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Title: | Food Allergen Immunotherapy in Preschool Children: Do We Have the Evidence? | Authors: | Loke P.;Vickery B.P.;Jones S.M.;Peters R.L.;Roberts G.;Koplin J.J. | Monash Health Department(s): | Paediatric - Allergy and Immunology | Institution: | (Loke, Peters, Koplin) Murdoch Children's Research Institute, Melbourne, Australia (Loke, Peters) Department of Paediatrics, University of Melbourne, Melbourne, Australia (Loke) Monash Children's Hospital, Melbourne, Australia (Loke) Department of Allergy and Immunology, Royal Children's Hospital, Melbourne, Australia (Vickery) Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Atlanta, Ga (Jones) Department of Pediatrics, Allergy, Immunology, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Ark (Roberts) Faculty of Medicine, University of Southampton, Southampton, United Kingdom (Roberts) NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom (Roberts) David Hide Asthma and Allergy Centre, St Mary's Hospital, Isle of Wight, United Kingdom (Koplin) Child Health Research Centre, University of Queensland, Brisbane, Australia |
Issue Date: | 8-Aug-2023 | Copyright year: | 2023 | Publisher: | American Academy of Allergy, Asthma and Immunology | Place of publication: | United States | Publication information: | Journal of Allergy and Clinical Immunology: In Practice. 11(4) (pp 1028-1035), 2023. Date of Publication: April 2023. | Journal: | Journal of Allergy and Clinical Immunology: in Practice | Abstract: | Standard care for the management of food allergies previously centered on allergen avoidance and the treatment of adverse reactions after allergen exposure. An increase in the development of immunotherapy treatments for food allergy has occurred over the past 2 decades, with many centers now offering immunotherapy. Previous studies mainly focused on school-age children in whom food allergies are likely to be persistent. However, there is increasing evidence that delivering immunotherapy for food allergy to preschool-age children may deliver higher rates of success, and that peanut allergen immunotherapy leads the way. Conversely, the natural resolution of food allergies occurs primarily in these younger age groups, resulting in challenges to selecting patients who will ultimately benefit from these treatments. Both immunotherapy and natural history studies reveal the inherent plasticity of the immune system in early life, which may be more amenable to intervention, but this raises a delicate yet unknown balance between the optimal timing of intervention versus waiting for natural resolution of the food allergy. Here we review the evidence for early food allergen immunotherapy in preschoolers, and present the pros and cons of this approach while acknowledging important research gaps in this age group.Copyright © 2023 American Academy of Allergy, Asthma & Immunology | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1016/j.jaip.2023.01.005 | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/49996 | Type: | Review | Subjects: | food allergy immune system immunotherapy plasticity quality of life taste bud food allergen food allergen immunotherapy |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
Appears in Collections: | Articles |
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