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https://repository.monashhealth.org/monashhealthjspui/handle/1/50630| Title: | Quantitative Gait and Balance Outcomes for Ataxia Trials: Consensus Recommendations by the Ataxia Global Initiative Working Group on Digital-Motor Biomarkers. | Authors: | Ilg W.;Milne S.;Schmitz-Hubsch T.;Alcock L.;Beichert L.;Bertini E.;Mohamed Ibrahim N.;Dawes H.;Gomez C.M.;Hanagasi H.;Kinnunen K.M.;Minnerop M.;Nemeth A.H.;Newman J.;Ng Y.S.;Rentz C.;Samanci B.;Shah V.V.;Summa S.;Vasco G.;McNames J.;Horak F.B. | Monash Health Department(s): | Physiotherapy Allied Health |
Institution: | (Ilg) Section Computational Sensomotorics, Hertie Institute for Clinical Brain Research, Otfried-Muller-Strase 25, Tubingen 72076, Germany (Ilg) Centre for Integrative Neuroscience (CIN), Tubingen, Germany (Milne) Bruce Lefroy Centre for Genetic Health Research, Murdoch Children's Research Institute, Parkville, VIC, Australia (Milne) Department of Paediatrics, Melbourne University, Melbourne, VIC, Australia (Milne) Physiotherapy Department, Monash Health, Clayton, VIC, Australia (Milne) School of Primary and Allied Health Care, Monash University, Frankston, VIC, Australia (Schmitz-Hubsch) Experimental and Clinical Research Center, a cooperation of Max-Delbrueck Center for Molecular Medicine and Charite, Universitatsmedizin Berlin, Berlin, Germany (Schmitz-Hubsch) Neuroscience Clinical Research Center, Charite - Universitatsmedizin Berlin, Berlin, Germany (Alcock) Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom (Alcock, Newman) NIHR Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne, United Kingdom (Beichert) Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany (Bertini) Research Unit of Neuromuscular and Neurodegenerative Disorders, Bambino Gesu' Children's Research Hospital, IRCCS, Rome, Italy (Mohamed Ibrahim) Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia (Dawes) NIHR Exeter BRC, College of Medicine and Health, University of Exeter, Exeter, United Kingdom (Gomez) Department of Neurology, The University of Chicago, Chicago, United States (Hanagasi, Samanci) Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey (Kinnunen) IXICO, London, United Kingdom (Minnerop, Rentz) Institute of Neuroscience and Medicine (INM-1)), Research Centre Juelich, Juelich, Germany (Minnerop) Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty & University Hospital Dusseldorf, Heinrich Heine University Dusseldorf, Dusseldorf, Germany (Minnerop) Department of Neurology, Center for Movement Disorders and Neuromodulation, Medical Faculty & University Hospital Dusseldorf, Heinrich Heine University Dusseldorf, Dusseldorf, Germany (Nemeth) Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom (Newman, Ng) Wellcome Centre for Mitochondrial Research, Newcastle University, Newcastle upon Tyne, United Kingdom (Shah, Horak) Department of Neurology, Oregon Health & Science University, Portland, OR, United States (Shah, McNames, Horak) APDM Precision Motion, Clario, Portland, OR, United States (Summa, Vasco) Movement Analysis and Robotics Laboratory (MARLab), Neurorehabilitation Unit, Neurological Science and Neurorehabilitation Area, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy (McNames) Department of Electrical and Computer Engineering, Portland State University, Portland, OR, United States |
Issue Date: | 17-Nov-2023 | Copyright year: | 2023 | Publisher: | Springer | Place of publication: | United States | Publication information: | Cerebellum. 23(4) (pp 1566-1592), 2024. Date of Publication: August 2024. | Journal: | Cerebellum | Abstract: | With disease-modifying drugs on the horizon for degenerative ataxias, ecologically valid, finely granulated, digital health measures are highly warranted to augment clinical and patient-reported outcome measures. Gait and balance disturbances most often present as the first signs of degenerative cerebellar ataxia and are the most reported disabling features in disease progression. Thus, digital gait and balance measures constitute promising and relevant performance outcomes for clinical trials. This narrative review with embedded consensus will describe evidence for the sensitivity of digital gait and balance measures for evaluating ataxia severity and progression, propose a consensus protocol for establishing gait and balance metrics in natural history studies and clinical trials, and discuss relevant issues for their use as performance outcomes.Copyright © 2023, The Author(s). | DOI: | http://monash.idm.oclc.org/login?url=https://dx.doi.org/10.1007/s12311-023-01625-2 | PubMed URL: | 37955812 [https://www.ncbi.nlm.nih.gov/pubmed/?term=37955812] | URI: | https://repository.monashhealth.org/monashhealthjspui/handle/1/50630 | Type: | Review | Subjects: | ataxia cerebellar ataxia gait |
Type of Clinical Study or Trial: | Review article (e.g. literature review, narrative review) |
| Appears in Collections: | Articles |
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