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Title: | Long term all-cause and cardiovascular disease mortality among women who undergo fertility treatment. | Authors: | Yiallourou S.R.;Magliano D.;Haregu T.N.;Carrington M.J.;Rolnik D.L. ;Rombauts L. ;Rodrigues A.;Ball J.;Bruinsma F.J.;Da Silva Costa F. | Institution: | (Yiallourou, Magliano, Haregu, Carrington) Baker Heart and Diabetes Institute, Melbourne, VIC, Australia (Yiallourou) The Turner Institute for Brain and Mental Health, Monash University, Melbourne, VIC, Australia (Magliano, Rolnik, Ball) Monash University, Melbourne, VIC, Australia (Haregu) Nossal Institute for Global Health, the University of Melbourne, Melbourne, VIC, Australia (Rolnik, Rombauts) Monash Health, Melbourne, VIC, Australia (Rombauts) Monash IVF, Melbourne, VIC, Australia (Rodrigues) The Parent-Infant Research Institute, Austin Health, Melbourne, VIC, Australia (Bruinsma) Cancer Council Victoria, Melbourne, VIC, Australia (Bruinsma) Centre for Epidemiology and Biostatistics, the University of Melbourne, VIC, Australia (Da Silva Costa) Gold Coast University Hospital, Gold Coast, QLD, Australia (Da Silva Costa) Griffith University, Gold Coast, QLD, Australia |
Issue Date: | 14-Mar-2023 | Copyright year: | 2022 | Publisher: | John Wiley and Sons Inc | Place of publication: | Australia | Publication information: | Medical Journal of Australia. 217(10) (pp 532-537), 2022. Date of Publication: 21 Nov 2022. | Journal: | Medical Journal of Australia | Abstract: | Objectives: To compare age-adjusted all-cause and CVD mortality, relative to the general female population, for women registered for fertility treatment who received it and those who did not. Design(s): Prospective cohort study; analysis of Monash IVF clinical registries data, 1975-2018, linked with National Death Index mortality data. Participant(s): All women who registered for fertility treatment at Monash IVF (Melbourne, Victoria), 1 January 1975 - 1 January 2014, followed until 31 December 2018. Main Outcome Measure(s): Standardised mortality ratios (SMRs) for all-cause and CVD mortality, for women who did or did not undergo fertility treatment; SMRs stratified by area-level socio-economic disadvantage (SEIFA Index of Relative Socioeconomic Disadvantage [IRSD]) and (for women who underwent treatment), by stimulated cycle number and mean oocytes/cycle categories. Result(s): Of 44 149 women registered for fertility treatment, 33 520 underwent treatment (66.4%), 10 629 did not. After adjustment for age, both all-cause (SMR, 0.58; 95% CI, 0.54-0.62) and CVD mortality (SMR, 0.41; 95% CI, 0.32-0.53) were lower than for the general female population. All-cause mortality was similar for women registered with Monash IVF who did (SMR, 0.55; 95% CI, 0.50-0.60) or did not undergo fertility treatment (SMR, 0.63; 95% CI, 0.56-0.70). The SMR was lowest for both treated and untreated women in the fifth IRSD quintile (least disadvantage), but the difference was statistically significant only for untreated women. CVD mortality was lower for registered women who underwent fertility treatment (SMR, 0.29; 95% CI, 0.19-0.43) than for those who did not (SMR, 0.58; 95% CI, 0.42-0.81). Conclusion(s): Fertility treatment does not increase long term all-cause or CVD mortality risk. Lower mortality among women registered for fertility treatment probably reflected their lower socio-economic disadvantage.Copyright © 2022 The Authors. Medical Journal of Australia published by John Wiley & Sons Australia, Ltd on behalf of AMPCo Pty Ltd. | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.5694/mja2.51734 | PubMed URL: | 36209740 [https://www.ncbi.nlm.nih.gov/pubmed/?term=36209740] | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/49485 | Type: | Article | Subjects: | cardiovascular disease cardiovascular mortality cardiovascular risk fertility hormone substitution hypertension infertility therapy metabolic syndrome X ovary follicle development ovary hyperstimulation pregnancy diabetes mellitus thrombosis clomifene |
Type of Clinical Study or Trial: | Observational study (cohort, case-control, cross sectional, or survey) |
Appears in Collections: | Articles |
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