden, Netherlands (dos-Santos-Silva, Peto) Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom (Dwek, Presneau) School of Life Sciences, University of Westminster, London, United Kingdom (Eccles, Tapper) Faculty of Medicine, University of Southampton, Southampton, United Kingdom (Eliassen, Tamimi) Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States (Eliassen, Hunter, Tamimi, Kraft) Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States (Engel) Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany (Evans, Newman, van Veen) Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom (Evans, Newman, van Veen) North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (Fasching) David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, CA, United States (Flyger) Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark (Fritschi) School of Public Health, Curtin University, Perth, WA, Australia (Garcia-Saenz) Medical Oncology Department, Hospital Clinico San Carlos, Instituto de Investigacion Sanitaria San Carlos (IdISSC), Centro Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain (Gaudet, Stevens) Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, United States (Giles, Milne, Southey) Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia (Giles, Hopper, Milne) Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia (Giles, Milne, Southey) Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (Goldberg) Department of Medicine, McGill University, Montreal, QC, Canada (Goldberg) Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, QC, Canada (Goldgar) Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT, United States (Grip) Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland (Guenel, Truong) Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France (Hahnen, Schmutzler) Center for Familial Breast and Ovarian Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany (Hahnen, Schmutzler) Center for Integrated Oncology (CIO), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany (Haiman) Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States (Hakansson, Wolk) Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (Hall, Margolin) Department of Oncology, Sodersjukhuset, Stockholm, Sweden (Hamann, Manoochehri) Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany (Harkness) Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom (Harkness) Nightingale & Genesis Prevention Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom (Harkness) NIHR Manchester Biomedical Research Unit, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom (Hart, Scott) Department of Health Sciences Research, Mayo Clinic, Rochester, MN, United States (Heemskerk-Gerritsen, Jager) Department of Medical Oncology, Erasmus MC Cancer Institute, Rotterdam, Netherlands (Hunter, Tamimi, Kraft) Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, United States (Hunter) Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (Jakubowska, Lubinski) Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland (Jakubowska) Independent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, Szczecin, Poland (John, Kurian) Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA, United States (John, Kurian) Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, United States (Keeman, Schmidt) Division of Molecular Pathology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands (Khusnutdinova) Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation (Kitahara) Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States (Koppert) Department of Surgical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, Netherlands (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler, Kristensen) Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway (Lacey, Wang) Department of Computational and Quantitative Medicine, City of Hope, Duarte, CA, United States (Lacey, Wang) City of Hope Comprehensive Cancer Center, City of Hope, Duarte, CA, United States (Lambrechts) VIB Center for Cancer Biology, Leuven, Belgium (Lambrechts) Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium (Le Marchand) Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, United States (Lo) University of Tubingen, Tubingen, Germany (Mannermaa) Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland (Mannermaa) Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland (Mannermaa) Biobank of Eastern Finland, Kuopio University Hospital, Kuopio, Finland (Margolin, Wendt) Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden (Martinez) Moores Cancer Center, University of California San Diego, La Jolla, CA, United States (Martinez) Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, United States (Mavroudis) Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece (Meindl) Department of Gynecology and Obstetrics, University of Munich, Campus Groshadern, Munich, Germany (Menon) MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, United Kingdom (Muranen, Nevanlinna) Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland (Offit, Vijai) Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, United States (Offit, Vijai) Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States (Olshan, Troester) Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States (Peterlongo) Genome Diagnostics Program, IFOM - the FIRC Institute of Molecular Oncology, Milan, Italy (Plaseska-Karanfilska) Research Centre for Genetic Engineering and Biotechnology 'Georgi D, Efremov', MASA, Skopje, North Macedonia (Radice) Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy (Rennert, Rennert) Clalit National Cancer Control Center, Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel (Romero) Medical Oncology Department, Hospital Universitario Puerta de Hierro, Madrid, Spain (Saloustros) Department of Oncology, University Hospital of Larissa, Larissa, Greece (Sawyer) School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London, United Kingdom (Schmidt) Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, Netherlands (Schmutzler) Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany (Schoemaker, Swerdlow) Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom (Schwentner) Department of Gynaecology and Obstetrics, University Hospital Ulm, Ulm, Germany (Shu, Zheng) Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, United States (Simard) Genomics Center, Centre Hospitalier Universitaire de Quebec - Universite Laval Research Center, Quebec City, QC, Canada (Smeets) Department of Surgical Oncology, University Hospitals Leuven, Leuven, Belgium (Southey) Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia (Spinelli) Population Oncology, BC Cancer, Vancouver, BC, Canada (Spinelli) School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada (Swerdlow) Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom (Taylor) Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States (Taylor) Epigenetic and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States (Terry) Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States (Tomlinson) Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom (Tomlinson) Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom (Vachon) Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, MN, United States (Winqvist) Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland (Winqvist) Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre Oulu, Oulu, Finland (Wolk) Department of Surgical Sciences, Uppsala University, Uppsala, Sweden (Chang-Claude) Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital-Radiumhospitalet, Oslo, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Department of Research, Vestre Viken Hospital, Drammen, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Section for Breast- and Endocrine Surgery, Department of Cancer, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital-Ulleval, Oslo, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Department of Pathology, Akershus University Hospital, Lorenskog, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Department of Oncology, Division of Surgery, Cancer and Transplantation Medicine, Oslo University Hospital-Radiumhospitalet, Oslo, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) National Advisory Unit on Late Effects after Cancer Treatment, Oslo University Hospital-Radiumhospitalet, Oslo, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Department of Oncology, Akershus University Hospital, Lorenskog, Norway (Borresen-Dale, Grenaker Alnaes, Sahlberg, Ottestad, Karesen, Schlichting, Holmen, Sauer, Haakensen, Engebraten, Naume, Fossa, Kiserud, Reinertsen, Helland, Riis, Geisler) Breast Cancer Research Consortium, Oslo University Hospital, Oslo, Norway (Clarke, Marsh, Scott, Baxter, Yip, Carpenter, Davis, Pathmanathan, Simpson, Graham, Sachchithananthan) Australian Breast Cancer Tissue Bank, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, Australia (Amor, Andrews, Antill, Balleine, Beesley, Bennett, Bogwitz, Botes, Brennan, Brown, Buckley, Burke, Butow, Caldon, Campbell, Chauhan, Chauhan, Chenevix-Trench, Christian, Cohen, Colley, Crook, Cui, Cummings, Dawson, DeFazio, Delatycki, Dickson, Dixon, Edkins, Edwards, Farshid, Fellows, Fenton, Field, Flanagan, Fong, Forrest, Fox, French, Friedlander, Gaff, Gattas, George, Greening, Harris, Hart, Hayward, Hopper, Hoskins, Hunt, James, Jenkins, Kidd, Kirk, Koehler, Kollias, Lakhani, Lawrence, Lindeman, Lipton, Lobb, Mann, Marsh, McLachlan, Meiser, Milne, Nightingale, O'Connell, O'Sullivan, Ortega, Pachter, Patterson, Pearn, Phillips, Pieper, Rickard, Robinson, Saleh, Salisbury, Saunders, Saunus, Scott, Scott, Sexton, Shelling, Simpson, Southey, Spurdle, Taylor, Taylor, Thorne, Trainer, Tucker, Visvader, Walker, Williams, Winship, Young) Research department, Peter MacCallum Cancer Center, Melbourne, VIC, Australia (Amor, Andrews, Antill, Balleine, Beesley, Bennett, Bogwitz, Botes, Brennan, Brown, Buckley, Burke, Butow, Caldon, Campbell, Chauhan, Chauhan, Chenevix-Trench, Christian, Cohen, Colley, Crook, Cui, Cummings, Dawson, DeFazio, Delatycki, Dickson, Dixon, Edkins, Edwards, Farshid, Fellows, Fenton, Field, Flanagan, Fong, Forrest, Fox, French, Friedlander, Gaff, Gattas, George, Greening, Harris, Hart, Hayward, Hopper, Hoskins, Hunt, James, Jenkins, Kidd, Kirk, Koehler, Kollias, Lakhani, Lawrence, Lindeman, Lipton, Lobb, Mann, Marsh, McLachlan, Meiser, Milne, Nightingale, O'Connell, O'Sullivan, Ortega, Pachter, Patterson, Pearn, Phillips, Pieper, Rickard, Robinson, Saleh, Salisbury, Saunders, Saunus, Scott, Scott, Sexton, Shelling, Simpson, Southey, Spurdle, Taylor, Taylor, Thorne, Trainer, Tucker, Visvader, Walker, Williams, Winship, Young) Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia
Issue Date:	26-Jan-2022
Copyright year:	2021
Publisher:	Springer Nature
Place of publication:	United Kingdom
Publication information:	British Journal of Cancer. 125(8) (pp 1135-1145), 2021. Date of Publication: 12 Oct 2021.
Journal:	British Journal of Cancer
Abstract:	Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Method(s): We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics for 164 single-nucleotide polymorphisms (SNPs) reported in genome-wide association studies of lifetime smoking index (LSI) or cigarette per day (CPD) were used to obtain MR effect estimates. Data from 108,420 invasive breast cancer cases and 87,681 controls were used for the LSI analysis and for the CPD analysis conducted among ever-smokers from 26,147 cancer cases and 26,072 controls. Sensitivity analyses were conducted to address pleiotropy. Result(s): Genetically predicted LSI was associated with increased breast cancer risk (OR 1.18 per SD, 95% CI: 1.07-1.30, P = 0.11 x 10-2), but there was no evidence of association for genetically predicted CPD (OR 1.02, 95% CI: 0.78-1.19, P = 0.85). The sensitivity analyses yielded similar results and showed no strong evidence of pleiotropic effect. Conclusion(s): Our MR study provides supportive evidence for a potential causal association with breast cancer risk for lifetime smoking exposure but not cigarettes per day among smokers.Copyright © 2021, The Author(s).
DOI:	http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1038/s41416-021-01432-8
PubMed URL:	34341517 [https://www.ncbi.nlm.nih.gov/pubmed/?term=34341517]
URI:	https://repository.monashhealth.org/monashhealthjspui/handle/1/47064
Type:	Article
Subjects:	breast cancer cancer risk cigarette smoking genetic risk score genetic susceptibility genome-wide association study Mendelian randomization analysis never smoker pleiotropy single nucleotide polymorphism cigarette smoke/to [Drug Toxicity]
Appears in Collections:	Articles

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